| Entry |
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| Name |
hyaluronate lyase;
hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)];
glucuronoglycosaminoglycan lyase;
spreading factor;
mucinase
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
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| Sysname |
hyaluronate lyase
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| Reaction(IUBMB) |
Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine [RN: R02465 R06242]
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| Reaction(KEGG) |
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| Comment |
Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
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| Orthology |
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| Genes |
CTU: | | VVY: | | VFI: | | VFM: | | HFE: | | HBI: | | BSE: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAX: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAB: | | SUY: | | SAUB: | | SAUM: | | PMS: | | PMQ: | | PMW: | | SPY: | | SPZ: | | SPYM: | | SPH: | | SPI: | | SPJ: | | SPK: | | SPA: | | SPB: | | STG: | | SOZ: | | STZ: | | STX: | | SPYA: | | SPN: | | SPD: | | SPR: | | SPX: | | SNE: | | SPV: | | SNM: | | SJJ: | | SPP: | | SNT: | | SNC: | | SNB: | | SNP: | | SNI: | | SNV: | | SND: | | SNU: | | SPNG: | | SAG: | | SAN: | | SAK: | | SGC: | | SAGS: | | SST: | | SSQ: | | SRP: | | SUP: | | SEQ: | | SEZ: | | SDS: | | SDG: | | SDA: | | SDC: | | STK: | | SIE: | | LCZ: | | LCS: | | LCE: | | LCW: | | LRL: | | LRA: | | EFL: | | EFS: | | ENE: | | CBN: | | CSH: | | ERH: | | MCD: | | MFR: | | MFM: | | MFP: | | SCO: | | SGR: | | SCB: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | STRP: | | MTS: | | ART: | | AAU: | | ARR: | | BCV: | | PAC: | | PAK: | | PAV: | | PAX: | | PAZ: | | PAW: | | PAD: | | PCN: | | PACC: | | KFL: | | SRO: | | AMD: | | AMN: | | AMM: | | CAI: | | SNA: | | TBE: | | SMF: | |
» show all
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| Reference |
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| Authors |
LINKER A, HOFFMAN P, MEYER K, SAMPSON P, KORN ED. |
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| Title |
The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to alpha-keto acid by bacterial enzymes. |
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| Journal |
J. Biol. Chem. 235 (1960) 3061-5. |
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| Reference |
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| Authors |
MEYER K, RAPPORT MM. |
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| Title |
Hyaluronidases. |
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| Journal |
Adv. Enzymol. Relat. Subj. Biochem. 13 (1952) 199-236. |
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| Reference |
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| Authors |
Moran F, Nasuno S, Starr MP. |
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| Title |
Extracellular and intracellular polygllacturonic acid trans-eliminases of Erwinia carotovora. |
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| Journal |
Arch. Biochem. Biophys. 123 (1968) 298-306. |
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| Organism |
Erwinia carotovora [GN: eca] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37259-53-3 |
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