KEGG   ENZYME: 4.2.2.2Help
Entry
EC 4.2.2.2                  Enzyme                                 
Name
pectate lyase;
polygalacturonic transeliminase;
pectic acid transeliminase;
polygalacturonate lyase;
endopectin methyltranseliminase;
pectate transeliminase;
endogalacturonate transeliminase;
pectic acid lyase;
pectic lyase;
alpha-1,4-D-endopolygalacturonic acid lyase;
PGA lyase;
PPase-N;
endo-alpha-1,4-polygalacturonic acid lyase;
polygalacturonic acid lyase;
pectin trans-eliminase;
Polygalacturonic acid trans-eliminase
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
(1->4)-alpha-D-galacturonan lyase
Reaction(IUBMB)
Eliminative cleavage of (1->4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends [RN:R08694]
Reaction(KEGG)
Comment
Favours pectate, the anion, over pectin, the methyl ester (which is the preferred substrate of EC 4.2.2.10, pectin lyase).
Pathway
Pentose and glucuronate interconversions
Orthology
K01728  
pectate lyase
Genes
ATH: 
ALY: 
GMX: 
MTR: 
CSV: 
RCU: 
POP: 
VVI: 
OSA: 
DOSA: 
Os01t0546800-01(Os01g0546800) Os02t0214400-01(Os02g0214400) Os06t0144200-01(Os06g0144200) Os06t0583900-01(Os06g0583900) Os08t0286100-00(Os08g0286100) Os10t0457200-00(Os10g0457200)
BDI: 
100824254 100829073 100834927 100836039 100841005 100842200 100843977 100846807
SBI: 
SORBI_01g020180(SORBIDRAFT_01g020180) SORBI_03g036930(SORBIDRAFT_03g036930) SORBI_03g039150(SORBIDRAFT_03g039150) SORBI_04g007450(SORBIDRAFT_04g007450) SORBI_06g001410(SORBIDRAFT_06g001410) SORBI_08g004905(SORBIDRAFT_08g004905) SORBI_10g003090(SORBIDRAFT_10g003090) SORBI_10g022830(SORBIDRAFT_10g022830)
ZMA: 
100273705 100281162 100281581 100283618(pco073276b) 100284356 100502180
SMO: 
SELMODRAFT_108753 SELMODRAFT_407495 SELMODRAFT_421674 SELMODRAFT_81909 SELMODRAFT_85792 SELMODRAFT_93746
PPP: 
PHYPADRAFT_134426 PHYPADRAFT_140990 PHYPADRAFT_183643 PHYPADRAFT_207105 PHYPADRAFT_212895 PHYPADRAFT_62027
PAN: 
PODANSg1157 PODANSg1215
MTM: 
MYCTH_52463 MYCTH_71204 MYCTH_97932
MGR: 
MGG_04348
FGR: 
FG03908.1 FG09291.1
NHE: 
NECHADRAFT_34871 NECHADRAFT_58553
VAL: 
VDBG_05825 VDBG_09483
SSL: 
SS1G_00238
BFU: 
BC1G_00912
ANI: 
AN0741.2 AN7646.2
NFI: 
NFIA_033040
AFM: 
AFUA_1G01120 AFUA_2G00760 AFUA_7G06400 AFUA_8G05910
AOR: 
AOR_1_1156054(AO090011000673) AOR_1_590114(AO090701000321)
ANG: 
ANI_1_102174(An10g00870)
AFV: 
AFLA_044970 AFLA_057770
PCS: 
Pc22g24890
PNO: 
SNOG_13910
ZTR: 
MYCGRDRAFT_85457(MgPel3)
TML: 
GSTUM_00008534001
MPR: 
MPER_05125 MPER_07146 MPER_09765
CCI: 
CC1G_11098
SCM: 
SCHCODRAFT_231907 SCHCODRAFT_47036
YPE: 
YPO3994(pelY)
YPK: 
y3834
YPA: 
YPA_3822
YPN: 
YPN_3644
YPM: 
YP_3357(pelY)
YPG: 
YpAngola_A4065
YPZ: 
YPZ3_2172(pelY)
YPT: 
A1122_05850
YPD: 
YPD4_3514(pelY)
YPX: 
YPD8_3520(pelY)
YPH: 
YPC_4503(pelY)
YPS: 
YPTB3834(pelY)
YPI: 
YpsIP31758_4066
YPY: 
YPK_0096
YPB: 
YPTS_4050
YEN: 
YE4069(pelY)
YEP: 
YE105_C3787
YEY: 
Y11_31271
ECA: 
ECA2135 ECA3112 ECA4067(pelA) ECA4068(pelB) ECA4069(pelC)
PCT: 
PC1_2170 PC1_2863 PC1_3858 PC1_3859 PC1_3860
PCC: 
PCC21_022490 PCC21_029360 PCC21_038500 PCC21_038510 PCC21_038520
PWA: 
Pecwa_2511 Pecwa_4035 Pecwa_4036 Pecwa_4037
PEC: 
W5S_2484 W5S_4192 W5S_4193 W5S_4194
ENT: 
Ent638_0482
KOX: 
KOX_16835
DDA: 
Dd703_0352 Dd703_0353 Dd703_2763 Dd703_2764
DDC: 
Dd586_3083 Dd586_3084 Dd586_3085 Dd586_3788 Dd586_3789
DDD: 
Dda3937_03370(pelA) Dda3937_03371(pelE) Dda3937_03372(pelD) Dda3937_04192(pelC) Dda3937_04193(pelB)
DZE: 
Dd1591_0270 Dd1591_0271 Dd1591_1089 Dd1591_1090 Dd1591_1091
XCC: 
XCC0644(pel) XCC0645(pel) XCC2815(pelB)
XCB: 
XC_1298 XC_3590 XC_3591
XCA: 
xccb100_1345(pel1) xccb100_3710(pel2) xccb100_3711(pel3)
XCV: 
XCV2278 XCV2569 XCV3132(pel1) XCV3687(pel2)
XCP: 
XCR_0794 XCR_0795 XCR_3187
XAC: 
XAC2373(pel) XAC2986(pelB) XAC3562(pel)
XAO: 
XAC29_12025 XAC29_15180 XAC29_18135
XOO: 
XOO0821(pel) XOO2265
XOM: 
XOO_0747
XOP: 
PXO_02650
XOR: 
XOC_3823(pel)
XCI: 
XCAW_02038(pel) XCAW_03264(pelB) XCAW_04262(pel)
PFS: 
PFLU3229
CJA: 
CJA_0533(pel1B) CJA_1277(pelC)
SDE: 
Sde_3448
HCH: 
HCH_03164
MMW: 
Mmwyl1_0132 Mmwyl1_2362
MPC: 
Mar181_0103 Mar181_1624
SAGA: 
M5M_10280
BPH: 
Bphy_7394
BGE: 
BC1002_7028
BPX: 
BUPH_04694
BPT: 
Bpet0241
AXY: 
AXYL_00243
AAV: 
Aave_3434
AAA: 
Acav_3299
CCO: 
CCC13826_0280 CCC13826_0281
SME: 
SM_b21239
SMD: 
Smed_6139
BSU: 
BSU07560(pel)
BSR: 
I33_0847
BSL: 
A7A1_0657
BSH: 
BSU6051_07560(pel)
BSY: 
I653_03790
BSS: 
BSUW23_03840(pel)
BST: 
GYO_1020
BSO: 
BSNT_01271(pel)
BSN: 
BSn5_15680
BSQ: 
B657_07560(pel)
BSUB: 
BEST7613_0748(pel)
BSX: 
C663_0779(pel)
BLI: 
BL03760(pel)
BLD: 
BLi01404(pel)
BAO: 
BAMF_0717(pel)
BAY: 
RBAM_007720(pel)
BAQ: 
BACAU_0741(pel)
BYA: 
BANAU_0687(pel)
BAMP: 
B938_03665
BAML: 
BAM5036_0685(pel)
BAZ: 
BAMTA208_03390(pel)
BQL: 
LL3_00769(pel)
BXH: 
BAXH7_00714(pel)
BQY: 
MUS_0758(pel)
BAMI: 
KSO_015960
BAE: 
BATR1942_01360
BHA: 
BH0698
BCL: 
ABC0063(pelB) ABC1141
BPU: 
BPUM_3515(pelB)
BJS: 
MY9_0846
GYM: 
GYMC10_3035 GYMC10_3050
PPY: 
PPE_03469
PPM: 
PPSC2_c3976
PMS: 
KNP414_03678
PMQ: 
PM3016_1073
PMW: 
B2K_05465
PTA: 
HPL003_27060
MPS: 
MPTP_1720
LCI: 
LCK_00931(pel)
LKI: 
LKI_06180
LEC: 
LGMK_05955
CCE: 
Ccel_2243
CCB: 
Clocel_1172
BPB: 
bpr_I2372(pel1A)
SCO: 
SCO1880(SCI39.27c)
SMA: 
SAV_6375
SGR: 
SGR_216
SCB: 
SCAB_70551
SSX: 
SACTE_1312
SVL: 
Strvi_5407 Strvi_7573
SFA: 
Sfla_4931
SBH: 
SBI_02172 SBI_03542 SBI_07422 SBI_08109 SBI_08116
SVE: 
SVEN_6618
SDV: 
BN159_6622(pel)
STRP: 
F750_1751
CMC: 
CMN_02654
AAU: 
AAur_0236
ACH: 
Achl_0495 Achl_1178 Achl_3821
APN: 
Asphe3_38540
ARR: 
ARUE_c02330
IVA: 
Isova_0504
TFU: 
Tfu_0153
NDA: 
Ndas_5013
TCU: 
Tcur_2436
SRO: 
Sros_1493
TBI: 
Tbis_1087
AMD: 
AMED_4436(pel)
AMN: 
RAM_22590
AMM: 
AMES_4382(pel)
AMI: 
Amir_1843
MAU: 
Micau_3552
MIL: 
ML5_4844
VMA: 
VAB18032_24045
AMS: 
AMIS_43970 AMIS_43990 AMIS_55080 AMIS_58590
ASE: 
ACPL_5020 ACPL_5377(pel)
TBE: 
Trebr_2555
SCD: 
Spica_0054
NKO: 
Niako_4603
FJO: 
Fjoh_2566
FBA: 
FIC_01877
FSU: 
Fisuc_0174
FSC: 
FSU_0577
RBA: 
RB3417 RB5312(pel) RB5316
TMA: 
TM0433
TLE: 
Tlet_1137
TRQ: 
TRQ2_0511
DTH: 
DICTH_0315
DTU: 
Dtur_0431
 » show all
Taxonomy
Reference
1  [PMID:13860094]
  Authors
ALBERSHEIM P, KILLIAS U.
  Title
Studies relating to the purification and properties of pectin transeliminase.
  Journal
Arch. Biochem. Biophys. 97 (1962) 107-15.
  Organism
Pisum sativum
Reference
2  [PMID:14235514]
  Authors
EDSTROM RD, PHAFF HJ.
  Title
PURIFICATION AND CERTAIN PROPERTIES OF PECTIN TRANS-ELIMINASE FROM ASPERGILLUS FONSECAEUS.
  Journal
J. Biol. Chem. 239 (1964) 2403-8.
  Organism
Aspergillus fonsecaeus
Reference
3  [PMID:14235515]
  Authors
EDSTROM RD, PHAFF HJ.
  Title
ELIMINATIVE CLEAVAGE OF PECTIN AND OF OLIGOGALACTURONIDE METHYL ESTERS BY PECTIN TRANS-ELIMINASE.
  Journal
J. Biol. Chem. 239 (1964) 2409-15.
  Organism
Aspergillus fonsecaeus
Reference
4  [PMID:13727438]
  Authors
NAGEL CW, VAUGHN RH.
  Title
The degradation of oligogalacturonides by the polygalacturonase of Bacillus polymyxa.
  Journal
Arch. Biochem. Biophys. 94 (1961) 328-32.
  Organism
Bacillus polymyxa
Reference
5  [PMID:6035509]
  Authors
Nasuno S, Starr MP.
  Title
Polygalacturonic acid trans-eliminase of Xanthomonas campestris.
  Journal
Biochem. J. 104 (1967) 178-85.
  Organism
Xanthomonas campestris
Reference
6  [PMID:9195887]
  Authors
Mayans O, Scott M, Connerton I, Gravesen T, Benen J, Visser J, Pickersgill R, Jenkins J.
  Title
Two crystal structures of pectin lyase A from Aspergillus reveal a pH driven conformational change and striking divergence in the substrate-binding clefts of pectin and pectate lyases.
  Journal
Structure. 5 (1997) 677-89.
  Organism
Aspergillus niger [GN:ang]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9015-75-2
DBGET integrated database retrieval system