KEGG   ENZYME: 4.2.3.103Help
Entry
EC 4.2.3.103                Enzyme                                 

Name
ent-isokaurene synthase;
OsKSL5i;
OsKSL6
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-isokaurene-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-isokaurene + diphosphate [RN:R09903]
Reaction(KEGG)
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-isokaurene [CPD:C20145];
diphosphate [CPD:C00013]
Comment
Two enzymes of the rice sub-species Oryza sativa ssp. indica, OsKSL5 and OsKSL6, produce ent-isokaurene. A variant of OsKSL5 from the sub-species Oryza sativa ssp. japonica produces ent-pimara-8(14),15-diene instead [cf. EC 4.2.3.30, ent-pimara-8(14),15-diene synthase].
History
EC 4.2.3.103 created 2012
Pathway
Diterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K16082  
ent-isokaurene synthase
Genes
OSA: 
DOSA: 
Os02t0571800-00(Os02g0571800)
Taxonomy
Reference
1  [PMID:17141283]
  Authors
Xu M, Wilderman PR, Morrone D, Xu J, Roy A, Margis-Pinheiro M, Upadhyaya NM, Coates RM, Peters RJ
  Title
Functional characterization of the rice kaurene synthase-like gene family.
  Journal
Phytochemistry. 68 (2007) 312-26.
  Organism
Oryza sativa, Oryza sativa subsp. indica
  Sequence
[osa:4329729] [up:A4KAG7 A4KAG8]
Reference
2  [PMID:17456599]
  Authors
Xu M, Wilderman PR, Peters RJ
  Title
Following evolution's lead to a single residue switch for diterpene synthase product outcome.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 7397-401.
  Organism
Oryza sativa, Oryza sativa subsp. indica
  Sequence
[osa:4329729] [up:A4KAG7]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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