KEGG   ENZYME: 4.2.3.113Help
Entry
EC 4.2.3.113                Enzyme                                 

Name
terpinolene synthase;
ag9;
PmeTPS2;
LaLIMS_RR
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase (cyclizing, terpinolene-forming)
Reaction(IUBMB)
geranyl diphosphate = terpinolene + diphosphate [RN:R02010]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341]
Product
terpinolene [CPD:C06075];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Mn2+ is less effective and product ratio changes. Forms traces of other monoterpenoids.
History
EC 4.2.3.113 created 2012
Reference
1  [PMID:2768265]
  Authors
Croteau R, Satterwhite DM
  Title
Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage.
  Journal
J. Biol. Chem. 264 (1989) 15309-15.
  Organism
Salvia officinalis
Reference
2  [PMID:10441373]
  Authors
Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R
  Title
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).
  Journal
Arch. Biochem. Biophys. 368 (1999) 232-43.
  Organism
Abies grandis
  Sequence
[up:Q9M7D0]
Reference
3  [PMID:12602896]
  Authors
Faldt J, Martin D, Miller B, Rawat S, Bohlmann J
  Title
Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced  terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase.
  Journal
Plant. Mol. Biol. 51 (2003) 119-33.
  Organism
Picea abies
Reference
4  [PMID:15921711]
  Authors
Huber DP, Philippe RN, Godard KA, Sturrock RN, Bohlmann J
  Title
Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii.
  Journal
Phytochemistry. 66 (2005) 1427-39.
  Organism
Pseudotsuga menziesii
Reference
5  [PMID:17662687]
  Authors
Landmann C, Fink B, Festner M, Dregus M, Engel KH, Schwab W
  Title
Cloning and functional characterization of three terpene synthases from lavender  (Lavandula angustifolia).
  Journal
Arch. Biochem. Biophys. 465 (2007) 417-29.
  Organism
Lavandula angustifolia
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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