KEGG   ENZYME: 4.2.3.118Help
Entry
EC 4.2.3.118                Enzyme                                 

Name
2-methylisoborneol synthase;
sco7700;
2-MIB cyclase;
MIB synthase;
MIBS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming)
Reaction(IUBMB)
(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate [RN:R09973]
Reaction(KEGG)
Substrate
(E)-2-methylgeranyl diphosphate [CPD:C20235];
H2O [CPD:C00001]
Product
2-methylisoborneol [CPD:C20243];
diphosphate [CPD:C00013]
Comment
The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.
History
EC 4.2.3.118 created 2012
Orthology
K16218  
2-methylisoborneol synthase
Genes
NBR: 
SCO: 
SCO7700(SC1A4.08)
SGR: 
SCB: 
SVL: 
SFA: 
SBH: 
SVE: 
SDV: 
STRP: 
SCI: 
SRC: 
KSK: 
NDA: 
NAL: 
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AOI: 
SESP: 
ASE: 
CAI: 
SNA: 
 » show all
Taxonomy
Reference
1  [PMID:18563898]
  Authors
Wang CM, Cane DE
  Title
Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
  Journal
J. Am. Chem. Soc. 130 (2008) 8908-9.
  Sequence
[sco:SCO7700]
Reference
2  [PMID:18492804]
  Authors
Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H
  Title
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 7422-7.
  Sequence
Reference
3  [PMID:21174459]
  Authors
Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT
  Title
Biosynthesis of 2-methylisoborneol in cyanobacteria.
  Journal
Environ. Sci. Technol. 45 (2011) 992-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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