KEGG   ENZYME: 4.2.3.13Help
Entry
EC 4.2.3.13                 Enzyme                                 

Name
(+)-delta-cadinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate [RN:R02311]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-delta-cadinene [CPD:C06394];
diphosphate [CPD:C00013]
Comment
The sesquiterpenoid (+)-delta-cadinene is an intermediate in phytoalexin biosynthesis. Mg2+ is required for activity.
History
EC 4.2.3.13 created 1999 as EC 4.6.1.11, transferred 2000 to EC 4.2.3.13, modified 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K14183  
(+)-delta-cadinene synthase
Reference
1  [PMID:8554317]
  Authors
Chen XY, Chen Y, Heinstein P, Davisson VJ.
  Title
Cloning, expression, and characterization of (+)-delta-cadinene synthase: a catalyst for cotton phytoalexin biosynthesis.
  Journal
Arch. Biochem. Biophys. 324 (1995) 255-66.
  Organism
Gossypium arboreum
  Sequence
Reference
2  [PMID:8728715]
  Authors
Davis EM, Tsuji J, Davis GD, Pierce ML, Essenberg M.
  Title
Purification of (+)-delta-cadinene synthase, a sesquiterpene cyclase from bacteria-inoculated cotton foliar tissue.
  Journal
Phytochemistry. 41 (1996) 1047-55.
  Organism
Gossypium hirsutum
  Sequence
[up:P93665]
Reference
3
  Authors
Davis, G.D., Essenberg, M.
  Title
(+)-delta-Cadinene is a product of sesquiterpene cyclase activity in cotton.
  Journal
Phytochemistry 39 (1995) 553-567.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
166800-09-5

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