KEGG   ENZYME: 4.2.3.134Help
Entry
EC 4.2.3.134                Enzyme                                 

Name
5-phosphonooxy-L-lysine phospho-lyase;
5-phosphohydroxy-L-lysine ammoniophospholyase;
AGXT2L2 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
Reaction(IUBMB)
(5R)-5-phosphonooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate [RN:R10270]
Reaction(KEGG)
Substrate
(5R)-5-phosphonooxy-L-lysine [CPD:C03366];
H2O [CPD:C00001]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NH3 [CPD:C00014];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).
History
EC 4.2.3.134 created 2012
Pathway
Lysine degradation
Metabolic pathways
Orthology
K18202  
5-phosphonooxy-L-lysine phospho-lyase
Genes
HSA: 
85007(PHYKPL)
PTR: 
462320(AGXT2L2)
PPS: 
100991193(AGXT2L2)
GGO: 
101136630(AGXT2L2)
PON: 
100442768(AGXT2L2)
MCC: 
702302(AGXT2L2)
MCF: 
102115019(PHYKPL)
MMU: 
72947(Phykpl)
RNO: 
CGE: 
100767825(Phykpl)
HGL: 
101713270(Phykpl)
TUP: 
102467962(PHYKPL)
CFA: 
481448(PHYKPL)
AML: 
FCA: 
101098679(PHYKPL)
PTG: 
102972570(PHYKPL)
BTA: 
537241(AGXT2L2)
BOM: 
102276016(PHYKPL)
PHD: 
102327522(PHYKPL)
CHX: 
102191693(PHYKPL)
SSC: 
100521952(PHYKPL)
CFR: 
102522088(PHYKPL)
BACU: 
103000047(PHYKPL)
LVE: 
103086842(PHYKPL)
ECB: 
100068397(PHYKPL)
MYB: 
102249621(PHYKPL)
MYD: 
102752367(PHYKPL)
PALE: 
102886040(PHYKPL)
SHR: 
100916686(AGXT2L2)
OAA: 
100088790(PHYKPL)
GGA: 
416374(AGXT2L2)
MGP: 
100538852(AGXT2L2)
TGU: 
100223371(AGXT2L2)
FAB: 
101818003(PHYKPL)
PHI: 
102111638(PHYKPL)
APLA: 
101797808(PHYKPL)
FPG: 
101922212(PHYKPL)
FCH: 
102056780(PHYKPL)
CLV: 
102087033(PHYKPL)
ASN: 
102378538(PHYKPL)
AMJ: 
102563632(PHYKPL)
PSS: 
102450136(PHYKPL)
CMY: 
102946291(PHYKPL)
ACS: 
100558326(agxt2l2)
PBI: 
103068075(PHYKPL)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347768(PHYKPL)
CMK: 
103183728(phykpl)
 » show all
Taxonomy
Reference
1  [PMID:4412716]
  Authors
Tsai CH, Henderson LM
  Title
Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase.
  Journal
J. Biol. Chem. 249 (1974) 5784-9.
Reference
2  [PMID:22241472]
  Authors
Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E
  Title
Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.
  Journal
J. Biol. Chem. 287 (2012) 7246-55.
  Organism
Homo sapiens
  Sequence
[hsa:85007]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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