KEGG   ENZYME: 4.2.3.135Help
Entry
EC 4.2.3.135                Enzyme                                 

Name
Delta6-protoilludene synthase;
6-protoilludene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Delta6-protoilludene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = Delta6-protoilludene + diphosphate [RN:R10271]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
Delta6-protoilludene [CPD:C20476];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Armillaria gallica. Delta6-Protoilludene is the first step in the biosynthesis of the melleolides.
History
EC 4.2.3.135 created 2012
Reference
1  [PMID:21148562]
  Authors
Engels B, Heinig U, Grothe T, Stadler M, Jennewein S
  Title
Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides.
  Journal
J. Biol. Chem. 286 (2011) 6871-8.
  Organism
Armillaria gallica
  Sequence
[up:P0DL13]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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