KEGG   ENZYME: 4.2.3.138Help
Entry
EC 4.2.3.138                Enzyme                                 

Name
(+)-epi-alpha-bisabolol synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-epi-alpha-bisabolol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate [RN:R10274]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(+)-epi-alpha-bisabolol [CPD:C20479];
diphosphate [CPD:C00013]
Comment
Isolated from the plant Phyla dulcis (Aztec sweet herb). (+)-epi-alpha-Bisabolol is the precursor of the sweetener hernandulcin.
Reference
1  [PMID:22867794]
  Authors
Attia M, Kim SU, Ro DK
  Title
Molecular cloning and characterization of (+)-epi-alpha-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis.
  Journal
Arch. Biochem. Biophys. 527 (2012) 37-44.
  Organism
Phyla dulcis
  Sequence
[up:J7LH11]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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