KEGG   ENZYME: 4.2.3.15Help
Entry
EC 4.2.3.15                 Enzyme                                 

Name
myrcene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase (myrcene-forming)
Reaction(IUBMB)
geranyl diphosphate = myrcene + diphosphate [RN:R02009]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341]
Product
myrcene [CPD:C06074];
diphosphate [CPD:C00013]
Comment
A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.
History
EC 4.2.3.15 created 2000 as EC 4.1.99.9, transferred 2000 to EC 4.2.3.15
Pathway
Monoterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K12467  
myrcene/ocimene synthase
Genes
ATH: 
ALY: 
CRB: 
Taxonomy
Reference
1  [PMID:9268308]
  Authors
Bohlmann J, Steele CL, Croteau R.
  Title
Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.
  Journal
J. Biol. Chem. 272 (1997) 21784-92.
  Sequence
[up:O24474]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
197462-59-2

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