| Entry |
|
|---|
| Name |
abietadiene synthase;
copalyl-diphosphate diphosphate-lyase (cyclizing) |
|---|
| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
 |
|---|
| Sysname |
(+)-copalyl-diphosphate diphosphate-lyase [cyclizing;
(-)-abietadiene-forming] |
|---|
| Reaction(IUBMB) |
(+)-copalyl diphosphate = (-)-abietadiene + diphosphate [RN:R06301] |
|---|
| Reaction(KEGG) |
R06301;
(other) R06299 R06300 R06302 R06303 R06304
 |
|---|
| Substrate |
(+)-copalyl diphosphate [CPD:C11901] |
|---|
| Product |
(-)-abietadiene [CPD:C11878];
diphosphate [CPD:C00013] |
|---|
| Comment |
Part of a bifunctional enzyme involved in the biosynthesis of
abietadiene. See also EC 5.5.1.12 (copalyl diphosphate synthase).
Requires Mg2+ |
|---|
| Pathway |
PATH: ec00904 Diterpenoid biosynthesis
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K12927 abietadiene synthase/copalyl diphosphate synthase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11112547]
Peters RJ, Flory JE, Jetter R, Ravn MM, Lee HJ, Coates RM, Croteau
RB.
Abietadiene synthase from grand fir (Abies grandis):
characterization and mechanism of action of the
"pseudomature" recombinant enzyme.
Biochemistry. 39 (2000) 15592-602.
Abies grandis |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:11552804]
Peters RJ, Ravn MM, Coates RM, Croteau RB.
Bifunctional abietadiene synthase: free diffusive transfer of the
(+)-copalyl diphosphate intermediate between two distinct active
sites.
J. Am. Chem. Soc. 123 (2001) 8974-8.
Abies grandis |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:11805316]
Peters RJ, Croteau RB.
Abietadiene synthase catalysis: mutational analysis of a prenyl
diphosphate ionization-initiated cyclization and rearrangement.
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 580-4.
Abies grandis |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:11827528]
Peters RJ, Croteau RB.
Abietadiene synthase catalysis: conserved residues involved in
protonation-initiated cyclization of geranylgeranyl diphosphate to
(+)-copalyl diphosphate.
Biochemistry. 41 (2002) 1836-42.
Abies grandis |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:12059223]
Ravn MM, Peters RJ, Coates RM, Croteau R.
Mechanism of abietadiene synthase catalysis: stereochemistry and
stabilization of the cryptic pimarenyl carbocation intermediates.
J. Am. Chem. Soc. 124 (2002) 6998-7006.
Abies grandis |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.2.3.18
IUBMB Enzyme Nomenclature: 4.2.3.18
ExPASy - ENZYME nomenclature database: 4.2.3.18
BRENDA, the Enzyme Database: 4.2.3.18
CAS: 157972-08-2 |
|---|
