KEGG   ENZYME: 4.2.3.38Help
Entry
EC 4.2.3.38                 Enzyme                                 

Name
alpha-bisabolene synthase;
bisabolene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate [RN:R08370]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(E)-alpha-bisabolene [CPD:C19749];
diphosphate [CPD:C00013]
Comment
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding.
History
EC 4.2.3.38 created 2009
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K14177  
alpha-bisabolene synthase
Reference
1  [PMID:9618485]
  Authors
Bohlmann J, Crock J, Jetter R, Croteau R
  Title
Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-alpha-bisabolene synthase from grand fir (Abies grandis).
  Journal
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 6756-61.
  Organism
Abies grandis
  Sequence
[up:O81086]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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