KEGG   ENZYME: 4.2.3.48Help
Entry
EC 4.2.3.48                 Enzyme                                 

Name
(3S,6E)-nerolidol synthase;
(E)-nerolidol synthase;
nerolidol synthase;
(3S)-(E)-nerolidol synthase;
FaNES1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate [RN:R08374]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(3S,6E)-nerolidol [CPD:C09704];
diphosphate [CPD:C00013]
Comment
The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.
History
EC 4.2.3.48 created 2010
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14175  
(3S,6E)-nerolidol synthase
Reference
1  [PMID:15522848]
  Authors
Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ
  Title
Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species.
  Journal
Plant. Cell. 16 (2004) 3110-31.
  Organism
Fragaria ananassa
  Sequence
Reference
2  [PMID:10482672]
  Authors
Bouwmeester HJ, Verstappen FW, Posthumus MA, Dicke M
  Title
Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.
  Journal
Plant. Physiol. 121 (1999) 173-80.
Reference
3  [PMID:10805454]
  Authors
Degenhardt J, Gershenzon J
  Title
Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis.
  Journal
Planta. 210 (2000) 815-22.
Reference
4  [PMID:17924138]
  Authors
Arimura G, Garms S, Maffei M, Bossi S, Schulze B, Leitner M, Mithofer A, Boland W
  Title
Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of  jasmonate, ethylene and calcium signaling.
  Journal
Planta. 227 (2008) 453-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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