KEGG   ENZYME: 4.2.3.56Help
Entry
EC 4.2.3.56                 Enzyme                                 

Name
gamma-humulene synthase;
humulene cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (gamma-humulene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = gamma-humulene + diphosphate [RN:R08540]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
gamma-humulene [CPD:C16829];
diphosphate [CPD:C00013]
History
EC 4.2.3.56 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14186  
gamma-humulene synthase
Reference
1  [PMID:9442047]
  Authors
Steele CL, Crock J, Bohlmann J, Croteau R.
  Title
Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase.
  Journal
J. Biol. Chem. 273 (1998) 2078-89.
  Sequence
[up:O64405]
Reference
2  [PMID:12051690]
  Authors
Little DB, Croteau RB
  Title
Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.
  Journal
Arch. Biochem. Biophys. 402 (2002) 120-35.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
110639-19-5

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