KEGG   ENZYME: 4.2.3.67Help
Entry
EC 4.2.3.67                 Enzyme                                 

Name
cis-muuroladiene synthase;
MxpSS1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cis-muuroladiene-forming)
Reaction(IUBMB)
(1) (2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate [RN:R09626];
(2) (2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate [RN:R09627]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
cis-muurola-3,5-diene [CPD:C19753];
diphosphate [CPD:C00013];
cis-muurola-4(14),5-diene [CPD:C19754]
Comment
The recombinant enzyme from black peppermint (Mentha x piperita) gave a mixture of cis-muurola-3,5-diene (45%) and cis-muurola-4(14),5-diene (43%).
History
EC 4.2.3.67 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15809  
cis-muuroladiene synthase
Reference
1  [PMID:16083926]
  Authors
Prosser IM, Adams RJ, Beale MH, Hawkins ND, Phillips AL, Pickett JA, Field LM
  Title
Cloning and functional characterisation of a cis-muuroladiene synthase from black peppermint (Menthaxpiperita) and direct evidence for a chemotype unable to synthesise farnesene.
  Journal
Phytochemistry. 67 (2006) 1564-71.
  Sequence
[up:Q5W283]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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