KEGG   ENZYME: 4.2.3.76Help
Entry
EC 4.2.3.76                 Enzyme                                 

Name
(+)-delta-selinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-delta-selinene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-delta-selinene + diphosphate [RN:R09616]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-delta-selinene [CPD:C19742];
diphosphate [CPD:C00013]
Comment
Initial cyclization gives germacrene C in an enzyme bound form which is not released to the medium.
History
EC 4.2.3.76 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15806  
(+)-delta-selinene synthase
Reference
1  [PMID:9442047]
  Authors
Steele CL, Crock J, Bohlmann J, Croteau R.
  Title
Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase.
  Journal
J. Biol. Chem. 273 (1998) 2078-89.
  Sequence
[up:O64404]
Reference
2  [PMID:12051690]
  Authors
Little DB, Croteau RB
  Title
Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.
  Journal
Arch. Biochem. Biophys. 402 (2002) 120-35.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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