KEGG   ENZYME: 4.2.3.89Help
Entry
EC 4.2.3.89                 Enzyme                                 

Name
(+)-beta-caryophyllene synthase;
GcoA
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-beta-caryophyllene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-beta-caryophyllene + diphosphate [RN:R09889]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-beta-caryophyllene [CPD:C19973];
diphosphate [CPD:C00013]
Comment
A multifunctional enzyme which also converts the (+)-beta-caryophyllene to (+)-caryolan-1-ol (see EC 4.2.1.138, (+)-caryolan-1-ol synthase). cf. EC 4.2.3.57 (-)-beta-caryophyllene synthase.
History
EC 4.2.3.89 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18111  
(+)-beta-caryophyllene/(+)-caryolan-1-ol synthase
Genes
SGR: 
SSX: 
SFI: 
Taxonomy
Reference
1  [PMID:21693706]
  Authors
Nakano C, Horinouchi S, Ohnishi Y
  Title
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.
  Journal
J. Biol. Chem. 286 (2011) 27980-7.
  Organism
Streptomyces griseus
  Sequence
[sgr:SGR_2079]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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