KEGG   ENZYME: 4.2.3.91Help
Entry
EC 4.2.3.91                 Enzyme                                 

Name
cubebol synthase;
Cop4
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, cubebol-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = cubebol + diphosphate [RN:R09891]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
cubebol [CPD:C20172];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. The enzyme gives 28% cubebol, 29% (-)-germacrene D, 10% (+)-delta-cadinene and traces of several other sesquiterpenoids. See also EC 4.2.3.75 (-)-germacrene D synthase and EC 4.2.3.13 (+)-delta-cadinene synthase.
History
EC 4.2.3.91 created 2011
Reference
1  [PMID:20419721]
  Authors
Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C
  Title
Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers.
  Journal
Chembiochem. 11 (2010) 1093-106.
  Organism
Coprinopsis cinerea [GN:cci]
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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