KEGG   ENZYME: 4.2.3.97Help
Entry
EC 4.2.3.97                 Enzyme                                 

Name
(-)-delta-cadinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-delta-cadinene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate [RN:R09897]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-delta-cadinene [CPD:C20182];
diphosphate [CPD:C00013]
Comment
The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation. Following a 1,3-hydride shift of the original 1-pro-S hydrogen of (2E,6E)-farnesyl diphosphate, cyclization and deprotonation gives (-)-delta-cadinene.
History
EC 4.2.3.97 created 2012
Reference
1  [PMID:21276937]
  Authors
Hu Y, Chou WK, Hopson R, Cane DE
  Title
Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.
  Journal
Chem. Biol. 18 (2011) 32-7.
  Sequence
[up:B5GS26]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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