| Entry |
|
|---|
| Name |
ornithine cyclodeaminase;
ornithine cyclase;
ornithine cyclase (deaminating);
L-ornithine ammonia-lyase (cyclizing) |
|---|
| Class |
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
 |
|---|
| Sysname |
L-ornithine ammonia-lyase (cyclizing; L-proline-forming) |
|---|
| Reaction(IUBMB) |
L-ornithine = L-proline + NH3 [RN:R00671] |
|---|
| Reaction(KEGG) |
R00671
 |
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| Substrate |
L-ornithine [CPD:C00077] |
|---|
| Product |
L-proline [CPD:C00148];
NH3 [CPD:C00014] |
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| Cofactor |
NAD+ [CPD:C00003] |
|---|
| Comment |
Requires NAD+. The enzyme is a member of the mu-crystallin protein
family [4]. The reaction is stimulated by the presence of ADP or ATP
and is inhibited by O2 [2]. |
|---|
| Pathway |
PATH: ec00330 Arginine and proline metabolism |
|---|
| Orthology |
KO: K01750 ornithine cyclodeaminase |
|---|
| Genes |
POP: POPTR_198927
RCU: RCOM_1581990
VVI: 100259461(GSVIVT00037754001)
PPP: PHYPADRAFT_5443
SPO: SPAP11E10.01
AFM: AFUA_6G08780
LBC: LACBIDRAFT_191799
DDI: DDBDRAFT_0191677
TVA: TVAG_419590
PTI: PHATRDRAFT_34775
TPS: THAPSDRAFT_268461
YPE: YPO4090
YPK: y4106
YPM: YP_3998
YPA: YPA_2995
YPN: YPN_3734
YPG: YpAngola_A3799
YPP: YPDSF_0007
YPS: YPTB3900
YPI: YpsIP31758_4147
YPY: YPK_0007
YPB: YPTS_4117
YEN: YE4168
ECA: ECA2039
PCT: PC1_2251
PWA: Pecwa_2557
ETA: ETA_33140
PLU: plu3045
ESA: ESA_01897
CTU: Ctu_20900
CKO: CKO_02930
SPE: Spro_0340 Spro_3024
DDA: Dd703_1184 Dd703_1673
DDC: Dd586_2509
VVY: VV1563
VPA: VP1333
VEX: VEA_000639 VEA_003670
PPR: PBPRB0030
PAE: PA3862 PA4908
PAU: PA14_14020 PA14_64850
PAP: PSPA7_1243 PSPA7_4377(eutC)
PAG: PLES_11121 PLES_52941
PPU: PP_3190 PP_3533 PP_4431
PPF: Pput_2240 Pput_2526
PPG: PputGB1_1891 PputGB1_2392 PputGB1_3516
PPW: PputW619_1731 PputW619_2675
PFL: PFL_1045 PFL_3641(arcB)
PFO: Pfl01_0970
PFS: PFLU1940 PFLU3072 PFLU3970 PFLU5632
PEN: PSEEN1859(arcB) PSEEN2151 PSEEN5012
PMY: Pmen_3566
PAR: Psyc_1391(ocd)
PCR: Pcryo_0899 Pcryo_0978 Pcryo_1795
PRW: PsycPRwf_2173
SDN: Sden_0589
SAZ: Sama_2610
SLO: Shew_2955
SSE: Ssed_3503
SPL: Spea_1610 Spea_3170
SHL: Shal_2647 Shal_3252
SWD: Swoo_3726
SWP: swp_3859
CPS: CPS_1455 CPS_2747 CPS_4886
PHA: PSHAb0543
PIN: Ping_2540
CBU: CBU_1727(arcB)
CBS: COXBURSA331_A1919(arcB)
CBD: CBUD_0275(arcB) CBUD_1706
CBG: CbuG_0108(arcB)
CBC: CbuK_0280(arcB)
LPN: lpg2196
LPF: lpl2120
LPP: lpp2145
LPC: LPC_1659
FTW: FTW_0394
FTL: FTL_0578
FTA: FTA_0612
FTN: FTN_1444
FPH: Fphi_1230
CSA: Csal_2722
MMW: Mmwyl1_0204 Mmwyl1_0461 Mmwyl1_1840 Mmwyl1_3082 Mmwyl1_3168
CVI: CV_3249(ocd)
RSO: RS00361(RSp0483) RS00875(RSp0418) RSc3352
RPI: Rpic_3546
RPF: Rpic12D_3222
REU: Reut_A2671 Reut_A3381 Reut_B3761 Reut_B5760
REH: H16_A0689 H16_A1394(arcB) H16_A3673 H16_B1881
RME: Rmet_0586 Rmet_1116 Rmet_3527 Rmet_3634 Rmet_4824
CTI: RALTA_A0646 RALTA_A3129 RALTA_B1580
BMA: BMAA1290
BMV: BMASAVP1_0266
BML: BMA10229_0536
BMN: BMA10247_A1031
BPS: BPSS0940
BPM: BURPS1710b_A2543
BPL: BURPS1106A_A1291
BPD: BURPS668_A1371
BTE: BTH_II1457
BVI: Bcep1808_4040 Bcep1808_4889 Bcep1808_5463 Bcep1808_6676
BUR: Bcep18194_A3938 Bcep18194_B1663 Bcep18194_B2542 Bcep18194_B2555
Bcep18194_B2946 Bcep18194_C6879
BCN: Bcen_0365 Bcen_4010 Bcen_5804
BCH: Bcen2424_0848 Bcen2424_3568 Bcen2424_3577 Bcen2424_4357
Bcen2424_6168
BCM: Bcenmc03_0820 Bcenmc03_3943 Bcenmc03_3952 Bcenmc03_5997
Bcenmc03_6649
BCJ: BCAL0774 BCAL3157 BCAM0592 BCAM0604 BCAM1485 BCAS0026
BAM: Bamb_0723 Bamb_3766 Bamb_5302 Bamb_5311 Bamb_6019
BAC: BamMC406_0740 BamMC406_3483 BamMC406_3492 BamMC406_4240
BamMC406_4650 BamMC406_5775
BMU: Bmul_2539 Bmul_4263 Bmul_6144
BMJ: BMULJ_00699 BMULJ_04243(ocd) BMULJ_05386(ocd)
BXE: Bxe_A1829 Bxe_B1765 Bxe_C0057
BPH: Bphy_3343 Bphy_3431 Bphy_3863
BPY: Bphyt_2072 Bphyt_3715 Bphyt_4227 Bphyt_4907
BGL: bglu_2g01020 bglu_2g05540 bglu_2g07030
BPE: BP0354 BP1505
BPA: BPP1970 BPP2191 BPP4178
BBR: BB1012 BB1588 BB2158 BB4648
BPT: Bpet0287 Bpet0748 Bpet2827
BAV: BAV0458(arcB) BAV0655 BAV1400
RFR: Rfer_0976 Rfer_3226 Rfer_3883
POL: Bpro_1163 Bpro_1386 Bpro_2024 Bpro_4333 Bpro_4602 Bpro_5200
PNA: Pnap_3771
AAV: Aave_0121 Aave_0151 Aave_3400
AJS: Ajs_0613
VEI: Veis_1338 Veis_2150 Veis_4197
DAC: Daci_0682 Daci_2152
DIA: Dtpsy_0592
VAP: Vapar_4424 Vapar_4693
CTT: CtCNB1_3667 CtCNB1_4177
MPT: Mpe_A1509
LCH: Lcho_0279 Lcho_4344
NET: Neut_2213
EBA: ebA4164(ocd)
DAR: Daro_3361
TMZ: Tmz1t_0586
APP: CAP2UW1_0658
PCA: Pcar_0765
DMA: DMR_28030(ocd)
DBA: Dbac_1146
MXA: MXAN_7463
SCL: sce2388(ocd)
HOH: Hoch_2639
MLO: mll6776 mlr1729 mlr3204 mlr7139
MES: Meso_2974 Meso_3311 Meso_3962 Meso_4368
SME: SM_b20433 SM_b21494(ocd) SMa0486 SMa1871
SMD: Smed_3694 Smed_5460
ATU: Atu3949(arcB) Atu4008(arcB*) Atu4758(arcB) Atu6016(ocd)
ATC: AGR_L_1687 AGR_L_1691 AGR_L_1807 AGR_L_247 AGR_pTi_54(ocd)
ARA: Arad_0078(ocdch1) Arad_10025(ocdch2) Arad_14151
Arad_7229(ocdch1) Arad_8390(ocdch2) Arad_8446
AVI: Avi_0068(arcB) Avi_5979(ocd) Avi_7398
RET: RHE_CH00058(ocdch1) RHE_CH02026(ocdch2) RHE_CH02594(ypch00875)
RHE_PF00181(ocdF)
REC: RHECIAT_CH0000061(ocdch) RHECIAT_CH0002718
RHECIAT_PC0000375(ocdC)
RLE: RL0060 RL3003(arcB) RL3095(arcB) RL4459(ocd) pRL120053(arcB)
pRL120751
RLT: Rleg2_2245 Rleg2_4418 Rleg2_5520
RLG: Rleg_2556 Rleg_3992 Rleg_4320 Rleg_5241
RHI: NGR_b06500 NGR_b18880(ocd1) NGR_b19520(ocd3) NGR_b23260(ocd2)
NGR_c34200
BME: BMEII0397
BMI: BMEA_B0880
BMF: BAB2_0338
BMB: BruAb2_0334(arcB)
BMC: BAbS19_II03200
BMS: BRA0899(arcB)
BMT: BSUIS_B0892
BOV: BOV_A0842(arcB)
BCS: BCAN_B0918(arcB)
BMR: BMI_II893(arcB)
OAN: Oant_1471 Oant_3468 Oant_4593
RPC: RPC_1858
XAU: Xaut_3506
AZC: AZC_2010
MEX: Mext_2802
MEA: Mex_1p3003(arcB)
MDI: METDI3569(arcB)
MRD: Mrad2831_1539 Mrad2831_6207
MET: M446_1826 M446_2503
MPO: Mpop_2926
MCH: Mchl_3030
MNO: Mnod_1216 Mnod_2200 Mnod_3126 Mnod_3998 Mnod_6949 Mnod_7814
SIL: SPO1141 SPO2121(arcB) SPO3821 SPO3832 SPOA0147
SIT: TM1040_1163 TM1040_2670 TM1040_2702
RSP: RSP_0854
RSH: Rsph17029_2513
RSQ: Rsph17025_3121 Rsph17025_3176
RSK: RSKD131_2224
JAN: Jann_0054 Jann_2605
RDE: RD1_0323 RD1_1415(arcB) RD1_2889
PDE: Pden_0286 Pden_1185 Pden_3918 Pden_4637
DSH: Dshi_0890 Dshi_2310
HNE: HNE_2590
HBA: Hbal_2672
ZMO: ZMO1975
ZMN: Za10_1195
SWI: Swit_1052 Swit_1566 Swit_1590 Swit_1715 Swit_2415 Swit_3083
Swit_3763 Swit_4262
APT: APA01_08140
RRU: Rru_A2867
BAN: BA0902
BAR: GBAA0902
BAA: BA_1484
BAT: BAS0854
BAH: BAMEG_3660
BAI: BAA_1005
BCE: BC0906
BCA: BCE_0995
BCZ: BCZK0803(arcB)
BCR: BCAH187_A1083
BCB: BCB4264_A0944
BCU: BCAH820_0990
BCG: BCG9842_B4387
BCQ: BCQ_0989(arcB)
BCX: BCA_0953
BCY: Bcer98_2042
BTK: BT9727_0800(arcB)
BTL: BALH_0814
BWE: BcerKBAB4_0801
BCL: ABC1182
GTN: GTNG_0807 GTNG_2271
GYC: GYMC61_1709
SAU: SA0113
SAV: SAV0117
SAW: SAHV_0116
SAM: MW0090
SAR: SAR0120
SAS: SAS0091
SAC: SACOL0101
SAB: SAB0056
SAA: SAUSA300_0119
SAX: USA300HOU_0128(ocd)
SAO: SAOUHSC_00076
SAJ: SaurJH9_0104
SAH: SaurJH1_0108
SAE: NWMN_0061(sbnB)
SAD: SAAV_0085 SAAV_2008
SEP: SE0315
SER: SERP0192
SHA: SH2453
SSP: SSP2196
SCA: Sca_0751
MCL: MCCL_0345
BBE: BBR47_31890 BBR47_45350 BBR47_49420
PJD: Pjdr2_0605 Pjdr2_5191
LLM: llmg_1149(ocd)
LSL: LSL_1273
LCA: LSEI_0332
LCB: LCABL_03540
LFE: LAF_0928
EFA: EF0118 EF0616
CDF: CD0544
CDC: CD196_0259 CD196_0484
CDL: CDR20291_0246 CDR20291_0469
CBO: CBO2575
CBA: CLB_2516
CBH: CLC_2447
CBY: CLM_2882
CBL: CLK_0333 CLK_1553 CLK_1960
CBB: CLD_1990
CBI: CLJ_B2805
CBF: CLI_2638
CGL: NCgl1520(cgl1582)
CGB: cg1784(ocd)
CGT: cgR_1630
CEF: CE1700 CE2115(ocd)
CJK: jk1979(ocd)
CUR: cur_1276(ocd)
CAR: cauri_1343(arcB)
RHA: RHA1_ro04990
SMA: SAV_1790(arcB1) SAV_3645(arcB2) SAV_5617(arcB3) SAV_7163(arcB4)
SGR: SGR_1623 SGR_2591 SGR_3243 SGR_560
ART: Arth_3596
KRH: KRH_11610
MLU: Mlut_03150
BFA: Bfae_06630
KSE: Ksed_04330
XCE: Xcel_3303
PAC: PPA1289
NCA: Noca_0072 Noca_0691 Noca_1414
TCU: Tcur_1883
SRO: Sros_0322 Sros_3754 Sros_5043 Sros_5996
NML: Namu_3876
SEN: SACE_3017(arcB4) SACE_3879(arcB1) SACE_4281(arcB4)
AMI: Amir_2564 Amir_3585
STP: Strop_0460 Strop_1041 Strop_1395
SAQ: Sare_0367 Sare_1353
CAI: Caci_1976
RXY: Rxyl_2097 Rxyl_2927
AFO: Afer_1821
SHI: Shel_13720
TDE: TDE2754(arcB)
SUS: Acid_1837 Acid_2302 Acid_5671
PDI: BDI_1464
GAU: GAU_3810
TAI: Taci_0365
DEH: cbdb_A155(arcB)
DEV: DhcVS_140(arcB)
RRS: RoseRS_1351
RCA: Rcas_3909
CAU: Caur_2849
CAG: Cagg_1111
CHL: Chy400_3086
HAU: Haur_1864
TRO: trd_0794
STI: Sthe_1236
DDR: Deide_3p02181 Deide_3p02410
TTR: Tter_0841
MAC: MA3252(ocd)
MBA: Mbar_A3192
MMA: MM_0097
MHU: Mhun_1928
MEM: Memar_1004
MBN: Mboo_0844
MPD: MCP_0327
MSI: Msm_1517
MKA: MK1411
HAL: VNG1364G(ocd2) VNG2224G(ocd1)
HSL: OE2945F(ocd2) OE4121R(ocd1)
HMA: rrnAC0038(ocd1) rrnAC0227(ocd3) rrnAC2941(ocd2)
HWA: HQ1386A(ocd) HQ1803A(ocd) HQ2237A(ocd)
NPH: NP0448A(arcB) NP3802A
HLA: Hlac_0439 Hlac_2032
HUT: Huta_1639
HMU: Hmuk_0978 Hmuk_2787
TAC: Ta0480
TVO: TVN0824
PTO: PTO0381
TSI: TSIB_0634
RCI: RCIX1588(arcB)
APE: APE_0916.1(ocd)
SSO: SSO0378(ocd-like1)
STO: ST2179
SAI: Saci_2372
SIS: LS215_1866
SIA: M1425_1726
SIM: M1627_1844
SID: M164_1773
SIY: YG5714_1842
SIN: YN1551_1083
MSE: Msed_1799
PAI: PAE2445
PIS: Pisl_1900
PCL: Pcal_0300
PAS: Pars_1433
CMA: Cmaq_0244 Cmaq_1163
TNE: Tneu_1192
TPE: Tpen_0208
KCR: Kcr_0796
 |
|---|
| Structures |
PDB: 1U7H 1X7D |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4399881]
Costilow RN, Laycock L.
Ornithine cyclase (deaminating). Purification of a protein that
converts ornithine to proline and definition of the optimal assay
conditions.
J. Biol. Chem. 246 (1971) 6655-60.
Clostridium sporogenes |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4373469]
Muth WL, Costilow RN.
Ornithine cyclase (deaminating). II. Properties of the homogeneous
enzyme.
J. Biol. Chem. 249 (1974) 7457-62.
Clostridium sporogenes |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10468639]
Espineda CE, Linford AS, Devine D, Brusslan JA.
The AtCAO gene, encoding chlorophyll a oxygenase, is required for
chlorophyll b synthesis in Arabidopsis thaliana.
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10507-11.
Arabidopsis thaliana [GN:ath] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:15518536]
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE.
Ornithine cyclodeaminase: structure, mechanism of action, and
implications for the mu-crystallin family.
Biochemistry. 43 (2004) 13883-91.
Pseudomonas putida [GN:ppu] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:15103146]
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE.
Crystallization and X-ray diffraction analysis of ornithine
cyclodeaminase from Pseudomonas putida.
Acta. Crystallogr. D. Biol. Crystallogr. 60 (2004) 941-4.
Pseudomonas putida [GN:ppu] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.3.1.12
IUBMB Enzyme Nomenclature: 4.3.1.12
ExPASy - ENZYME nomenclature database: 4.3.1.12
BRENDA, the Enzyme Database: 4.3.1.12
CAS: 9054-76-6 |
|---|
