| Entry |
|
|---|
| Name |
D-serine ammonia-lyase;
D-hydroxyaminoacid dehydratase;
D-serine dehydrase;
D-hydroxy amino acid dehydratase;
D-serine hydrolase;
D-serine dehydratase (deaminating);
D-serine deaminase;
D-serine hydro-lyase (deaminating) |
|---|
| Class |
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
 |
|---|
| Sysname |
D-serine ammonia-lyase (pyruvate-forming) |
|---|
| Reaction(IUBMB) |
D-serine = pyruvate + NH3 [RN:R00221] |
|---|
| Reaction(KEGG) |
R00221;
(other) R06131
 |
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| Substrate |
D-serine [CPD:C00740] |
|---|
| Product |
pyruvate [CPD:C00022];
NH3 [CPD:C00014] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. Also acts, slowly, on D-threonine.
The reaction catalysed probably involves initial elimination of
water (hence the enzyme's original classification as EC 4.2.1.14,
D-serine dehydratase), followed by isomerization and hydrolysis of
the product with C-N bond breakage. |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism |
|---|
| Orthology |
KO: K01753 D-serine dehydratase |
|---|
| Genes |
ECO: b2366(dsdA)
ECJ: JW2363(dsdA)
ECD: ECDH10B_2531(dsdA)
EBW: BWG_2134(dsdA)
ECE: Z3628(dsdA)
ECS: ECs3245
ECF: ECH74115_3597(dsdA)
ETW: ECSP_3315(dsdA)
ECC: c2901(dsdA)
ECI: UTI89_C2697(dsdA) UTI89_C4955
ECP: ECP_2391 ECP_4590
ECV: APECO1_4170(dsdA)
ECW: EcE24377A_2652(dsdA)
ECX: EcHS_A2503(dsdA)
ECM: EcSMS35_2516(dsdA)
ECY: ECSE_2663
ECL: EcolC_1303
ECK: EC55989_2659(dsdA)
ECQ: ECED1_2813(dsdA)
ECR: ECIAI1_2431(dsdA)
ECT: ECIAI39_2509(dsdA)
ECZ: ECS88_2560(dsdA)
EUM: ECUMN_2695(dsdA)
ELF: LF82_0525(dsdA)
EBL: B21_02237(dsdA)
EBD: ECBD_1306
EBR: ECB_02276(dsdA)
EOH: ECO103_2891(dsdA)
EOJ: ECO26_3426(dsdA)
EFE: EFER_3973(dsdA)
STY: STY3977(dsdA)
STT: t3715(dsdA)
SPT: SPA3653(dsdA)
SEK: SSPA3411
SPQ: SPAB_04730
SEI: SPC_3885(dsdA)
SEC: SC3724(dsdA)
SEH: SeHA_C4132(dsdA)
SEE: SNSL254_A4082(dsdA)
SEW: SeSA_A4011(dsdA)
SEA: SeAg_B4027(dsdA)
SED: SeD_A4190(dsdA)
SEG: SG3630(dsdA)
SET: SEN3619(dsdA)
SES: SARI_03847
STM: STM3802(dsdA)
YEN: YE0800(dsdA)
SFL: SF2433(dsdA)
SFX: S2570(dsdA)
SFV: SFV_2425(dsdA)
SSN: SSON_2457(dsdA)
SBO: SBO_2392(dsdA)
SBC: SbBS512_E2735(dsdA)
SDY: SDY_2561(dsdA)
PLU: plu1970(dsdA)
PAY: PAU_02598(dsdA)
ENT: Ent638_0021
KPN: KPN_04081(dsdA)
KPE: KPK_0019(dsdA)
KPU: KP1_5458(dsdA)
CKO: CKO_00021
SPE: Spro_2515
PMR: PMI0187(dsdA)
ETR: ETAE_0848(dsdA)
DDA: Dd703_3934
DDC: Dd586_4103
DZE: Dd1591_4129
HSO: HS_1718(dsdA)
HSM: HSM_1892
VCH: VCA0875
VCO: VC0395_0362(dsdA)
VCM: VCM66_A0834(dsdA)
VCJ: VCD_000458
VPA: VP1248
VHA: VIBHAR_02609
VSP: VS_II0841
VEX: VEA_003747
PPR: PBPRB1408
PAE: PA3357(dsdA)
PAU: PA14_20650(dsdA)
PAP: PSPA7_1773(dsdA)
PAG: PLES_17071(dsdA)
PPF: Pput_3070
PPG: PputGB1_3112
PMY: Pmen_3266
CJA: CJA_0345(dsd)
ACI: ACIAD1048(dsdA)
ACB: A1S_0973
ABY: ABAYE2819(dsdA)
ABC: ACICU_00935
ABN: AB57_1052(dsdA)
SPL: Spea_3449
SHL: Shal_3561
CPS: CPS_4659(dsdA)
HCH: HCH_02978(dsdA)
MMW: Mmwyl1_3826
AHA: AHA_1438(dsdA)
ASA: ASA_2940(dsdA)
CVI: CV_2648(dsdA)
RSO: RSp1185(dsd)
RPI: Rpic_4197
RPF: Rpic12D_4307
REU: Reut_A2915 Reut_B4022
REH: H16_B1211
RME: Rmet_4770
CTI: RALTA_B1122
BMA: BMA0176
BMV: BMASAVP1_1576 BMASAVP1_1577 BMASAVP1_A2772
BML: BMA10229_1762 BMA10229_1763 BMA10229_A2307
BMN: BMA10247_2387 BMA10247_A0431
BPS: BPSL0628 BPSS2116(dsdA)
BPM: BURPS1710b_0834(dsd) BURPS1710b_A1220(dsdA)
BPL: BURPS1106A_0672 BURPS1106A_A2856(dsdA)
BPD: BURPS668_0656 BURPS668_A2980(dsdA)
BPR: GBP346_A0584
BTE: BTH_I0544 BTH_II0245(dsdA)
BVI: Bcep1808_2847 Bcep1808_3327
BUR: Bcep18194_A6070 Bcep18194_B1364
BCN: Bcen_2130
BCH: Bcen2424_2742
BCM: Bcenmc03_2768
BCJ: BCAL0864
BAM: Bamb_2792
BAC: BamMC406_2659
BMU: Bmul_0557
BMJ: BMULJ_02704(dsdA)
BXE: Bxe_A4060
BPH: Bphy_0364
BPY: Bphyt_0639
BGL: bglu_1g30920
BPT: Bpet1585(dsd)
BAV: BAV2693(dsd)
RFR: Rfer_0929
POL: Bpro_0661
PNA: Pnap_4614
AAV: Aave_2428
AJS: Ajs_2250
VEI: Veis_3329
DAC: Daci_0845
DIA: Dtpsy_1624
VAP: Vapar_1219
CTT: CtCNB1_4379
LCH: Lcho_0086
DMA: DMR_17260(dsdA)
DRT: Dret_1151
MLO: mll6666
SMD: Smed_2092
RET: RHE_PC00175(yhc00041)
REC: RHECIAT_CH0002054
RLE: pRL100420
RLT: Rleg2_1621
RLG: Rleg_6379
MRD: Mrad2831_0232
SWI: Swit_1425
BSU: BSU23770(dsdA)
BHA: BH1762(dsdA)
BAN: BA1784(dsdA)
BAR: GBAA1784(dsdA)
BAA: BA_2290
BAT: BAS1653
BAH: BAMEG_2806(dsdA)
BAI: BAA_1856(dsdA)
BCE: BC1725
BCA: BCE_1855(dsdA)
BCZ: BCZK1600(dsdA)
BCR: BCAH187_A1907(dsdA)
BCB: BCB4264_A1796(dsdA)
BCU: BCAH820_1833(dsdA)
BCG: BCG9842_B3545(dsdA)
BCQ: BCQ_1792(dsdA)
BCX: BCA_1793(dsdA)
BCY: Bcer98_2017
BTK: BT9727_1631(dsdA)
BTL: BALH_1568
BWE: BcerKBAB4_1650
BCL: ABC1954(dsdA)
BAY: RBAM_021900(dsdA)
GKA: GK1922(dsdA)
GTN: GTNG_1833
GYC: GYMC61_2763
SSP: SSP0432
LSP: Bsph_2154
BBE: BBR47_25430(dsdA)
LPL: lp_2776(dsdA)
LPJ: JDM1_2228(dsdA)
LFE: LAF_0744
PPE: PEPE_1745
OOE: OEOE_0657
AOE: Clos_0664
DSY: DSY1743
DHD: Dhaf_2895
DRM: Dred_0329
CHY: CHY_0067(dsdA)
CPO: COPRO5265_1590(dsdA)
CUR: cur_1755(dsdA)
KRH: KRH_22290(dsdA)
ACA: ACP_0035
FNU: FN0553
 |
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| Structures |
PDB: 3GWQ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:5327100]
Dupourque D, Newton WA, Snell EE.
Purification and properties of D-serine dehydrase from Escherichia
coli.
J. Biol. Chem. 241 (1966) 1233-8.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:12999751]
METZLER DE, SNELL EE.
Deamination of serine. II. D-Serine dehydrase, a vitamin B6 enzyme
from Escherichia coli.
J. Biol. Chem. 198 (1952) 363-73.
Escherichia coli [GN:eco] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 4.3.1.18
IUBMB Enzyme Nomenclature: 4.3.1.18
ExPASy - ENZYME nomenclature database: 4.3.1.18
BRENDA, the Enzyme Database: 4.3.1.18
CAS: 9015-88-7 |
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