| Entry |
|
|---|
| Name |
histidine ammonia-lyase;
histidase;
histidinase;
histidine alpha-deaminase;
L-histidine ammonia-lyase |
|---|
| Class |
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
 |
|---|
| Sysname |
L-histidine ammonia-lyase (urocanate-forming) |
|---|
| Reaction(IUBMB) |
L-histidine = urocanate + NH3 [RN:R01168] |
|---|
| Reaction(KEGG) |
R01168;
(other) R06132
 |
|---|
| Substrate |
L-histidine [CPD:C00135] |
|---|
| Product |
urocanate [CPD:C00785];
NH3 [CPD:C00014] |
|---|
| Comment |
This enzyme is a member of the aromatic amino acid lyase family,
other members of which are EC 4.3.1.23 (tyrosine ammonia-lyase), EC
4.3.1.24 (phenylalanine ammonia-lyase) and EC 4.3.1.25
(phenylalanine/tyrosine ammonia-lyase). The enzyme contains the
cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is
common to this family [4]. This unique cofactor is formed
autocatalytically by cyclization and dehydration of the three
amino-acid residues alanine, serine and glycine [5]. This enzyme
catalyses the first step in the degradation of histidine and the
product, urocanic acid, is further metabolized to glutamate [2,3]. |
|---|
| Pathway |
PATH: ec00340 Histidine metabolism
PATH: ec00910 Nitrogen metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01745 histidine ammonia-lyase |
|---|
| Genes |
HSA: 3034(HAL)
PTR: 452144(HAL)
MCC: 712963(HAL)
MMU: 15109(Hal)
RNO: 29301(Hal)
CFA: 475433(HAL)
BTA: 615205(HAL)
SSC: 100154617
ECB: 100052193
MDO: 100012617
OAA: 100073767
GGA: 378924(HAL)
TGU: 100227237
XLA: 100125662 444493 446479(hal)
XTR: 100145719(hal) 448568(hal)
DRE: 100004331
BFO: BRAFLDRAFT_209115
CIN: 100184467
SPU: 583726
TCA: 664601
ISC: IscW_ISCW012913
CEL: F47B10.2
CBR: CBG17560
NVE: NEMVE_v1g160941
HMG: 100198504
TAD: TRIADDRAFT_22772
DDI: DDB_0231727
PTM: GSPATT00002029001 GSPATT00017547001
TCR: 506247.220
ECT: ECIAI39_0694(hutH)
STY: STY0824(hutH)
STT: t2096(hutH)
SPT: SPA1961(hutH)
SEK: SSPA1829
SPQ: SPAB_02728
SEI: SPC_0787(hutH)
SEC: SC0789(hutH)
SEH: SeHA_C0918(hutH)
SEE: SNSL254_A0855(hutH)
SEW: SeSA_A0941(hutH)
SEA: SeAg_B0827(hutH)
SED: SeD_A0886(hutH)
SEG: SG0769(hutH)
SET: SEN0736(hutH)
SES: SARI_02135
STM: STM0791(hutH)
YPE: YPO4016(hutH)
YPK: y4037(hutH)
YPM: YP_3379(hutH)
YPA: YPA_4104
YPN: YPN_3664
YPG: YpAngola_A4137(hutH)
YPP: YPDSF_3759
YPS: YPTB3851(hutH)
YPI: YpsIP31758_4085(hutH)
YPY: YPK_0077
YPB: YPTS_4069
YEN: YE4094(hutH)
PWA: Pecwa_4557
ETA: ETA_22240(hutH)
PLU: plu3192(hutH)
PAY: PAU_01424(hutH)
ENT: Ent638_1264
KPN: KPN_00796(hutH)
KPE: KPK_1797 KPK_3142 KPK_3777(hutH)
KPU: KP1_1746(hutH)
CKO: CKO_02356 CKO_02926
SPE: Spro_0799 Spro_0804
DDA: Dd703_2642 Dd703_2648
DDC: Dd586_2945 Dd586_2954
DZE: Dd1591_1260 Dd1591_1264
XCC: XCC1579(hutH)
XCB: XC_2655(hutH)
XCA: xccb100_2681
XCV: XCV1678(hutH)
XAC: XAC1637(hutH)
XOO: XOO2398(hutH)
XOM: XOO_2278
XOP: PXO_00727(hutH)
SML: Smlt3108(hutH1) Smlt4565
SMT: Smal_2550 Smal_3917
VCH: VC1202(hutH)
VCO: VC0395_A0822(hutH)
VCM: VCM66_1157(hutH)
VCJ: VCD_003142
VVU: VV1_0053 VV1_2389(hutH)
VVY: VV1074 VV1952(hutH)
VPA: VP0889 VP1273(hutH)
VHA: VIBHAR_02072
VSP: VS_0779 VS_1216
VEX: VEA_003723 VEA_004070
VFI: VF_0852 VF_A0450(hutH)
VFM: VFMJ11_0890 VFMJ11_A0500(hutH)
VSA: VSAL_I2097 VSAL_II0708(hutH)
PPR: PBPRA2173(hutH) PBPRB0112
PAE: PA5093 PA5098(hutH)
PAU: PA14_67260 PA14_67320(hutH)
PAP: PSPA7_5827(hutH2) PSPA7_5831(hutH1)
PAG: PLES_54831 PLES_54881(hutH)
PPU: PP_5032(hutH)
PPF: Pput_4906
PPG: PputGB1_5082
PPW: PputW619_0432
PST: PSPTO_5099(hutH-1) PSPTO_5274(hutH-2) PSPTO_5275(hutH-3)
PSB: Psyr_4832 Psyr_4833(hutH)
PSP: PSPPH_0422 PSPPH_4864(hutH1) PSPPH_4865(hutH2)
PFL: PFL_0406(hutH) PFL_0407(hutH) PFL_0472
PFO: Pfl01_0365 Pfl01_0366 Pfl01_0433
PFS: PFLU0366 PFLU0367(hutH) PFLU0430
PEN: PSEEN0356 PSEEN2604(hutH-2) PSEEN5096(hutH)
PMY: Pmen_4069
AVN: Avin_26290(hutH)
PCR: Pcryo_1932
PRW: PsycPRwf_0850
ACI: ACIAD0574(hutH)
ACB: A1S_0515 A1S_3405
ABM: ABSDF3583(hutH)
ABY: ABAYE0076(hutH)
ABC: ACICU_00525 ACICU_03601
ABN: AB57_3859(hutH)
ABB: ABBFA_000077(hutH)
SON: SO_0098(hutH) SO_3057 SO_4374
SDN: Sden_0084
SFR: Sfri_0346 Sfri_3952
SAZ: Sama_1631 Sama_3385
SBL: Sbal_0336 Sbal_4251
SBM: Shew185_0098 Shew185_0334
SBN: Sbal195_0103 Sbal195_0341
SBP: Sbal223_0103 Sbal223_0344
SLO: Shew_2280 Shew_3517 Shew_3756
SPC: Sputcn32_0080 Sputcn32_0440 Sputcn32_2431
SSE: Ssed_0319 Ssed_0343 Ssed_4446
SPL: Spea_3369 Spea_3894 Spea_4168
SHE: Shewmr4_0100 Shewmr4_0344
SHM: Shewmr7_0095 Shewmr7_3682
SHN: Shewana3_0101 Shewana3_0335 Shewana3_1490
SHW: Sputw3181_0294 Sputw3181_1577 Sputw3181_3997
SHL: Shal_0074 Shal_0375 Shal_3448
SWD: Swoo_3913 Swoo_4602 Swoo_4837
SWP: swp_0134 swp_0298
ILO: IL0134(hutH_1) IL2450(hutH_2)
CPS: CPS_0908(hutH)
PHA: PSHAa2740(hutH) PSHAb0401
PAT: Patl_1022
AMC: MADE_03126
PIN: Ping_1029
LPN: lpg1380
LPF: lpl1331(hutH)
LPP: lpp1335(hutH)
LPC: LPC_0796(hutH)
HCH: HCH_04172(hutH)
MMW: Mmwyl1_3901
AHA: AHA_0380(hutH) AHA_3390
ASA: ASA_0916 ASA_3952(hutH)
KKO: Kkor_1533 Kkor_2580
CVI: CV_0325(hutH)
RSO: RSc2646(hutH) RSp0365(hutH2)
RPI: Rpic_2880 Rpic_4767
RPF: Rpic12D_2474 Rpic12D_3690
REU: Reut_A2716 Reut_B5637
REH: H16_A3018(hutH)
RME: Rmet_0231 Rmet_2855 Rmet_5047
CTI: RALTA_A2492(hutH)
BMA: BMA0645(hutH)
BMV: BMASAVP1_A2366(hutH)
BML: BMA10229_A2919(hutH)
BMN: BMA10247_1681(hutH)
BPS: BPSL1676 BPSL2344(hutH)
BPM: BURPS1710b_2187 BURPS1710b_2796(hutH)
BPL: BURPS1106A_2045 BURPS1106A_2723(hutH)
BPD: BURPS668_2667(hutH)
BPR: GBP346_A2097 GBP346_A2846(hutH)
BTE: BTH_I1820(hutH)
BVI: Bcep1808_2247 Bcep1808_5573 Bcep1808_5960
BUR: Bcep18194_A5482 Bcep18194_B3018
BCN: Bcen_5747 Bcen_5905
BCH: Bcen2424_2172 Bcen2424_6111
BCM: Bcenmc03_2189 Bcenmc03_6593
BCJ: BCAL2246(hutH) BCAS0114
BAM: Bamb_2211 Bamb_3604 Bamb_5836
BAC: BamMC406_2088 BamMC406_4079 BamMC406_5619
BMU: Bmul_1098
BMJ: BMULJ_02158(hutH)
BXE: Bxe_A0933 Bxe_A1482 Bxe_A2947 Bxe_B0058 Bxe_B1825
BPH: Bphy_0696 Bphy_1814 Bphy_5104
BPY: Bphyt_1530 Bphyt_3058 Bphyt_4838
BGL: bglu_1g18020 bglu_1g25210
POL: Bpro_1043 Bpro_1157 Bpro_1160 Bpro_5198
AAV: Aave_2965
VEI: Veis_3645
DAC: Daci_0149
VAP: Vapar_0158
CTT: CtCNB1_0164
MMS: mma_0515(hutH)
EBA: ebA5742(hutH)
CFF: CFF8240_0134
SDL: Sdel_2100
BBA: Bd2753(hutH)
DPS: DP2353
DAT: HRM2_44120(hutH)
ADE: Adeh_1814
ACP: A2cp1_2116
AFW: Anae109_2013
ANK: AnaeK_2046
MXA: MXAN_3465(hutH)
SCL: sce6082(hutH)
HOH: Hoch_3903
SFU: Sfum_2378
MLO: mll0151 mll7124 mlr1730 mlr8321(hutH)
MES: Meso_2540 Meso_2628 Meso_2632 Meso_2978 Meso_2985
PLA: Plav_1493
SME: SM_b21165(hutH) SMa0306 SMc00669(hutH2)
SMD: Smed_2586 Smed_4658
ATU: Atu3803(hutH) Atu3933(hutH)
ATC: AGR_L_1400GM AGR_L_1825(hutH)
ARA: Arad_0592(hutHch) Arad_4563(hutH) Arad_4568(hutH)
Arad_8393(hutH)
AVI: Avi_0506(hutH) Avi_5958(hutH) Avi_7540(hutH)
RET: RHE_CH00352(hutHch) RHE_PE00072(hutHe1) RHE_PE00081(hutHe2)
REC: RHECIAT_CH0000390(hutHch) RHECIAT_PA0000078(hutHa1)
RHECIAT_PA0000088(hutHa2)
RLE: RL0369(hutH) RL4470(hutH) pRL110205(hutH1) pRL110215(hutH2)
pRL120749
RLT: Rleg2_4365 Rleg2_5918 Rleg2_5927
RLG: Rleg_4004 Rleg_4636 Rleg_6911 Rleg_6923
RHI: NGR_b13260 NGR_c27430
BME: BMEII0367
BMF: BAB2_0305(hutH)
BMB: BruAb2_0303(hutH)
BMC: BAbS19_II02890
BMS: BRA0930(hutH)
BMT: BSUIS_B0923(hutH)
BOV: BOV_A0872(hutH)
BCS: BCAN_B0950(hutH)
BMR: BMI_II924(hutH)
OAN: Oant_1435
BJA: bll6242(hutH)
BRA: BRADO1604(hutH)
BBT: BBta_6451(hutH)
BHE: BH06500(hutH)
BQU: BQ06730(hutH)
BTR: Btr_1465(hutH)
BGR: Bgr_12580(hutH)
XAU: Xaut_1004
MET: M446_0175 M446_1653
MNO: Mnod_1038
CCR: CC_0959(hutH)
CCS: CCNA_01010
CAK: Caul_1297
PZU: PHZ_c0466(hutH)
SIL: SPO2192(hutH)
SIT: TM1040_3005
RSP: RSP_2935(hutH)
RSH: Rsph17029_1579
RSK: RSKD131_1252
RDE: RD1_3678(hutH)
PDE: Pden_0711 Pden_3519
MMR: Mmar10_1603
HNE: HNE_2396(hutH)
HBA: Hbal_1315
SAL: Sala_1689
SWI: Swit_4632
GOX: GOX1167(hutH)
ACR: Acry_1747
GDI: GDI_0550(hutH)
GDJ: Gdia_1458
RRU: Rru_A1301
RCE: RC1_3238(hutH)
BSU: BSU39350(hutH)
BHA: BH1982(hutH)
BAN: BA3712(hutH)
BAR: GBAA3712(hutH)
BAA: BA_4195
BAT: BAS3442(hutH)
BAH: BAMEG_0922(hutH)
BAI: BAA_3739(hutH)
BCE: BC3652(hutH)
BCA: BCE_3680(hutH)
BCZ: BCZK3354(hutH)
BCR: BCAH187_A3685(hutH)
BCB: BCB4264_A3760(hutH)
BCU: BCAH820_3662(hutH)
BCG: BCG9842_B1556(hutH)
BCQ: BCQ_3452(hutH)
BCX: BCA_3746(hutH)
BCY: Bcer98_2312
BTK: BT9727_3405(hutH)
BTL: BALH_3287
BWE: BcerKBAB4_3339
BCL: ABC3933(hutH)
BAY: RBAM_036410(hutH)
GKA: GK0385(hutH)
GTN: GTNG_0362
GWC: GWCH70_0281
GYC: GYMC61_1265
SAU: SA0008(hutH)
SAV: SAV0008(hutH)
SAW: SAHV_0008(hutH)
SAM: MW0008(hutH)
SAR: SAR0008(hutH)
SAS: SAS0008(hutH)
SAC: SACOL0008(hutH)
SAB: SAB0008(hutH)
SAA: SAUSA300_0008(hutH)
SAX: USA300HOU_0008(hutH)
SAO: SAOUHSC_00008
SAJ: SaurJH9_0008
SAH: SaurJH1_0008
SAE: NWMN_0007(hutH)
SAD: SAAV_0008(hutH)
SSP: SSP0008
SCA: Sca_2466(hutH)
LSP: Bsph_0718
MCL: MCCL_1401(hutH)
BBE: BBR47_21400(hutH)
SPY: SPy_2089(hutH)
SPZ: M5005_Spy_1777(hutH)
SPM: spyM18_2147(hutH)
SPG: SpyM3_1779(hutH)
SPS: SPs1776(hutH)
SPH: MGAS10270_Spy1843(hutH)
SPI: MGAS10750_Spy1869(hutH)
SPJ: MGAS2096_Spy1810(hutH)
SPK: MGAS9429_Spy1788(hutH)
SPF: SpyM51735(hutH)
SPA: M6_Spy1774(hutH) M6_Spy1775
SPB: M28_Spy1761(hutH)
SOZ: Spy49_1730(hutH)
STC: str1313(hutH)
STL: stu1313(hutH)
SSA: SSA_0429(hutH)
SGO: SGO_1811(hutH)
SDS: SDEG_2062(hutH)
CTC: CTC02318
AMT: Amet_3149
AOE: Clos_1187
STH: STH3194
TTE: TTE0844(hutH)
TEX: Teth514_2170
TPD: Teth39_1488
CPO: COPRO5265_0906
NTH: Nther_2820
MSM: MSMEG_1183(hutH)
CAR: cauri_1023(hutH)
NFA: nfa12280(hutH)
RHA: RHA1_ro02154(hutH) RHA1_ro02588
RER: RER_51300(hutH)
ROP: ROP_18710(hutH) ROP_23130
SCO: SCO4932(hutH)
SMA: SAV_3325(hutH) SAV_3504(hutH2)
SGR: SGR_2611(hutH)
LXX: Lxx22140(hutH)
ART: Arth_0375 Arth_3856
AAU: AAur_0399(hutH) AAur_3659(hutH)
ACH: Achl_0589
RSA: RSal33209_1321
KRH: KRH_22980(hutH)
MLU: Mlut_02290
BCV: Bcav_1837
BFA: Bfae_30680
KSE: Ksed_04180
PAC: PPA2170(hutH)
NCA: Noca_4398
TCU: Tcur_3619
SRO: Sros_6152 Sros_7919
NML: Namu_0908 Namu_1421
KRA: Krad_1289 Krad_4453
SEN: SACE_4848(hutH2) SACE_6407(hutH)
AMI: Amir_6266
STP: Strop_1106
SAQ: Sare_0996 Sare_2092
CAI: Caci_0254
BLO: BL1249(hutH)
BLJ: BLD_1584(hutH)
RXY: Rxyl_0576 Rxyl_0581
AFO: Afer_0796
TDE: TDE0588(hutH)
LBI: LEPBI_I0730(hutH)
LBF: LBF_0707(hutH)
ABA: Acid345_1410
ACA: ACP_3026(hutH)
SUS: Acid_5210
BTH: BT_2690
BFR: BF4144
BFS: BF3966(hutH)
BVU: BVU_0338 BVU_1010
PGI: PG0324(hutH)
PGN: PGN_1638
PDI: BDI_3648
SRU: SRU_0722(hutH)
RMR: Rmar_1594
CHU: CHU_2124(hutH)
DFE: Dfer_1999
CPI: Cpin_1853 Cpin_2006
PHE: Phep_1335
GFO: GFO_1500(hutH) GFO_1668(hutH)
FJO: Fjoh_1109 Fjoh_2576
FPS: FP0838(hutH1) FP2287(hutH2)
FBA: FIC_00427
COC: Coch_0449 Coch_1047
RBI: RB2501_04105
FSU: Fisuc_3006
FNU: FN0791(hutH) FN1406(hutH)
GAU: GAU_1937(hutH)
TAI: Taci_0191 Taci_0916
GVI: glr3066
CAU: Caur_0974
CAG: Cagg_1658
CHL: Chy400_1064
HAU: Haur_4629
STI: Sthe_1108
DRA: DR_A0147(hutH)
DGE: Dgeo_2730
DDR: Deide_15220(hutH)
TLE: Tlet_0527
TME: Tmel_1777
TAF: THA_91(hutH)
FNO: Fnod_0129
PMO: Pmob_0239
KOL: Kole_0127
HAL: VNG1212Gm(hutH)
HSL: OE2739F(hutH)
HMA: rrnAC1791(hutH)
TAC: Ta0242(hutH)
TVO: TVN1353(hutH)
PTO: PTO0107(hutH)
PAS: Pars_1482
CMA: Cmaq_1544
 |
|---|
| Structures |
PDB: 1B8F 1EB4 1GK2 1GK3 1GKJ 1GKM 2NYN 3CZO |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13061415]
MEHLER AH, TABOR H.
Deamination of histidine to form urocanic acid in liver.
J. Biol. Chem. 201 (1953) 775-84.
Cavia porcellus, Pseudomonas fluorescens |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:17185227]
Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C.
Discovery of a substrate selectivity switch in tyrosine
ammonia-lyase, a member of the aromatic amino acid lyase family.
Chem. Biol. 13 (2006) 1317-26.
Rhodobacter sphaeroides [GN:rsp], Pseudomonas putida |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:15906398]
Poppe L, Retey J.
Friedel-Crafts-type mechanism for the enzymatic elimination of
ammonia from histidine and phenylalanine.
Angew. Chem. Int. Ed. Engl. 44 (2005) 3668-88.
Rhodobacter capsulatus |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:17185228]
Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP.
Structural determinants and modulation of substrate specificity in
phenylalanine-tyrosine ammonia-lyases.
Chem. Biol. 13 (2006) 1327-38.
Rhodobacter sphaeroides |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:10220322]
Schwede TF, Retey J, Schulz GE.
Crystal structure of histidine ammonia-lyase revealing a novel
polypeptide modification as the catalytic electrophile.
Biochemistry. 38 (1999) 5355-61.
Pseudomonas putida |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.3.1.3
IUBMB Enzyme Nomenclature: 4.3.1.3
ExPASy - ENZYME nomenclature database: 4.3.1.3
BRENDA, the Enzyme Database: 4.3.1.3
CAS: 9013-75-6 |
|---|
