| Entry |
|
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| Name |
formimidoyltetrahydrofolate cyclodeaminase;
formiminotetrahydrofolate cyclodeaminase;
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
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| Class |
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
 |
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| Sysname |
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
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| Reaction(IUBMB) |
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 [RN: R02302]
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| Reaction(KEGG) |
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| Substrate |
5-formimidoyltetrahydrofolate [CPD: C00664]
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| Product |
5,10-methenyltetrahydrofolate [CPD: C00445];
NH3 [CPD: C00014]
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| Comment |
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
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| Pathway |
| One carbon pool by folate | | Metabolic pathways |
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| Orthology |
| formiminotetrahydrofolate cyclodeaminase | | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | NVE: | | AQU: | | DDI: | | DPP: | | DPS: | | DAT: | | DTO: | | SPY: | | SPZ: | | SPM: | | SPG: | | SPS: | | SPH: | | SPI: | | SPJ: | | SPK: | | SPF: | | SPA: | | SPB: | | SOZ: | | SSA: | | SGO: | | SDS: | | CTC: | | AMT: | | OVA: | | TEP: | | TOC: | | ABA: | | SUS: | | OSP: | | PMZ: | | PDN: | | PIT: | | AFD: | | ASH: | | HHY: | | SGN: | | FLI: | | OHO: | | FNU: | | GAU: | | IAL: | | HAU: | | ATM: | | NDE: | | TTR: | | HMA: | | TVO: | | PTO: | | ABI: | | ACF: | |
» show all
 |
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| Reference |
1 |
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| Authors |
Rabinowitz, J.C. and Pricer, W.E. |
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| Title |
Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid. |
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| Journal |
J. Am. Chem. Soc. 78 (1956) 5702-5704. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9032-05-7 |
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