KEGG   ENZYME: 4.3.1.4Help
Entry
EC 4.3.1.4                  Enzyme                                 

Name
formimidoyltetrahydrofolate cyclodeaminase;
formiminotetrahydrofolate cyclodeaminase;
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
Reaction(IUBMB)
5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3 [RN:R02302]
Reaction(KEGG)
Substrate
5-formimidoyltetrahydrofolate [CPD:C00664]
Product
5,10-methenyltetrahydrofolate [CPD:C00445];
NH3 [CPD:C00014]
Comment
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
History
EC 4.3.1.4 created 1961, modified 2000
Pathway
One carbon pool by folate
Metabolic pathways
Orthology
K01746  
formiminotetrahydrofolate cyclodeaminase
K13990  
glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase
Genes
HSA: 
10841(FTCD)
PTR: 
474057(FTCD)
PPS: 
100977170(FTCD)
GGO: 
101130780(FTCD)
PON: 
MCF: 
102134897(FTCD)
MMU: 
14317(Ftcd)
RNO: 
89833(Ftcd)
CGE: 
100754097(Ftcd)
HGL: 
101712457(Ftcd)
TUP: 
102471947(FTCD)
CFA: 
607685(FTCD)
AML: 
FCA: 
101080907(FTCD)
PTG: 
102962298(FTCD)
BTA: 
535816(FTCD)
BOM: 
102278178(FTCD)
PHD: 
102342678(FTCD)
CHX: 
102175530(FTCD)
SSC: 
397517(FTCD)
CFR: 
102517308(FTCD)
BACU: 
103009100(FTCD)
LVE: 
103077712(FTCD)
ECB: 
100049972(FTCD)
MYB: 
102245572(FTCD)
MYD: 
102761291(FTCD)
MDO: 
100026368(FTCD)
SHR: 
100933669(FTCD)
OAA: 
100083636(FTCD)
GGA: 
395726(FTCD)
MGP: 
TGU: 
100221117(FTCD)
FAB: 
101820680(FTCD)
PHI: 
APLA: 
101789783(FTCD)
FPG: 
101910482(FTCD)
FCH: 
102051629(FTCD)
CLV: 
102087672(FTCD)
ASN: 
102375778(FTCD)
AMJ: 
102567824(FTCD)
PSS: 
102463032(FTCD)
CMY: 
102945805(FTCD)
ACS: 
PBI: 
103060660(FTCD)
XLA: 
379483(ftcd)
XTR: 
448617(ftcd)
DRE: 
394052(ftcd)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362862(FTCD)
CMK: 
103188928(ftcd)
BFO: 
CIN: 
SPU: 
NVE: 
AQU: 
DDI: 
DPP: 
DFA: 
DPS: 
DAT: 
HRM2_43160(ftcD1) HRM2_44060(ftcD2)
DTO: 
SPY: 
SPZ: 
SPM: 
SPG: 
SPS: 
SPH: 
SPI: 
SPJ: 
SPK: 
SPF: 
SPA: 
SPB: 
SOZ: 
SSA: 
SGO: 
SDS: 
CTC: 
AMT: 
OVA: 
TEP: 
TOC: 
ABA: 
SUS: 
FNU: 
GAU: 
GBA: 
BACC: 
OSP: 
PMZ: 
PDN: 
PIT: 
AFD: 
ASH: 
DOI: 
HHY: 
SGN: 
FLI: 
OHO: 
IAL: 
MRO: 
HAU: 
ATM: 
NDE: 
TTR: 
HMA: 
pNG7381(ftc)
PTO: 
ABI: 
ACF: 
 » show all
Taxonomy
Reference
1
  Authors
Rabinowitz, J.C. and Pricer, W.E.
  Title
Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid.
  Journal
J. Am. Chem. Soc. 78 (1956) 5702-5704.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-05-7

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