KEGG   ENZYME: 4.3.2.5Help
Entry
EC 4.3.2.5                  Enzyme                                 

Name
peptidylamidoglycolate lyase;
alpha-hydroxyglycine amidating dealkylase;
peptidyl-alpha-hydroxyglycine alpha-amidating lyase;
HGAD;
PGL;
PAL;
peptidylamidoglycolate peptidylamide-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
peptidylamidoglycolate peptidyl-amide-lyase (glyoxylate-forming)
Reaction(IUBMB)
peptidylamidoglycolate = peptidyl amide + glyoxylate [RN:R03874]
Reaction(KEGG)
Substrate
peptidylamidoglycolate [CPD:C03303]
Product
peptidyl amide [CPD:C02179];
glyoxylate [CPD:C00048]
Comment
The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide.
History
EC 4.3.2.5 created 1992
Orthology
K18200  
peptidylamidoglycolate lyase
Genes
HSA: 
5066(PAM)
PTR: 
461974(PAM)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
707733(PAM)
MCF: 
CJC: 
MMU: 
18484(Pam)
RNO: 
25508(Pam)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
479145(PAM)
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
280890(PAM)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
791244(PAM)
MYB: 
MYD: 
PALE: 
MDO: 
OAA: 
GGA: 
427274(PAM)
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379207(pam-a) 397736(pam-b)
XTR: 
DRE: 
570822(pam)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_T19B4.1(pamn-1)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
TAD: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:2207061]
  Authors
Katopodis AG, Ping D, May SW.
  Title
A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of alpha-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine alpha-amidating monooxygenase in peptide amidation.
  Journal
Biochemistry. 29 (1990) 6115-20.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
131689-50-4

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