| Entry |
|
|---|
| Name |
strictosidine synthase;
strictosidine synthetase;
STR;
3-alpha(S)-strictosidine tryptamine-lyase |
|---|
| Class |
Lyases;
Carbon-nitrogen lyases;
Amine-lyases
 |
|---|
| Sysname |
3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming) |
|---|
| Reaction(IUBMB) |
3-alpha(S)-strictosidine + H2O = tryptamine + secologanin
[RN:R03738] |
|---|
| Reaction(KEGG) |
R03738
 |
|---|
| Substrate |
3-alpha(S)-strictosidine [CPD:C03470];
H2O [CPD:C00001] |
|---|
| Product |
tryptamine [CPD:C00398];
secologanin [CPD:C01852] |
|---|
| Comment |
Catalyses a Pictet-Spengler reaction between the aldehyde group of
secologanin and the amino group of tryptamine [4,5]. Involved in the
biosynthesis of the monoterpenoid indole alkaloids. |
|---|
| Pathway |
PATH: ec00901 Indole alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01757 strictosidine synthase |
|---|
| Genes |
DME: Dmel_CG11833(Ssl2)
ATH: AT1G74000(SS3) AT1G74010 AT1G74020(SS2)
RHA: RHA1_ro00912
LIL: LA4215
LIC: LIC13366
 |
|---|
| Structures |
PDB: 2FP8 2FP9 2FPB 2FPC 2V91 2VAQ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:510306]
Treimer JF, Zenk MH.
Purification and properties of strictosidine synthase, the key
enzyme in indole alkaloid formation.
Eur. J. Biochem. 101 (1979) 225-33.
Catharanthus roseus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7763429]
Kutchan TM.
Strictosidine: from alkaloid to enzyme to gene.
Phytochemistry. 32 (1993) 493-506.
Catharanthus roseus, Rauvolfia serpentina |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:7887913]
de Waal A, Meijer AH, Verpoorte R.
Strictosidine synthase from Catharanthus roseus: purification and
characterization of multiple forms.
Biochem. J. 306 ( Pt 2) (1995) 571-80.
Catharanthus roseus |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:16133216]
Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stockigt J.
Functional expression of an ajmaline pathway-specific esterase from
Rauvolfia in a novel plant-virus expression system.
Planta. 222 (2005) 888-98.
Rauvolfia serpentina |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:16481164]
McCoy E, Galan MC, O'Connor SE.
Substrate specificity of strictosidine synthase.
Bioorg. Med. Chem. Lett. 16 (2006) 2475-8.
Catharanthus roseus |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:16531499]
Ma X, Panjikar S, Koepke J, Loris E, Stockigt J.
The structure of Rauvolfia serpentina strictosidine synthase is a
novel six-bladed beta-propeller fold in plant proteins.
Plant. Cell. 18 (2006) 907-20.
Rauvolfia serpentina |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.3.3.2
IUBMB Enzyme Nomenclature: 4.3.3.2
ExPASy - ENZYME nomenclature database: 4.3.3.2
BRENDA, the Enzyme Database: 4.3.3.2
CAS: 69669-72-3 |
|---|
