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Entry
EC 4.4.1.11                 Enzyme                                 
Name methionine gamma-lyase;
L-methioninase;
methionine lyase;
methioninase;
methionine dethiomethylase;
L-methionine gamma-lyase;
L-methionine methanethiol-lyase (deaminating)
Class Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname L-methionine methanethiol-lyase (deaminating;
2-oxobutanoate-forming)
Reaction(IUBMB) (1) L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
(overall reaction) [RN:R00654];
(2) (1a) L-methionine = methanethiol + 2-ammoniobut-2-enoate
[RN:R08635];
(3) (1b) 2-ammoniobut-2-enoate + H2O = 2-oxobutanoate + NH3
(spontaneous) [RN:R08637]
Reaction(KEGG) R00654 R08635 R08637;
(other) R04770
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Substrate L-methionine [CPD:C00073];
H2O [CPD:C00001];
2-ammoniobut-2-enoate [CPD:C17234]
Product methanethiol [CPD:C00409];
NH3 [CPD:C00014];
2-oxobutanoate [CPD:C00109];
2-ammoniobut-2-enoate [CPD:C17234]
Cofactor Pyridoxal phosphate [CPD:C00018]
Comment A pyridoxal-phosphate protein.
Pathway PATH: ec00270  Cysteine and methionine metabolism
PATH: ec00450  Selenoamino acid metabolism
Orthology KO: K01761  methionine-gamma-lyase
Genes CBR: CBG22025
ATH: AT1G64660(ATMGL)
POP: POPTR_709036
RCU: RCOM_1313240
VVI: 100253026(GSVIVT00000520001)
OSA: 4349123(Os10g0517500)
SBI: SORBI_01g017060(SORBIDRAFT_01g017060)
ZMA: 100285862
PPP: PHYPADRAFT_201470 PHYPADRAFT_207198
TVA: TVAG_147790
EFE: EFER_3533
ETA: ETA_08500(mdeA)
CKO: CKO_04984
SPE: Spro_0798
PMR: PMI1248 PMI2254(mdeA)
PPU: PP_1308(mdeA)
PPF: Pput_4416
PPG: PputGB1_4541
PPW: PputW619_0915
PFL: PFL_3514(megL)
PFS: PFLU2558
PEN: PSEEN4515(mdeA)
SON: SO_1812(mdeA)
SDN: Sden_2521
SFR: Sfri_1369
SAZ: Sama_1242
SBL: Sbal_0312 Sbal_1622
SBM: Shew185_1611
SBN: Sbal195_0316 Sbal195_1645
SBP: Sbal223_0317 Sbal223_2732
SLO: Shew_2491
SPC: Sputcn32_0729 Sputcn32_1507
SSE: Ssed_1559
SPL: Spea_2664
SHE: Shewmr4_2477
SHM: Shewmr7_2545
SHN: Shewana3_2643
SHW: Sputw3181_2594 Sputw3181_3444
SHL: Shal_2751
SWD: Swoo_3095
SWP: swp_3243
ILO: IL0726
CPS: CPS_1705(megL)
PHA: PSHAa2044(mdeA)
AHA: AHA_1947
ASA: ASA_2347(mdeA)
KKO: Kkor_1449
BMA: BMAA1317
BMV: BMASAVP1_0300
BML: BMA10229_0575
BMN: BMA10247_A0992
BPS: BPSS0913
BPL: BURPS1106A_A1255
BPD: BURPS668_A1327
BUR: Bcep18194_B2807
BPH: Bphy_5613
BGL: bglu_2g19560
RFR: Rfer_3649 Rfer_4139
APP: CAP2UW1_0185
DAT: HRM2_06160(mdeA)
AFW: Anae109_4085
HOH: Hoch_5099
MLO: mll1618
SME: SMc01666(mdeA)
SMD: Smed_2201
ATU: Atu3806(mdeA)
ATC: AGR_L_2052
RET: RHE_PF00019(mdeAf)
REC: RHECIAT_PC0000024(mdeAc)
RLE: pRL120373
RLT: Rleg2_4673 Rleg2_5066
RLG: Rleg_4740
RHI: NGR_c21870
BME: BMEI0103
BMF: BAB1_1966
BMB: BruAb1_1941
BMC: BAbS19_I18440
BMS: BR1965
BMT: BSUIS_A1805(mdeA)
BCS: BCAN_A2010(mdeA)
BMR: BMI_I1987
OAN: Oant_1017
BJA: bll5911(mdeA)
RPB: RPB_0450
RPT: Rpal_0375
NHA: Nham_1875
MRD: Mrad2831_3235
MET: M446_0251
MNO: Mnod_5459
CCR: CC_3168
CCS: CCNA_03271
SIL: SPOA0318(megL)
SIT: TM1040_2737
RDE: RD1_2640(mdeA)
HNE: HNE_3448(mdeA)
ZMO: ZMO0676
NAR: Saro_3503
SAL: Sala_0483
SWI: Swit_0856
ELI: ELI_09475
MGM: Mmc1_0771
BHA: BH0799
BAN: BA4906(megL)
BAR: GBAA4906(megL)
BAA: BA_5327
BAT: BAS4553
BAH: BAMEG_4939(megL)
BAI: BAA_4918(megL)
BCE: BC4654
BCA: BCE_4791(megL)
BCZ: BCZK4398(megL)
BCR: BCAH187_A4789(megL)
BCB: BCB4264_A4763(megL)
BCU: BCAH820_4772(megL)
BCG: BCG9842_B0472(megL)
BCQ: BCQ_4470(megL)
BCX: BCA_4769(megL)
BCY: Bcer98_3326
BTK: BT9727_4388(megL)
BTL: BALH_4232(megL)
BWE: BcerKBAB4_4484
BCL: ABC3938
OIH: OB3046
BBE: BBR47_55420(megL)
CTC: CTC02530
CNO: NT01CX_0149(megL)
CDF: CD3577(mdeA)
CDC: CD196_3369(mdeA)
CDL: CDR20291_3415(mdeA)
CBO: CBO0029(mdeA)
CBA: CLB_0039(megL)
CBH: CLC_0047(megL)
CBY: CLM_0033(megL)
CBL: CLK_3163(megL)
CBB: CLD_0789(megL)
CBI: CLJ_B0032(megL)
CBF: CLI_0043(megL)
CKR: CKR_1517
STH: STH832
TEX: Teth514_1860
TPD: Teth39_0884 Teth39_0897
CPO: COPRO5265_1318
NTH: Nther_2455 Nther_2677
HOR: Hore_08000
ROP: ROP_72220
GBR: Gbro_1986
SMA: SAV_7062(mgl)
SGR: SGR_6256
RSA: RSal33209_3167
KSE: Ksed_24950
TCU: Tcur_3821
SRO: Sros_2587
SEN: SACE_3377(megL)
SVI: Svir_19090
CAI: Caci_5539
SHI: Shel_27220
TDE: TDE2200(megL)
PGI: PG0343(megL)
PGN: PGN_1618
RMR: Rmar_1177
GFO: GFO_2175(mdeA)
FJO: Fjoh_2131
FPS: FP1733
RBI: RB2501_14304
FNU: FN1419
GAU: GAU_2561
RRS: RoseRS_4038
RCA: Rcas_3672
CAU: Caur_3273
CAG: Cagg_0621
CHL: Chy400_3533
TRO: trd_0392
STI: Sthe_0034
DRA: DR_0921
DGE: Dgeo_0011
DDR: Deide_21530
TLE: Tlet_1106
KOL: Kole_0404
TTR: Tter_2737
MAC: MA2532(mgl)
MBA: Mbar_A3023
MMA: MM_3085
MBN: Mboo_1995
MPL: Mpal_0648
Taxonomy
Structures PDB: 1E5E  1E5F  1GC0  1GC2  1PFF  1PG8  1UKJ  1Y4I  2O7C  2RFV  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:4720797]
Kreis W, Hession C.
Isolation and purification of
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
(L-methioninase) from Clostridium sporogenes.
Cancer. Res. 33 (1973) 1862-5.
Clostridium sporogenes
Other DBs ExplorEnz - The Enzyme Database: 4.4.1.11
IUBMB Enzyme Nomenclature: 4.4.1.11
ExPASy - ENZYME nomenclature database: 4.4.1.11
UM-BBD (Biocatalysis/Biodegradation Database): 4.4.1.11
BRENDA, the Enzyme Database: 4.4.1.11
CAS: 42616-25-1
DBGET integrated database retrieval system