KEGG ENZYME: 4.4.1.15

KEGG

ENZYME: 4.4.1.15

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Entry

EC 4.4.1.15 Enzyme

Name

D-cysteine desulfhydrase;
D-cysteine lyase;
D-cysteine sulfide-lyase (deaminating)

Class

Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)

BRITE hierarchy

Sysname

D-cysteine sulfide-lyase (deaminating; pyruvate-forming)

Reaction(IUBMB)

D-cysteine + H2O = sulfide + NH3 + pyruvate [RN:R01874]

Reaction(KEGG)

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Substrate

D-cysteine [CPD:C00793];
H2O [CPD:C00001]

Product

sulfide [CPD:C00283];
NH3 [CPD:C00014];
pyruvate [CPD:C00022]

Pathway

Cysteine and methionine metabolism

Orthology

D-cysteine desulfhydrase

Genes

ECO:	b1919(dcyD)
ECJ:	Y75_p1890(yedO)
ECD:	ECDH10B_2060(dcyD)
EBW:	BWG_1728(dcyD)
ECE:	Z3008(yedO)
ECF:	ECH74115_2693(dcyD)
ETW:	ECSP_2523(dcyD)
ELX:	CDCO157_2456A
EOJ:	ECO26_2811(dcyD)
EOI:	ECO111_2499(dcyD)
EOH:	ECO103_2175(dcyD)
ECG:	E2348C_2037(dcyD)
EOK:	G2583_2370(dcyD)
ELR:	ECO55CA74_11400
ECC:	c2333(yedO)
ECI:	UTI89_C2120
ECV:	APECO1_960(yedO)
ECX:	EcHS_A2018(dcyD)
ECW:	EcE24377A_2153(dcyD)
ECM:	EcSMS35_1263(dcyD)
ECY:	ECSE_2150
ECR:	ECIAI1_2004(yedO)
ECQ:	ECED1_2184(yedO)
ECK:	EC55989_2140(yedO)
ECT:	ECIAI39_1136(yedO)
EOC:	CE10_2204(dcyD)
EUM:	ECUMN_2211(yedO)
ECZ:	ECS88_1973(yedO)
ELO:	EC042_2080(dcyD)
ELN:	NRG857_09585
ELH:	ETEC_2027
ESE:	ECSF_1771
ESO:	O3O_15595
ESM:	O3M_09995
ESL:	O3K_10035
ECL:	EcolC_1720
EBD:	ECBD_1723
EKO:	EKO11_1855
EKF:	KO11_13130(dcyD)
EAB:	ECABU_c21790(dcyD)
EDH:	EcDH1_1727
EDJ:	ECDH1ME8569_1859(yedO)
EIH:	ECOK1_2036(dcyD)
ENA:	ECNA114_2010(yedO)
ELU:	UM146_07585
EUN:	UMNK88_2394
ELW:	ECW_m2093(dcyD)
ELL:	WFL_10255(dcyD)
ELC:	i14_2149(yedO)
ELD:	i02_2149(yedO)
ELP:	P12B_c1146(yedO)
ELF:	LF82_0454(dcyD)
ECOA:	APECO78_13380
EFE:	EFER_1175(yedO)
EBT:	EBL_c15470(dcyD)
STY:	STY2161
STT:	t0923
SEX:	STBHUCCB_9940
STM:	STM1953(yedO)
SEO:	STM14_2371(yedO)
SEV:	STMMW_19321
SEY:	SL1344_1882(dcyD)
SEM:	STMDT12_C19740
SEJ:	STMUK_1932(yedO)
SEB:	STM474_1984(yedO)
SEF:	UMN798_2060(dcyD)
SPT:	SPA0916(yedO)
SEK:	SSPA0854
SPQ:	SPAB_01203
SEI:	SPC_1761(yedO)
SEC:	SC1957(yedO)
SEH:	SeHA_C2168
SHB:	SU5_02557
SEE:	SNSL254_A2115
SEW:	SeSA_A2109
SEA:	SeAg_B1167
SED:	SeD_A1290
SEG:	SG1101(yedO)
SEL:	SPUL_1841(yedO)
SET:	SEN1054(yedO)
SENJ:	CFSAN001992_01685
SES:	SARI_00984
SBG:	SBG_1783
YPE:	YPO1845(yedO)
YPK:	y2462
YPA:	YPA_1221
YPN:	YPN_2278
YPM:	YP_1548(Acd)
YPP:	YPDSF_1281
YPG:	YpAngola_A2030(dcyD)
YPZ:	YPZ3_1882
YPT:	A1122_16640
YPD:	YPD4_1636
YPX:	YPD8_1917
YPH:	YPC_2419(dcyD)
YPS:	YPTB1717(YedO)
YPI:	YpsIP31758_2275(dcyD)
YPY:	YPK_2377
YPB:	YPTS_1846
YEN:	YE2517(YedO)
YEP:	YE105_C1738
YEY:	Y11_13971
SFL:	SF1962(yedO)
SFX:	S2058(yedO)
SFV:	SFV_1963(yedO)
SFE:	SFxv_2191(dcyD)
SSN:	SSON_1199(yedO)
SSJ:	SSON53_06425
SBO:	SBO_1087(yedO)
SBC:	SbBS512_E1047(dcyD)
SDY:	SDY_1098(yedO)
ECA:	ECA1531
PCT:	PC1_1404
PWA:	Pecwa_1802
PEC:	W5S_1716
ETA:	ETA_14280(dcyD)
EBI:	EbC_26330
SGL:	SG0911
ENT:	Ent638_2506
ENC:	ECL_01369(dcyD)
ENO:	ECENHK_14025
ECLO:	ENC_05570
ESC:	Entcl_1822
EEC:	EcWSU1_02860(dcyD)
ENL:	A3UG_14285
EAS:	Entas_2636
EAE:	EAE_23050
EAR:	ST548_p7714
ESA:	ESA_01304
CSK:	ES15_1525(dcyD)
CSZ:	CSSP291_06410
CTU:	CTU_26220(dcyD)
KPN:	KPN_02417(yedO)
KPU:	KP1_3548(yedO)
KPM:	KPHS_34380
KPP:	A79E_1814
KPE:	KPK_1864(dcyD)
KPO:	KPN2242_15050
KVA:	Kvar_1690
KOX:	KOX_18740 KOX_24135
CKO:	CKO_01026 CKO_02077
CRO:	ROD_19741(dcyD)
SPE:	Spro_2937
SRR:	SerAS9_3018
SRS:	SerAS12_3019
SRA:	SerAS13_3021
SMAF:	D781_2708
SMW:	SMWW4_v1c29360(dcyD)
DDA:	Dd703_1185 Dd703_1301
DDD:	Dda3937_02691(dcyD)
XNE:	XNC1_0548
PAM:	PANA_2262(dcyD)
PLF:	PANA5342_1841(dcyD)
PAJ:	PAJ_1574(dcyD)
PAQ:	PAGR_g1776
PVA:	Pvag_1754(yedO)
PAO:	Pat9b_2367 Pat9b_5047
RAH:	Rahaq_2317 Rahaq_2468
RAQ:	Rahaq2_2422 Rahaq2_2528
RAA:	Q7S_11730 Q7S_12485
PSI:	S70_20855
MMK:	MU9_386
EBF:	D782_1710 D782_2775
PPUU:	PputUW4_00193(dcyD)
PST:	PSPTO_5179
PSB:	Psyr_0359
PSP:	PSPPH_0343(dcyD)
PFL:	PFL_0249(dcyD)
PFO:	Pfl01_0245
PFS:	PFLU0247(dcyD)
PFE:	PSF113_0270(dcyD)
PFC:	PflA506_0248(dcyD)
PPZ:	H045_22150
PMY:	Pmen_2010
PSA:	PST_2349
PSZ:	PSTAB_2229
PSR:	PSTAA_2376
PSJ:	PSJM300_07485
PBA:	PSEBR_a269
PFV:	Psefu_2413
PDR:	H681_18065
PAR:	Psyc_1604
PCR:	Pcryo_1828
ACI:	ACIAD0753
ACD:	AOLE_12720
ACB:	A1S_0773
ABM:	ABSDF2692
ABY:	ABAYE3037
SPL:	Spea_4164
SHL:	Shal_0079
PAT:	Patl_1784 Patl_2666
SDE:	Sde_1663
GAG:	Glaag_1613 Glaag_1767
GPS:	C427_0873 C427_3081
TTU:	TERTU_1738
LLO:	LLO_1453
SAGA:	M5M_03580
REU:	Reut_B3582
CNC:	CNE_1c19560(dcyD)
BMA:	BMA2137(dcyD)
BMV:	BMASAVP1_A0774(dcyD)
BML:	BMA10229_A2607(dcyD)
BMN:	BMA10247_2006(dcyD)
BPS:	BPSL2618
BPM:	BURPS1710b_3094(dcyD)
BPL:	BURPS1106A_3059(dcyD) BURPS1106A_A1590
BPD:	BURPS668_3006(dcyD)
BPR:	GBP346_A3196
BPZ:	BP1026B_I0702 BP1026B_II1260
BPQ:	BPC006_I3100 BPC006_II1587
BTE:	BTH_II1216
BUR:	Bcep18194_C6869
BPH:	Bphy_5685
BGE:	BC1002_4820
BGD:	bgla_2g09270
BPA:	BPP4074
BPAR:	BN117_4146
BBR:	BB4545
BBM:	BN115_4222
BBH:	BN112_3877
PUT:	PT7_2783
POL:	Bpro_2169
RTA:	Rta_18290 Rta_27290(dcyD)
DVU:	DVU2646
DVL:	Dvul_0604
DVG:	Deval_2444
DDE:	Dde_2581
DDS:	Ddes_0339
DSA:	Desal_1391
DPS:	DP1505 DP1509
DAL:	Dalk_2543
DAT:	HRM2_15340(dcyD1) HRM2_15620(dcyD2)
ADE:	Adeh_1432
ACP:	A2cp1_2515
AFW:	Anae109_2397
ANK:	AnaeK_2428
SCL:	sce4395 sce6080(yedO)
HOH:	Hoch_5266
SFU:	Sfum_1836
DBR:	Deba_0147
PLA:	Plav_0934
SMD:	Smed_5532
REC:	RHECIAT_PC0000806
RLG:	Rleg_6848
RPE:	RPE_2871
XAU:	Xaut_4875 Xaut_5055
MEX:	Mext_2357
MEA:	Mex_1p2360(dcyD)
MDI:	METDI3140(dcyD)
MCH:	Mchl_2636
MPO:	Mpop_2314
CCR:	CC_2032
CCS:	CCNA_02112
CAK:	Caul_3180
CSE:	Cseg_1395
PZU:	PHZ_c2912
BSB:	Bresu_3207
SIL:	SPO2657 SPOA0158(cuyA)
JAN:	Jann_2876
RDE:	RD1_0819 RD1_1838
RLI:	RLO149_c007450(cuyA)
DSH:	Dshi_1439
PGA:	PGA1_c25520(dcyD) PGA1_c33720(dcyD2)
ZMP:	Zymop_1074
APB:	SAR116_2240
BAN:	BA_3236
BAR:	GBAA_3236
BAT:	BAS3005
BAH:	BAMEG_1379
BAI:	BAA_3282
BAX:	H9401_3084
BAL:	BACI_c31780
BCE:	BC3216
BCA:	BCE_3261
BCZ:	BCZK2930
BCR:	BCAH187_A3263
BCB:	BCB4264_A3235
BCU:	BCAH820_3241
BCG:	BCG9842_B2011
BCQ:	BCQ_3043
BCX:	BCA_3263
BNC:	BCN_3060
BCF:	bcf_15745
BCER:	BCK_18905
BTK:	BT9727_2992
BTL:	BALH_2878
BTB:	BMB171_C2902
BTT:	HD73_2778
BTC:	CT43_CH3170
BTF:	YBT020_15975
BTM:	MC28_2363
BTG:	BTB_c33040(dcyD)
BTI:	BTG_03295
BTN:	BTF1_13540
BTHT:	H175_ch3225
BWE:	BcerKBAB4_2951
BMQ:	BMQ_3912
BMD:	BMD_3902
BMH:	BMWSH_1313
BCO:	Bcell_1078
SSP:	SSP0338
BBE:	BBR47_46970
CKL:	CKL_0509
CKR:	CKR_0446
CSH:	Closa_1802 Closa_3827
CST:	CLOST_1978
AMT:	Amet_0592
DDH:	Desde_0554
DDL:	Desdi_0199
DRM:	Dred_0406 Dred_0413
DRU:	Desru_1185
SGY:	Sgly_0958
DOR:	Desor_0514
DMI:	Desmer_0610
BPB:	bpr_I2541
OVA:	OBV_06350
NTH:	Nther_0310
MED:	MELS_0576
MSA:	Mycsm_01872
MMI:	MMAR_2945
MRH:	MycrhN_2906
MCB:	Mycch_5449 Mycch_5963
MLI:	MULP_02887
RER:	RER_54610
REQ:	REQ_07970
SMA:	SAV_1520
SVL:	Strvi_4207
SHY:	SHJG_8020
SHO:	SHJGH_7782
CMS:	CMS_2096
NCA:	Noca_4819 Noca_4836
MMAR:	MODMU_3995
KRA:	Krad_0767
AMD:	AMED_0412(dcyD)
AMN:	RAM_02115
AMM:	AMES_0412(dcyD)
PDX:	Psed_1622
CWO:	Cwoe_4024
AYM:	YM304_36460
PDI:	BDI_0430
AAS:	Aasi_0858
FSU:	Fisuc_2650
FSC:	FSU_3220
ACO:	Amico_1766
TLI:	Tlie_1698
AMR:	AM1_1636
IAL:	IALB_2042(dcyD)
TRO:	trd_1612
STI:	Sthe_0126
ATM:	ANT_22590
DDR:	Deide_3p00380(dcyD)
DMR:	Deima_0374
TMA:	TM0225
TPT:	Tpet_0699
TLE:	Tlet_0557
TRQ:	TRQ2_0723
TNA:	CTN_0461
TNP:	Tnap_0855
TTA:	Theth_0760
MPG:	Theba_2461
PFI:	PFC_08160
PYS:	Py04_0127

Taxonomy

Reference

1 [PMID:3908101]

Authors

Nagasawa T, Ishii T, Kumagai H, Yamada H.

Title

D-Cysteine desulfhydrase of Escherichia coli. Purification and characterization.

Journal

Eur. J. Biochem. 153 (1985) 541-51.

Organism

Escherichia coli [GN:eco]

Reference

2

Authors

Schmidt, A.

Title

A cysteine desulfhydrase from spinach leaves specific for D-cysteine.

Journal

Z. Pflanzenphysiol. 107 (1982) 301-312.

Reference

3

Authors

Schmidt, A. and Erdle, I.

Title

A cysteine desulfhydrase specific for D-cysteine from the green-alga Chlorella fusca.

Journal

Z. Naturforsch. C: Biosci. 38 (1983) 428-435.

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:

84012-74-8

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (6)   
   KEGG REACTION (1)   
   KEGG RPAIR (4)   
   KEGG RCLASS (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (1798)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (388)   
   KEGG DGENES (1)   
   KEGG EGENES (9)   
   KEGG MGENES (1399)   
Protein sequence (2242)   
   UniProt (1211)   
   PRF (8)   
   RefSeq(pep) (975)   
   PDBSTR (48)   
DNA sequence (1271)   
   RefSeq(nuc) (969)   
   GenBank (152)   
   EMBL (150)   
3D Structure (11)   
   PDB (11)   
Protein domain (2)   
   InterPro (2)   
Literature (1)   
   PubMed (1)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (5346)   

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