| Entry |
|
|---|
| Name |
homocysteine desulfhydrase;
homocysteine desulfurase, L-homocysteine hydrogen-sulfide-lyase
(deaminating) |
|---|
| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
L-homocysteine hydrogen-sulfide-lyase (deaminating;
2-oxobutanoate-forming) |
|---|
| Reaction(IUBMB) |
(1) L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate
(overall reaction) [RN:R01283];
(2) (1a) L-homocysteine = hydrogen sulfide + 2-ammoniobut-2-enoate
[RN:R08633];
(3) (1b) 2-ammoniobut-2-enoate + H2O = 2-oxobutanoate + NH3
(spontaneous) [RN:R08637] |
|---|
| Reaction(KEGG) |
R01283 R08633 R08637
 |
|---|
| Substrate |
L-homocysteine [CPD:C00155];
H2O [CPD:C00001];
2-ammoniobut-2-enoate [CPD:C17234] |
|---|
| Product |
hydrogen sulfide [CPD:C00283];
NH3 [CPD:C00014];
2-oxobutanoate [CPD:C00109];
2-ammoniobut-2-enoate [CPD:C17234] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018] |
|---|
| Comment |
A pyridoxal-phosphate protein. |
|---|
| Pathway |
PATH: ec00910 Nitrogen metabolism
PATH: ec00920 Sulfur metabolism |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14917685]
KALLIO RE.
Function of pyridoxal phosphate in desulfhydrase systems of Proteus
morganii.
J. Biol. Chem. 192 (1951) 371-7.
Proteus morganii |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.4.1.2
IUBMB Enzyme Nomenclature: 4.4.1.2
ExPASy - ENZYME nomenclature database: 4.4.1.2
BRENDA, the Enzyme Database: 4.4.1.2
CAS: 9024-41-3 |
|---|
