KEGG   ENZYME: 4.4.1.20Help
Entry
EC 4.4.1.20                 Enzyme                                 

Name
leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
Reaction(IUBMB)
leukotriene C4 = leukotriene A4 + glutathione [RN:R03059]
Reaction(KEGG)
Substrate
leukotriene C4 [CPD:C02166]
Product
leukotriene A4 [CPD:C00909];
glutathione [CPD:C00051]
Comment
The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.
History
EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K00807  
leukotriene-C4 synthase
Genes
HSA: 
4056(LTC4S)
PTR: 
739986(LTC4S)
PPS: 
100983593(LTC4S)
GGO: 
101148178(LTC4S)
PON: 
100456952(LTC4S)
MCC: 
705233(LTC4S)
MCF: 
102141868(LTC4S)
MMU: 
17001(Ltc4s)
RNO: 
114097(Ltc4s)
HGL: 
101722474(Ltc4s)
CFA: 
607316(LTC4S)
FCA: 
101096198(LTC4S)
PTG: 
102964525(LTC4S)
BTA: 
511749(LTC4S)
BOM: 
102278603(LTC4S)
SSC: 
100520063(LTC4S)
BACU: 
103011981(LTC4S)
LVE: 
103085740(LTC4S)
ECB: 
100067282(LTC4S)
PALE: 
102882511(LTC4S)
MDO: 
100032154(LTC4S)
GGA: 
770619 770665(LTC4S)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
PBI: 
103060000(LTC4S)
XLA: 
495166(ltc4s.2)
XTR: 
100127769(mgst2)
DRE: 
100535432(ltc4s)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103188230(ltc4s)
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:6324687]
  Authors
Bach MK, Brashler JR, Morton DR Jr.
  Title
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
  Journal
Arch. Biochem. Biophys. 230 (1984) 455-65.
  Organism
Rattus norvegicus
Reference
2  [PMID:2846379]
  Authors
Shimizu T.
  Title
Enzymes functional in the syntheses of leukotrienes and related compounds.
  Journal
Int. J. Biochem. 20 (1988) 661-6.
Reference
3  [PMID:12432940]
  Authors
Lam BK, Austen KF.
  Title
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
  Journal
Prostaglandins. Other. Lipid. Mediat. 68-69 (2002) 511-20.
  Organism
Homo sapiens
Reference
4  [PMID:12023288]
  Authors
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ.
  Title
Membrane localization and topology of leukotriene C4 synthase.
  Journal
J. Biol. Chem. 277 (2002) 28902-8.
  Organism
Mus musculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
90698-32-1

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