| Entry |
|
|---|
| Name |
S-ribosylhomocysteine lyase;
S-ribosylhomocysteinase;
LuxS |
|---|
| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase
[(4S)-4,5-dihydroxypentan-2,3-dione-forming] |
|---|
| Reaction(IUBMB) |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine +
(4S)-4,5-dihydroxypentan-2,3-dione [RN:R01291] |
|---|
| Reaction(KEGG) |
R01291
 |
|---|
| Substrate |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine [CPD:C03539] |
|---|
| Product |
L-homocysteine [CPD:C00155];
(4S)-4,5-dihydroxypentan-2,3-dione [CPD:C11838] |
|---|
| Comment |
Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed
spontaneously cyclizes and combines with borate to form an
autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which
is used by many bacteria to control gene expression in response to
cell density [2]. |
|---|
| Pathway |
PATH: ec00270 Cysteine and methionine metabolism |
|---|
| Orthology |
KO: K07173 S-ribosylhomocysteine lyase |
|---|
| Genes |
ECO: b2687(luxS)
ECJ: JW2662(luxS)
ECD: ECDH10B_2854(luxS)
EBW: BWG_2428(luxS)
ECE: Z3988(ygaG)
ECS: ECs3549
ECF: ECH74115_3932(luxS)
ETW: ECSP_3634(luxS)
ECG: E2348C_2955(luxS)
ECC: c3244(ygaG)
ECI: UTI89_C3049(luxS)
ECP: ECP_2652
ECV: APECO1_3834(luxS)
ECW: EcE24377A_2970(luxS)
ECX: EcHS_A2823(luxS)
ECM: EcSMS35_2809(luxS)
ECY: ECSE_2940
ECL: EcolC_1020
ECK: EC55989_2954(luxS)
ECQ: ECED1_3141(luxS)
ECR: ECIAI1_2782(luxS)
ECT: ECIAI39_2877(luxS)
ECZ: ECS88_2954(luxS)
EUM: ECUMN_3012(luxS)
ELF: LF82_1237(luxS)
EBL: B21_02507(ygaG)
EBD: ECBD_1033
EBR: ECB_02542(ygaG)
EOH: ECO103_3227(luxS)
EOI: ECO111_3410(luxS)
EOJ: ECO26_3755(luxS)
EFE: EFER_0382(luxS)
STY: STY2943(luxS)
STT: t2714(luxS)
SPT: SPA2675(luxS)
SEK: SSPA2494
SPQ: SPAB_03501
SEI: SPC_2863(luxS)
SEC: SC2752(luxS)
SEH: SeHA_C3001(luxS)
SEE: SNSL254_A3018(luxS)
SEW: SeSA_A2966(luxS)
SEA: SeAg_B2935(luxS)
SED: SeD_A3125(luxS)
SEG: SG2725(luxS)
SET: SEN2662(luxS)
SES: SARI_00157
STM: STM2817(luxS)
YPE: YPO3300(luxS)
YPK: y0888
YPM: YP_0386(luxS)
YPA: YPA_2844
YPN: YPN_0794
YPG: YpAngola_A0890(luxS)
YPP: YPDSF_3061
YPS: YPTB0830(luxS)
YPI: YpsIP31758_3233(luxS)
YPY: YPK_3368
YPB: YPTS_0866
YEN: YE0839(luxS)
SFL: SF2714(ygaG)
SFX: S2901(ygaG)
SFV: SFV_2817(ygaG)
SSN: SSON_2831(ygaG)
SBO: SBO_2830(ygaG)
SBC: SbBS512_E3189(luxS)
SDY: SDY_2884(ygaG)
ECA: ECA3362(luxS)
PCT: PC1_3206
PWA: Pecwa_1121
ETA: ETA_26610(luxS)
PLU: plu1253(luxS)
PAY: PAU_03208(luxS)
SGL: SG0542
ENT: Ent638_3167
ESA: ESA_00581
CTU: Ctu_32870(luxS)
KPN: KPN_03018(ygaG)
KPE: KPK_1109(luxS)
KPU: KP1_4284(ygaG)
CKO: CKO_04036
SPE: Spro_0848
PMR: PMI0379(luxS)
EIC: NT01EI_3227
ETR: ETAE_2854(luxS)
DDA: Dd703_1003
DDC: Dd586_3179
DZE: Dd1591_0988
HIN: HI0491(luxS)
HIT: NTHI0621(luxS)
HIP: CGSHiEE_00530
HIQ: CGSHiGG_05710
HDU: HD0370(luxS)
HAP: HAPS_0063(luxS)
HSO: HS_0550(luxS)
HSM: HSM_1663
PMU: PM1054
MSU: MS0419(luxS)
APL: APL_1216(luxS)
APJ: APJL_1229(luxS)
APA: APP7_1267
ASU: Asuc_0685
AAP: NT05HA_1914
AAT: D11S_0183
VCH: VC0557
VCO: VC0395_A0091(luxS)
VCM: VCM66_0515(luxS)
VCJ: VCD_001049
VVU: VV1_1608
VVY: VV2792
VPA: VP2537
VHA: VIBHAR_03484
VSP: VS_2562
VEX: VEA_002532
VFI: VF_0545(luxS)
VFM: VFMJ11_0557(luxS)
VSA: VSAL_I0645(luxS)
PPR: PBPRA3045
SON: SO_1101(luxS)
SDN: Sden_0981
SFR: Sfri_0947
SAZ: Sama_2541
SBL: Sbal_0922
SBM: Shew185_3440
SBN: Sbal195_3565
SBP: Sbal223_3368
SLO: Shew_2882
SPC: Sputcn32_0938
SSE: Ssed_3432
SPL: Spea_3104
SHE: Shewmr4_0934
SHM: Shewmr7_0972
SHN: Shewana3_0936
SHW: Sputw3181_3238
SHL: Shal_3188
SWD: Swoo_3618
SWP: swp_1166
PIN: Ping_3371
TCX: Tcr_2129
CSA: Csal_2049
MMW: Mmwyl1_1324
AHA: AHA_0700(luxS)
ASA: ASA_0697(luxS)
TAU: Tola_2918
DNO: DNO_0395(luxS)
NMA: NMA0463
NME: NMB1981
NMC: NMC1956
NMN: NMCC_0232
NMI: NMO_0190
NGO: NGO2102
NGK: NGK_2568
HPY: HP0105
HPJ: jhp0097
HPA: HPAG1_0105
HPS: HPSH_00525
HPG: HPG27_97(luxS)
HPP: HPP12_0107
HPB: HELPY_0104(luxS)
HHE: HH0176(ygaG)
HAC: Hac_1463(luxS)
WSU: WS2126
TDN: Suden_1938
CJE: Cj1198
CJR: CJE1332(luxS)
CJJ: CJJ81176_1213(luxS)
CJU: C8J_1142(luxS)
CJD: JJD26997_0531(luxS)
CFF: CFF8240_0111(luxS)
CCV: CCV52592_1053(luxS)
CHA: CHAB381_0546(luxS)
CCO: CCC13826_1857(luxS)
ABU: Abu_0111(luxS)
SDL: Sdel_1890
NIS: NIS_1601
SUN: SUN_0202
NAM: NAMH_0450(luxS)
DSA: Desal_3750
DPS: DP0529
BSU: BSU30670(luxS)
BHA: BH3353
BAN: BA5047(luxS)
BAR: GBAA5047(luxS)
BAA: BA_5464
BAT: BAS4687
BAH: BAMEG_5081(luxS)
BAI: BAA_5058(luxS)
BCE: BC4789
BCA: BCE_4946(luxS)
BCZ: BCZK4544(luxS)
BCR: BCAH187_A4931(luxS)
BCB: BCB4264_A4917(luxS)
BCU: BCAH820_4911(luxS)
BCG: BCG9842_B0322(luxS)
BCQ: BCQ_4606(luxS)
BCX: BCA_4922(luxS)
BCY: Bcer98_3461
BTK: BT9727_4525(luxS)
BTL: BALH_4361(luxS)
BWE: BcerKBAB4_4626
BLI: BL05306(luxS)
BLD: BLi03209(luxS)
BCL: ABC2915(luxS)
BAY: RBAM_027680(luxS)
BPU: BPUM_2705(luxS)
OIH: OB1107
GKA: GK2863
GTN: GTNG_2762
GWC: GWCH70_2789
GYC: GYMC61_0583
AFL: Aflv_0399(luxS)
SAU: SA1936(luxS)
SAV: SAV2134(luxS)
SAW: SAHV_2118(luxS)
SAM: MW2058(luxS)
SAR: SAR2222(luxS)
SAS: SAS2037
SAC: SACOL2126(luxS)
SAB: SAB2018(luxS)
SAA: SAUSA300_2088(luxS)
SAX: USA300HOU_2123(luxS)
SAO: SAOUHSC_02375
SAJ: SaurJH9_2170
SAH: SaurJH1_2208
SAE: NWMN_2038(luxS)
SAD: SAAV_2189(luxS)
SEP: SE1732
SER: SERP1741(luxS)
SHA: SH0901
SSP: SSP0751
SCA: Sca_1637(luxS)
LMO: lmo1288
LMF: LMOf2365_1306(luxS)
LMH: LMHCC_1287(luxS)
LMC: Lm4b_01298
LIN: lin1327
LWE: lwe1305(luxS)
LSP: Bsph_1699(luxS)
ESI: Exig_2345
EAT: EAT1b_0610
MCL: MCCL_1791
LLA: L65029(ycgE)
LLK: LLKF_0263(luxS)
LLC: LACR_0270
LLM: llmg_0273(luxS)
SPY: SPy_1642(luxS)
SPZ: M5005_Spy_1349(luxS)
SPM: spyM18_1653(luxS)
SPG: SpyM3_1384(luxS)
SPS: SPs0478
SPH: MGAS10270_Spy1466(luxS)
SPI: MGAS10750_Spy1458(luxS)
SPJ: MGAS2096_Spy1371(luxS)
SPK: MGAS9429_Spy1345(luxS)
SPF: SpyM50442(luxS)
SPA: M6_Spy1395
SPB: M28_Spy1390(luxS)
SOZ: Spy49_1273(luxS)
SPN: SP_0340
SPD: SPD_0309(luxS)
SPR: spr0308(luxS)
SPW: SPCG_0343(luxS)
SPX: SPG_0309(luxS)
SNE: SPN23F_03130(luxS)
SPV: SPH_0450(luxS)
SNM: SP70585_0404(luxS)
SJJ: SPJ_0332(luxS)
SPP: SPP_0375(luxS)
SNT: SPT_0389(luxS)
SAG: SAG0305(luxS)
SAN: gbs0294
SAK: SAK_0376(luxS)
SMU: SMU.474(luxS)
STC: str0394(luxS)
STL: stu0394(luxS)
STE: STER_0440
SSA: SSA_1853(luxS)
SSU: SSU05_0420
SSV: SSU98_0407
SSB: SSUBM407_0365(luxS)
SSI: SSU0376(luxS)
SSS: SSUSC84_0362(luxS)
SGO: SGO_0592(luxS)
SEQ: SZO_04010
SEZ: Sez_1565(luxS)
SEU: SEQ_1782
SUB: SUB1399(luxS)
SDS: SDEG_1705(luxS)
LPL: lp_0774(luxS)
LPJ: JDM1_0641(luxS)
LJO: LJ0631
LJF: FI9785_1597(luxS)
LAC: LBA1081(luxS)
LSL: LSL_1173(luxS)
LDB: Ldb0105(luxS)
LBU: LBUL_0088 LBUL_1233
LBR: LVIS_0340
LCA: LSEI_0765
LCB: LCABL_08310(luxS)
LGA: LGAS_1662
LRE: Lreu_1586
LRF: LAR_1486
LHE: lhv_1913
LFE: LAF_1600
LRH: LGG_00750(luxS)
LRL: LC705_00744(luxS)
PPE: PEPE_1638
EFA: EF1182(luxS)
OOE: OEOE_1562
LME: LEUM_1802
LCI: LCK_01476(luxS)
CAC: CAC2942
CPE: CPE0178(luxS)
CPF: CPF_0171(luxS)
CPR: CPR_0167(luxS)
CDF: CD3598(luxS)
CDC: CD196_3390(luxS)
CDL: CDR20291_3436(luxS)
CBO: CBO0725(luxS)
CBA: CLB_0766(luxS)
CBH: CLC_0781(luxS)
CBY: CLM_0867(luxS)
CBL: CLK_0141(luxS)
CBK: CLL_A2855(luxS) CLL_A3319(luxS)
CBB: CLD_0027(luxS)
CBI: CLJ_B0791(luxS)
CBT: CLH_2583(luxS)
CBF: CLI_0814(luxS)
CBE: Cbei_1237
CKL: CKL_1558
CKR: CKR_1449
CPY: Cphy_0889
AOE: Clos_1075
FMA: FMG_0716
EEL: EUBELI_01836
ERE: EUBREC_2602
CAR: cauri_0275
CKP: ckrop_1509
BFA: Bfae_13210
PAC: PPA0450
STP: Strop_0654
SAQ: Sare_0630
BLO: BL1152
BLJ: BLD_0910(luxS)
BLN: Blon_2000
BAD: BAD_0493
BLA: BLA_1115
BLC: Balac_0582
BLT: Balat_0582
CCU: Ccur_11080
BBU: BB0377
BBZ: BbuZS7_0379(luxS)
BGA: BG0376
BAF: BAPKO_0386
BTU: BT0377
BHR: BH0377
BDU: BDU_372
BRE: BRE_376
BVU: BVU_0895
PGI: PG0498(luxS)
PGN: PGN_1474
COC: Coch_1216
LBA: Lebu_1770
STR: Sterm_0261
DRA: DR_2387
DGE: Dgeo_2248
DDR: Deide_01300(luxS)
TTH: TTC1186(luxS)
TTJ: TTHA1551
 |
|---|
| Structures |
PDB: 1JQW 2FQO 2FQT |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:12705835]
Zhu J, Dizin E, Hu X, Wavreille AS, Park J, Pei D.
S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein.
Biochemistry. 42 (2003) 4717-26.
Bacillus subtilis [GN:bsu] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:11544353]
Miller MB, Bassler BL.
Quorum sensing in bacteria.
Annu. Rev. Microbiol. 55 (2001) 165-99.
Vibrio harveyi [GN:vha] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.4.1.21
IUBMB Enzyme Nomenclature: 4.4.1.21
ExPASy - ENZYME nomenclature database: 4.4.1.21
BRENDA, the Enzyme Database: 4.4.1.21
CAS: 37288-63-4 |
|---|
