KEGG   ENZYME: 4.4.1.24Help
Entry
EC 4.4.1.24                 Enzyme                                 

Name
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambiguous)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
Reaction(IUBMB)
(2R)-3-sulfolactate = pyruvate + bisulfite [RN:R07633]
Reaction(KEGG)
Substrate
(2R)-3-sulfolactate [CPD:C11537]
Product
pyruvate [CPD:C00022];
bisulfite [CPD:C11481]
Comment
Requires iron(II). This inducible enzyme participates in cysteate degradation in Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation in Chromohalobacter salexigens. The enzyme is specific for the (R) isomer.
History
EC 4.4.1.24 created 2006, modified 2011
Pathway
Cysteine and methionine metabolism
Orthology
K16845  
(2R)-sulfolactate sulfo-lyase subunit alpha
K16846  
(2R)-sulfolactate sulfo-lyase subunit beta
Genes
CSA: 
RPJ: 
REU: 
CTI: 
BUO: 
BPT: 
AXY: 
AXO: 
AXN: 
AXS: 
AKA: 
AMIM: 
VEI: 
VAP: 
VPD: 
HAR: 
RGE: 
BPRC: 
DVM: 
DDS: 
DBA: 
DRT: 
DTI: 
OCA: 
OCG: 
OCO: 
MRD: 
MNO: 
RVA: 
DSH: 
PUB: 
APM: 
PSAB: 
DSY: 
DHD: 
DDH: 
DDL: 
DKU: 
DRU: 
DGI: 
SAY: 
SAP: 
MAS: 
RHA: 
MPH: 
RXY: 
MRB: 
MRE: 
MSV: 
TNA: 
TTA: 
DTU: 
TAC: 
SSO: 
SOL: 
STO: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
AHO: 
CMA: 
TUZ: 
VMO: 
 » show all
Taxonomy
Reference
1  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat. Prod. Rep. 19 (2002) 133-47.
Reference
2  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM.
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology. 151 (2005) 737-47.
  Sequence
Reference
3  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology. 156 (2010) 967-74.
  Sequence
[csa:Csal_1766]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
1256650-35-7

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