| Entry |
|
|---|
| Name |
L-3-cyanoalanine synthase;
beta-cyanoalanine synthase;
beta-cyanoalanine synthetase;
beta-cyano-L-alanine synthase;
L-cysteine hydrogen-sulfide-lyase (adding HCN) |
|---|
| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide;
L-3-cyanoalanine-forming) |
|---|
| Reaction(IUBMB) |
L-cysteine + hydrogen cyanide = L-3-cyanoalanine + hydrogen sulfide
[RN:R03524] |
|---|
| Reaction(KEGG) |
R03524;
(other) R02846
 |
|---|
| Substrate |
L-cysteine [CPD:C00097];
hydrogen cyanide [CPD:C01326] |
|---|
| Product |
L-3-cyanoalanine [CPD:C02512];
hydrogen sulfide [CPD:C00283] |
|---|
| Comment |
Contains pyridoxal phospate. |
|---|
| Pathway |
PATH: ec00460 Cyanoamino acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13034 L-3-cyanoalanine synthase/ cysteine synthase |
|---|
| Genes |
ATH: AT3G61440(CYSC1)
POP: POPTR_244580
RCU: RCOM_1615850
VVI: 100255091(GSVIVT00026889001)
OSA: 4335048(Os04g0165700)
SBI: SORBI_06g001610(SORBIDRAFT_06g001610)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:1055433]
Akopyan TN, Braunstein AE, Goryachenkova EV.
Beta-cyanoalanine synthase: purification and characterization.
Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 1617-21.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5001194]
Castric PA, Conn EE.
Formation of -cyanoalanine by O-acetylserine sulfhydrylase.
J. Bacteriol. 108 (1971) 132-6.
Bacillus megaterium |
|---|
Reference
Authors
Title
Journal
|
3
Hendrickson, H.R.
The beta-cyanoalanine synthase of blue lupine.
Fed. Proc. 27 (1968) 593. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:5769995]
Hendrickson HR, Conn EE.
Cyanide metabolism in higher plants. IV. Purification and properties
of the beta-cyanolanine synthase of blue lupine.
J. Biol. Chem. 244 (1969) 2632-40.
Lupinus angustifolia |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.4.1.9
IUBMB Enzyme Nomenclature: 4.4.1.9
ExPASy - ENZYME nomenclature database: 4.4.1.9
BRENDA, the Enzyme Database: 4.4.1.9
CAS: 9059-53-4 |
|---|
