| Entry |
|
|---|
| Name |
phosphatidylinositol diacylglycerol-lyase;
monophosphatidylinositol phosphodiesterase;
phosphatidylinositol phospholipase C;
1-phosphatidylinositol phosphodiesterase;
1-phosphatidyl-D-myo-inositol inositolphosphohydrolase
(cyclic-phosphate-forming);
1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase
(1,2-cyclic-phosphate-forming) |
|---|
| Class |
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase
(1D-myo-inositol-1,2-cyclic-phosphate-forming) |
|---|
| Reaction(IUBMB) |
1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic
phosphate + 1,2-diacyl-sn-glycerol [RN:R03364] |
|---|
| Reaction(KEGG) |
R03364;
(other) R03332
 |
|---|
| Substrate |
1-phosphatidyl-1D-myo-inositol [CPD:C01194] |
|---|
| Product |
1D-myo-inositol 1,2-cyclic phosphate [CPD:C04299];
1,2-diacyl-sn-glycerol [CPD:C00641] |
|---|
| Comment |
This enzyme is bacterial. Activity is also found in animals, but
this activity is due to the presence of EC 3.1.4.11,
phosphoinositide phospholipase C. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism |
|---|
| Orthology |
KO: K01771 1-phosphatidylinositol phosphodiesterase |
|---|
| Genes |
GGA: 770019
TGU: 100218968
DRE: 100006223(DKEY-266F7.9)
AGO: AGOS_AFR607C
LTH: KLTH0H11308g
DHA: DEHA0G04807g
PIC: PICST_70308
PPA: PAS_chr4_0907
LEL: LELG_01298
CAL: CaO19.13219(PLC21) CaO19.1586(PLC2)
CTP: CTRG_01321 CTRG_01371
CDU: CD36_17390(PLC22) CD36_17810
YLI: YALI0D10813g
NCR: NCU09135
PAN: PODANSg09605
MGR: MGG_04834
FGR: FG00423.1 FG05655.1
ANI: AN3636.2
AFM: AFUA_4G12000
AOR: AO090003001009
ANG: An01g07280
AFV: AFLA_028080
PCS: Pc22g05150
NFI: NFIA_104240
CIM: CIMG_01631
URE: UREG_05354
SSL: SS1G_06734 SS1G_12385
BFU: BC1G_14570
LBC: LACBIDRAFT_315813 LACBIDRAFT_318365 LACBIDRAFT_335698
MPR: MPER_09363
UMA: UM04644.1
TET: TTHERM_00426140
TVA: TVAG_301070 TVAG_372910
HSO: HS_1585
HSM: HSM_0426
BVI: Bcep1808_5289
BUR: Bcep18194_B0943
BCN: Bcen_3596
BCH: Bcen2424_4771
BCM: Bcenmc03_5512
BCJ: BCAM1969
BAM: Bamb_4154
BAC: BamMC406_4678
BAN: BA3891
BAR: GBAA3891
BAA: BA_4362
BAT: BAS3604
BAH: BAMEG_0741
BAI: BAA_3915
BCE: BC3761
BCA: BCE_3793
BCZ: BCZK3513
BCR: BCAH187_A3801
BCB: BCB4264_A3860
BCU: BCAH820_3771
BCG: BCG9842_B1438 BCG9842_B1713
BCQ: BCQ_3547
BCX: BCA_3856
BTK: BT9727_3501
BTL: BALH_3388
BWE: BcerKBAB4_2347 BcerKBAB4_3532
SAU: SA0091(plc)
SAV: SAV0095(plc)
SAW: SAHV_0094(plc)
SAM: MW0070(plc)
SAR: SAR0105(plc)
SAC: SACOL0078(plc)
SAB: SAB0038(plc)
SAA: SAUSA300_0099(plc)
SAX: USA300HOU_0108(plc)
SAO: SAOUHSC_00051
SAJ: SaurJH9_0083
SAH: SaurJH1_0086
SAE: NWMN_0041
SAD: SAAV_0043
LMO: lmo0201(plcA)
LMF: LMOf2365_0212(plcA)
LMH: LMHCC_2442
LMC: Lm4b_00198(plcA)
LSP: Bsph_1112
SGR: SGR_3955
FAL: FRAAL3352
CAI: Caci_6736
BFR: BF1750
DFE: Dfer_0819
CPI: Cpin_5471
 |
|---|
| Structures |
PDB: 1T6M 2OR2 3EA1 3EA2 3EA3 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4377210]
Allan D, Michell RH.
Phosphatidylinositol cleavage catalysed by the soluble fraction from
lymphocytes. Activity at pH5.5 and pH7.0.
Biochem. J. 142 (1974) 591-7.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4294905]
Friedel RO, Brown JD, Durell.
Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig
brain.
Biochim. Biophys. Acta. 144 (1967) 684-6.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6297738]
Irvine RF.
The enzymology of stimulated inositol lipid turnover.
Cell. Calcium. 3 (1982) 295-309.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:236918]
Michell RH, Allan D.
Inositol cyclis phosphate as a product of phosphatidylinositol
breakdown by phospholipase C (Bacillus cereus).
FEBS. Lett. 53 (1975) 302-4.
Bacillus cereus |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:588258]
Low MG, Finean JB.
Release of alkaline phosphatase from membranes by a
phosphatidylinositol-specific phospholipase C.
Biochem. J. 167 (1977) 281-4.
Staphylococcus aureus |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:3194218]
Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG.
Sequence of the Bacillus thuringiensis phosphatidylinositol specific
phospholipase C.
Nucleic. Acids. Res. 16 (1988) 10383.
Bacillus thuringiensis |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.6.1.13
IUBMB Enzyme Nomenclature: 4.6.1.13
ExPASy - ENZYME nomenclature database: 4.6.1.13
BRENDA, the Enzyme Database: 4.6.1.13
CAS: 37288-19-0 |
|---|
