KEGG   ENZYME: 4.6.1.2Help
Entry
EC 4.6.1.2                  Enzyme                                 

Name
guanylate cyclase;
guanylyl cyclase;
guanyl cyclase;
GTP diphosphate-lyase (cyclizing)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Reaction(IUBMB)
GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Reaction(KEGG)
Substrate
GTP [CPD:C00044]
Product
3',5'-cyclic GMP [CPD:C00942];
diphosphate [CPD:C00013]
Comment
Also acts on ITP and dGTP.
History
EC 4.6.1.2 created 1972
Pathway
Purine metabolism
Orthology
K01769  
guanylate cyclase, other
K12318  
guanylate cyclase soluble subunit alpha
K12319  
guanylate cyclase soluble subunit beta
K12320  
heat-stable enterotoxin receptor
K12321  
guanylate cyclase 2D/E
K12322  
guanylate cyclase 2F
K12323  
atrial natriuretic peptide receptor A
K12324  
atrial natriuretic peptide receptor B
Genes
HSA: 
2977(GUCY1A2) 2982(GUCY1A3) 2983(GUCY1B3) 2984(GUCY2C) 2986(GUCY2F) 3000(GUCY2D) 4881(NPR1) 4882(NPR2)
PTR: 
100608597(GUCY1A3) 452727(GUCY1B2) 457329(NPR1) 461565(GUCY1B3) 465084(NPR2) 465806(GUCY2F) 466769(GUCY1A2) 473375(GUCY2C) 750641(GUCY2D)
PPS: 
100975209(GUCY2C) 100976525(GUCY2D) 100980358 100983770(NPR1) 100984343(GUCY2F) 100984704(GUCY1B3) 100985928(GUCY1A3) 100987635(GUCY1A2) 100991030(NPR2)
GGO: 
101128425 101131617(NPR1) 101134962(GUCY2F) 101139175(GUCY1A3) 101140749(GUCY2D) 101141380(GUCY1B3) 101145371 101145840(NPR2) 101146114
PON: 
100172608(GUCY1A3) 100434873(GUCY1B3) 100437411(NPR2) 100442459(NPR1) 100443214(GUCY2D) 100445008 100445361(GUCY1A2) 100451211(GUCY2F) 100460918(GUCY2C)
NLE: 
100581660(GUCY1A3) 100583335(GUCY1B3) 100585866(GUCY2D) 100588933(GUCY2F) 100592351(GUCY1A2) 100594944(GUCY2C) 100595720(NPR2) 100600502 100601694(NPR1)
MCC: 
100424944(GUCY1B3) 695750(NPR2) 699191(GUCY2C) 699365(GUCY1A3) 704485(GUCY2F) 706615(GUCY1A2) 715598(NPR1) 716734(GUCY2D)
MCF: 
101866366(GUCY1A3) 101866588(GUCY1B3) 102120445 102127299(GUCY1A2) 102129950(GUCY2F) 102130850(GUCY2C) 102136908(NPR2) 102143449(NPR1) 102146353(GUCY2D)
RRO: 
104655958 104658100(GUCY1A3) 104658102(GUCY1B3) 104661674(GUCY2D) 104661940(GUCY1A2) 104662724 104663522(NPR1) 104666399(GUCY2C) 104672382(NPR2) 104674410(GUCY2F)
CJC: 
100387768(GUCY1A2) 100390920 100395297(GUCY1B3) 100396127(GUCY1A3) 100396371(NPR1) 100406002(GUCY2C) 100410561(GUCY2F) 100410630(NPR2) 100412242(GUCY2D)
MMU: 
14917(Gucy2c) 14918(Gucy2d) 14919(Gucy2e) 18160(Npr1) 230103(Npr2) 234889(Gucy1a2) 239134(Gucy1b2) 245650(Gucy2f) 54195(Gucy1b3) 60596(Gucy1a3)
RNO: 
113911(Gucy2d) 116556(Gucy2f) 116564(Npr2) 24603(Npr1) 25202(Gucy1b3) 25206(Gucy1b2) 25711(Gucy2c) 497757(Gucy1a3) 66012(Gucy1a2) 79222(Gucy2e)
CGE: 
100752423(Npr1) 100752832 100754759(Gucy2d) 100755503 100757969(Gucy2c) 100768699(Gucy1a3) 100769238(Gucy1a2) 100772356(Npr2) 100772822(Gucy1b3)
NGI: 
103727194 103731324(Gucy1a2) 103741534(Npr2) 103750026(Gucy2f) 103751001(Gucy1a3) 103751002(Gucy1b3) 103751781(Npr1) 103752104(Gucy2d) 103752330(Gucy2c)
HGL: 
101697777(Gucy2d) 101702803(Gucy1a2) 101707903(Gucy2f) 101712380(Npr2) 101712487(Gucy1a3) 101714641(Npr1) 101720874(Gucy2c) 101724888(Gucy1b3) 101726611
OCU: 
100008740(GUCY2C) 100340698(GUCY2F) 100343663(NPR1) 100344095(GUCY2D) 100349851(GUCY1B3) 100350099(GUCY1A3) 100356598(NPR2) 100357621(GUCY1A2)
TUP: 
102469297(GUCY1A2) 102482734(NPR1) 102483882(GUCY1A3) 102485635 102488370(GUCY1B3) 102494681 102495739(GUCY2C) 102496410(GUCY2D) 102502023(NPR2)
CFA: 
403863(GUCY2D) 474762(NPR2) 479455(GUCY1A2) 481016(GUCY2F) 482663(GUCY1A3) 485179 485435 486671(GUCY2C) 490455(NPR1) 553102(GUCY1B3)
AML: 
100464538(GUCY1A2) 100468070 100468576(GUCY2C) 100469110(GUCY2F) 100472601(NPR2) 100472771(NPR1) 100476540 100480095(GUCY2D) 100481364(GUCY1B3) 100483617(GUCY1A3)
UMR: 
103658044(GUCY1A3) 103658045(GUCY1B3) 103662433(GUCY1A2) 103667090(NPR2) 103668723(NPR1) 103677696 103677772(GUCY2C) 103679746(GUCY2F)
FCA: 
101080682(NPR1) 101089435(GUCY1B3) 101090242(GUCY2F) 101094301(NPR2) 101095109(GUCY2C) 101098377(GUCY1A3) 101098598 101099494(GUCY1A2) 101101009(GUCY2D)
PTG: 
102949070(NPR2) 102949926(GUCY2F) 102955254(NPR1) 102956040(GUCY1A2) 102960287(GUCY2D) 102963095(GUCY2C) 102963951(GUCY1B3) 102969669(GUCY1A3) 102970885
BTA: 
100295021(GUCY2E) 107131161 281216(GUCY1A3) 281357(NPR2) 282244(GUCY2C) 282245(GUCY2D) 282246(GUCY2F) 282433(GUCY1B3) 533048(NPR1) 613600(GUCY1A2)
BOM: 
102274513(GUCY2F) 102278070(NPR2) 102279810(NPR1) 102280817(GUCY1A2) 102281141(GUCY2D) 102281834(GUCY1A3) 102282106(GUCY1B3) 102284444(GUCY2C) 102285947
PHD: 
102316801(NPR2) 102319851(GUCY2F) 102325669 102326726(GUCY2D) 102328814(GUCY1A2) 102329923(NPR1) 102332578(GUCY1B3) 102341269 102341664(GUCY2C)
CHX: 
100861577(NPR2) 102169406(GUCY1B3) 102169418(GUCY2D) 102169692(GUCY1A3) 102180380(GUCY2F) 102182418 102184168(GUCY1A2) 102186447(NPR1)
OAS: 
101104339(GUCY1A2) 101106088 101108212(GUCY2C) 101110000(GUCY1A3) 101112033(GUCY2F) 101112950(NPR2) 101120932(GUCY2D) 101123436(NPR1) 106990802 443165(GUCY1B3)
SSC: 
100153508(NPR1) 100512698(NPR2) 100522091(GUCY1A2) 100523457 100625149 100625536 100737736(GUCY2F) 397193(GUCY2C) 444999(GUCY1B3) 553100(GUCY1A3)
CFR: 
102503713(GUCY2D) 102507709(NPR2) 102508002(GUCY1A3) 102508234(GUCY1B3) 102510749 102514869(NPR1) 102516411(GUCY2C) 102522209 102523651(GUCY1A2)
BACU: 
102998599(GUCY2F) 103002831(NPR2) 103006662(GUCY2C) 103006879(NPR1) 103007177(GUCY1A2) 103016360(GUCY2D) 103020709(GUCY1B3) 103020943 103020991
LVE: 
103069938(GUCY1A2) 103070106(GUCY2D) 103071136(GUCY2F) 103075302 103075578(GUCY1B3) 103081407(GUCY2C) 103087466(NPR2) 103088382(NPR1)
ECB: 
100054420 100054502(GUCY2F) 100055416(NPR2) 100061959(NPR1) 100063810(GUCY2C) 100069474(GUCY1A2) 100069551(GUCY1B3) 100069573(GUCY1A3) 100073037(GUCY2D)
MYB: 
102238967(NPR2) 102241126(GUCY2F) 102243506(GUCY2D) 102247939(GUCY2C) 102249825(NPR1) 102250379(GUCY1B3) 102250686(GUCY1A3) 102260196(GUCY1A2) 102261219
MYD: 
102755806(NPR1) 102758657 102760543 102764771(GUCY1A3) 102767033(GUCY1A2) 102769452(GUCY1B3) 102771508(NPR2) 102772626(GUCY2C)
PALE: 
102878600(GUCY2F) 102879793(NPR1) 102883474(GUCY2C) 102885265(NPR2) 102889391 102889502(GUCY1A3) 102889920(GUCY1B3) 102892708(GUCY2D) 102896673(GUCY1A2)
MDO: 
100014788(GUCY2D) 100016988(GUCY2C) 100017038(GUCY1A3) 100019736(NPR1) 100020156(NPR2) 100024008(GUCY1B3) 100027037(GUCY1A2) 100028110 100028289
SHR: 
100921433(GUCY2D) 100921526(NPR1) 100925538(GUCY2C) 100928661(GUCY1A3) 100929308(GUCY1A2) 100931427(GUCY1B3) 100932257 100932333(NPR2)
OAA: 
100074490 100075186(GUCY1A3) 100077965(GUCY1A2) 100079900(GUCY1B3) 100082922 100087666(NPR2) 100091310(GUCY2C)
GGA: 
100859339(NPR2) 417968(GUCY2C) 419089(GUCY2F) 422407(GUCY1A3) 422408(GUCY1B3) 429128(GUCY1B4) 771678(GUCY1A2)
MGP: 
100539100 100539537(NPR2) 100542159(GUCY1A2) 100544016(GUCY2F) 100547213(GUCY1A3) 100547365(GUCY1B3) 100550786(GUCY2C)
APLA: 
101790692(GUCY1A2) 101796516 101799600(GUCY1A3) 101800833(GUCY2F) 101802157(GUCY2C) 101805092 101805193(GUCY1B3) 106019034
TGU: 
100217644(GUCY1A2) 100223544(GUCY1B3) 100223563(GUCY1A3) 100225337 100227153(NPR2) 100228246(GUCY2C) 100229764(GUCY2F)
GFR: 
102038803(GUCY2F) 102038841 102039158(NPR2) 102042400(GUCY2C) 102043713(GUCY1B3) 102043874(GUCY1A3) 102044723(GUCY1A2)
FAB: 
101807229(NPR2) 101809957 101812872(GUCY1A2) 101814320(GUCY1A3) 101815504(GUCY1B3) 101816039(GUCY2C) 101816994(GUCY2F) 101818523 101822049
PHI: 
102099657(GUCY2F) 102105071 102105257(NPR2) 102106220(GUCY1A3) 102106413(GUCY1B3) 102111535(GUCY2C) 102113474(GUCY1A2) 102114027(GUCY2D) 106628815(NPR1)
CCW: 
104686575(NPR2) 104690109(GUCY1A2) 104690280(GUCY2F) 104693425 104696375(GUCY2C) 104697178(GUCY1A3) 104697179(GUCY1B3)
FPG: 
101913205(GUCY2C) 101914436(GUCY1A2) 101915374(GUCY1B3) 101916520 101916740(NPR2) 101920979 101922339(GUCY1A3) 101924821(GUCY2F)
FCH: 
102046999(GUCY1A3) 102048540(GUCY1B3) 102051925(NPR2) 102053014(GUCY2C) 102054518 102055553(GUCY2F) 102059430(GUCY1A2)
CLV: 
102086091(GUCY2F) 102090855(GUCY1A3) 102091284 102091873(GUCY1B3) 102095707 102097001(NPR1) 102097143(GUCY1A2) 102098846(NPR2) 102098904(GUCY2C)
ASN: 
102368327(NPR2) 102373414(NPR1) 102373559(GUCY2F) 102374400(GUCY2C) 102375187(GUCY2D) 102375853 102383096(GUCY1B3) 102383277(GUCY1A2) 102383335(GUCY1A3) 102385932
AMJ: 
PSS: 
102444148(GUCY2C) 102444454(GUCY1A2) 102446826(GUCY1A3) 102447071(GUCY1B3) 102451086(GUCY2D) 102451605 102452749
CMY: 
102931425 102933143(NPR2) 102934622(GUCY1A2) 102938442(GUCY1A3) 102938663(GUCY1B3) 102945517(NPR1) 102947911(GUCY2C) 102948195
ACS: 
PBI: 
103052637 103052921(GUCY1A2) 103056579(NPR1) 103057412 103062751(GUCY2F) 103063344(GUCY1A3) 103063696 103063891(GUCY1B3) 103067773(GUCY2C)
XLA: 
378662(gucy2c) 399070(npr1) 399350(npr2) 432281(gucy1b3)
XTR: 
100145454(gucy1a2) 100379900(gucy1b3) 100486678(gucy2c) 100488543(npr2) 100489435 100492092(npr1) 100492820(gucy2f) 100496590(gucy2d) 100496677(gucy1a3) 100496697(gucy1b2)
DRE: 
100150304(gucy1b3) 100331745 140424(gucy2f) 140425(gc2) 140426(gc3) 550420(gucy1a3) 557191(gucy1b2) 560653(npr1a) 568219 572052
TRU: 
MZE: 
OLA: 
100049177(gucy1a3) 100049178(gucy1b3) 100049183(npr2) 100049189(olgc-r1) 100049248(gucy1a2) 100125799(olgc2) 100125818(olgc9) 100125819(olgc7) 100125820(olgc6) 100216004(olgc-r2) 101172871(gucy1a3)
XMA: 
LCM: 
CMK: 
103172259 103177390 103179559(gucy2f) 103181010(npr2) 103185780(gucy1a2) 103187183(gucy1a3) 103187184(gucy1b3) 103187614
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
Dmel_CG1470(Gycbeta100B) Dmel_CG14885(Gyc-89Da) Dmel_CG14886(Gyc-89Db) Dmel_CG1912(Gycalpha99B) Dmel_CG31183 Dmel_CG3216 Dmel_CG33114(Gyc32E) Dmel_CG34357 Dmel_CG4154(Gyc88E)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE10920(dyak_GLEANR_10803) Dyak_GE12966(dyak_GLEANR_1321) Dyak_GE13756(dyak_GLEANR_13938) Dyak_GE23868(dyak_GLEANR_7617) Dyak_GE24273(dyak_GLEANR_7984) Dyak_GE24401(dyak_GLEANR_8101) Dyak_GE24402(dyak_GLEANR_8102) Dyak_GE25345(dyak_GLEANR_8962) Dyak_GE26352(dyak_GLEANR_9900)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408879(sGC-alpha1) 408880(Gycbeta1) 409422(GB11811) 411635(sGCbeta-3) 413274(GB10150) 724571(GB10108) 726069
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CELE_AH6.1(gcy-1) CELE_C46E1.2(gcy-36) CELE_C49H3.1(gcy-8) CELE_F08B1.2(gcy-12) CELE_F21H7.9(gcy-20) CELE_F22E5.3(gcy-21) CELE_F57F5.2(gcy-33) CELE_M04G12.3(gcy-34) CELE_R134.1(gcy-3) CELE_R134.2(gcy-2) CELE_T01A4.1(gcy-28) CELE_T04D3.4(gcy-35) CELE_T07D1.1(gcy-31) CELE_T26C12.4(gcy-23) CELE_W03F11.2(gcy-17) CELE_ZC239.7(gcy-15) CELE_ZC412.2(gcy-14) CELE_ZK896.8(gcy-18) CELE_ZK970.6(gcy-5)
CBR: 
CBG02110(Cbr-gcy-31) CBG03898 CBG07710 CBG14865(Cbr-gcy-28) CBG20390(Cbr-gcy-35) CBG23350(Cbr-gcy-33)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
MBR: 
SRE: 
ACAN: 
PFA: 
MAL13P1.301(gc-betA)
PYO: 
PKN: 
TPS: 
PSOJ: 
TVA: 
PAT: 
MFA: 
MMB: 
MEH: 
BRA: 
BBT: 
JAN: 
TER: 
 » show all
Taxonomy
Reference
1  [PMID:235291]
  Authors
Garbers DL, Suddath JL, Hardman JG.
  Title
Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity.
  Journal
Biochim. Biophys. Acta. 377 (1975) 174-85.
Reference
2  [PMID:4982201]
  Authors
Hardman JG, Sutherland EW.
  Title
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate.
  Journal
J. Biol. Chem. 244 (1969) 6363-70.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-75-5

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