KEGG   ENZYME: 4.6.1.2Help
Entry
EC 4.6.1.2                  Enzyme                                 
Name
guanylate cyclase;
guanylyl cyclase;
guanyl cyclase;
GTP diphosphate-lyase (cyclizing)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Reaction(IUBMB)
GTP = 3',5'-cyclic GMP + diphosphate [RN:R00434]
Reaction(KEGG)
Substrate
GTP [CPD:C00044]
Product
3',5'-cyclic GMP [CPD:C00942];
diphosphate [CPD:C00013]
Comment
Also acts on ITP and dGTP.
Pathway
Purine metabolism
Orthology
K01769  
guanylate cyclase, other
K12318  
guanylate cyclase soluble subunit alpha
K12319  
guanylate cyclase soluble subunit beta
K12320  
heat-stable enterotoxin receptor
K12321  
guanylate cyclase 2D/E/F
K12323  
atrial natriuretic peptide receptor A
K12324  
atrial natriuretic peptide receptor B
Genes
HSA: 
2977(GUCY1A2) 2982(GUCY1A3) 2983(GUCY1B3) 2984(GUCY2C) 2986(GUCY2F) 3000(GUCY2D) 4881(NPR1) 4882(NPR2)
PTR: 
100608597(GUCY1A3) 452727(GUCY1B2) 457329(NPR1) 461565(GUCY1B3) 465084(NPR2) 465806(GUCY2F) 466769(GUCY1A2) 473375(GUCY2C) 750641(GUCY2D)
PPS: 
100975209(GUCY2C) 100976525(GUCY2D) 100980358 100983770(NPR1) 100984343(GUCY2F) 100984704(GUCY1B3) 100985928(GUCY1A3) 100987635(GUCY1A2) 100991030(NPR2)
GGO: 
101128425 101134962(GUCY2F) 101139175(GUCY1A3) 101140749(GUCY2D) 101141380(GUCY1B3) 101145840(NPR2) 101146114
PON: 
100172608(GUCY1A3) 100434873(GUCY1B3) 100437411(NPR2) 100442459 100443214(GUCY2D) 100445008 100445361(GUCY1A2) 100451211(GUCY2F) 100460918(GUCY2C)
MCC: 
100424944(GUCY1B3) 695750(NPR2) 699191(GUCY2C) 699365(GUCY1A3) 704485(GUCY2F) 706615(GUCY1A2) 715598(NPR1) 716734(GUCY2D)
MMU: 
14917(Gucy2c) 14918(Gucy2d) 14919(Gucy2e) 18160(Npr1) 230103(Npr2) 234889(Gucy1a2) 239134(Gucy1b2) 245650(Gucy2f) 54195(Gucy1b3) 60596(Gucy1a3)
RNO: 
113911(Gucy2d) 116556(Gucy2f) 116564(Npr2) 24603(Npr1) 25202(Gucy1b3) 25206(Gucy1b2) 25711(Gucy2c) 497757(Gucy1a3) 66012(Gucy1a2) 79222(Gucy2e)
CFA: 
403863(GUCY2D) 474762(NPR2) 479455(GUCY1A2) 481016(GUCY2F) 482663(GUCY1A3) 485179 485435 486671(GUCY2C) 490455(NPR1) 553102(GUCY1B3)
AML: 
FCA: 
101080682(NPR1) 101089435(GUCY1B3) 101090242(GUCY2F) 101094301(NPR2) 101095109(GUCY2C) 101098377(GUCY1A3) 101098598 101099494(GUCY1A2) 101099582 101101009
BTA: 
100295021(GUCY2E) 281216(GUCY1A3) 281357(NPR2) 282244(GUCY2C) 282245(GUCY2D) 282246(GUCY2F) 282433(GUCY1B3) 510388 533048(NPR1) 613600(GUCY1A2)
SSC: 
100153508(NPR1) 100512698(NPR2) 100522091(GUCY1A2) 100625149 100625536 397193(GUCY2C) 444999(GUCY1B3) 553100(GUCY1A3)
ECB: 
100054420 100054502(GUCY2F) 100055416(NPR2) 100061959(NPR1) 100063810 100069551 100069573(GUCY1A3)
MDO: 
100014788 100016988(GUCY2C) 100017038(GUCY1A3) 100019736(NPR1) 100020156(NPR2) 100024008 100027037 100028110 100028289
SHR: 
100921433 100921526(NPR1) 100925538(GUCY2C) 100928661(GUCY1A3) 100929308(GUCY1A2) 100931427(GUCY1B3) 100932093 100932257 100932333(NPR2)
OAA: 
100074490 100075186 100077965 100079900(GUCY1B3) 100082922 100087666(NPR2) 100091310
GGA: 
100859339 417968(GUCY2C) 419089(GUCY2F) 422407(GUCY1A3) 422408(GUCY1B3) 429128(GUCY1B2) 771678(GUCY1A2)
MGP: 
100539100 100539537 100542159(GUCY1A2) 100544016 100547213(GUCY1A3) 100547365 100550786
TGU: 
100217644(GUCY1A2) 100223544(GUCY1B3) 100223563(GUCY1A3) 100225337 100227153(NPR2) 100228246(GUCY2C) 100229764
ACS: 
100554615(gucy1a2) 100556814 100558820 100563021 100563220 100563369(gucy2c) 100565491 100568215(npr2)
XLA: 
378662(gucy2c) 399070(npr1) 399350(npr2) 432281(gucy1b3)
XTR: 
100145454(gucy1a2) 100379900(gucy1b3) 100486678 100492092 100492820(gucy2f) 100496590 100496677 100496697
DRE: 
100150304(gucy1b3) 100330875 140424(gucy2f) 140425(gc2) 550420(gucy1a3) 557191 560653(npr1a) 568219
TRU: 
101068241 101068334 101069264 101072043 101074666 445898(frgcs-beta1) 446059(frgcs-alpha1)
OLA: 
100049177(gucy1a3) 100049178(gucy1b3) 100049183(npr2) 100049189(olgc-r1) 100049248(olgcs-alpha2) 100125799(olgc2) 100125818(olgc9) 100125819(olgc7) 100125820(olgc6) 100216004(olgc-r2)
BFO: 
BRAFLDRAFT_153964 BRAFLDRAFT_241200 BRAFLDRAFT_241945 BRAFLDRAFT_56822
CIN: 
100177156 100178308 100178591
SPU: 
100889569 100890426 373321 576434(npr1) 577615 579464 581605
DME: 
Dmel_CG1470(Gycbeta100B) Dmel_CG14885(Gyc-89Da) Dmel_CG1912(Gycalpha99B) Dmel_CG31183 Dmel_CG3216 Dmel_CG33114(Gyc32E) Dmel_CG34357
DPO: 
Dpse_GA13187 Dpse_GA13322 Dpse_GA15127 Dpse_GA16072 Dpse_GA16724 Dpse_GA25709
DAN: 
Dana_GF12732 Dana_GF15131 Dana_GF16472 Dana_GF18416 Dana_GF18501 Dana_GF23359
DER: 
Dere_GG10321 Dere_GG11679 Dere_GG11792 Dere_GG17008 Dere_GG20300 Dere_GG20817
DPE: 
Dper_GL10193 Dper_GL13540 Dper_GL13901 Dper_GL18585 Dper_GL21728 Dper_GL22179
DSE: 
Dsec_GM11125 Dsec_GM12804 Dsec_GM12922 Dsec_GM15161 Dsec_GM15763 Dsec_GM25747
DSI: 
Dsim_GD19104 Dsim_GD20320 Dsim_GD21450 Dsim_GD21561 Dsim_GD22188 Dsim_GD25238
DWI: 
Dwil_GK11859 Dwil_GK11912 Dwil_GK14484 Dwil_GK15240 Dwil_GK22614 Dwil_GK23254
DYA: 
Dyak_GE10920 Dyak_GE12966 Dyak_GE13756 Dyak_GE23868 Dyak_GE24401 Dyak_GE26352
DGR: 
Dgri_GH10964 Dgri_GH13975 Dgri_GH13987 Dgri_GH18909 Dgri_GH19289 Dgri_GH21377
DMO: 
Dmoj_GI18553 Dmoj_GI22319 Dmoj_GI23408 Dmoj_GI24643
DVI: 
Dvir_GJ10256 Dvir_GJ10506 Dvir_GJ10614 Dvir_GJ14934 Dvir_GJ20348 Dvir_GJ23465
AGA: 
AgaP_AGAP000214 AgaP_AGAP000280 AgaP_AGAP003283 AgaP_AGAP008691 AgaP_AGAP008848
AAG: 
AaeL_AAEL001457 AaeL_AAEL005330 AaeL_AAEL005442 AaeL_AAEL006806 AaeL_AAEL011318 AaeL_AAEL015372
CQU: 
CpipJ_CPIJ000998 CpipJ_CPIJ001417 CpipJ_CPIJ009261 CpipJ_CPIJ010180 CpipJ_CPIJ017081
AME: 
408879(sGC-alpha1) 408880(Gycbeta1) 724571 726069
NVI: 
100116869(NV18341) 100118554(NV15836) 100118663(NV15839) 100120090(NV16324)
TCA: 
100141543(GLEAN_04747) 657050 659006 659086 664507
API: 
100160678 100167238 100167260
PHU: 
Phum_PHUM100000 Phum_PHUM360550 Phum_PHUM588150 Phum_PHUM588470 Phum_PHUM591960
ISC: 
IscW_ISCW008060 IscW_ISCW011096 IscW_ISCW017463
CEL: 
CELE_AH6.1(gcy-1) CELE_C46E1.2(gcy-36) CELE_C49H3.1(gcy-8) CELE_F08B1.2(gcy-12) CELE_F21H7.9(gcy-20) CELE_F22E5.3(gcy-21) CELE_M04G12.3(gcy-34) CELE_R134.1(gcy-3) CELE_R134.2(gcy-2) CELE_T04D3.4(gcy-35) CELE_T26C12.4(gcy-23) CELE_W03F11.2(gcy-17) CELE_ZC239.7(gcy-15) CELE_ZC412.2(gcy-14) CELE_ZK896.8(gcy-18) CELE_ZK970.6(gcy-5)
CBR: 
CBG03898 CBG07710 CBG14865(Cbr-gcy-28) CBG20390(Cbr-gcy-35)
BMY: 
Bm1_16095 Bm1_18665
TSP: 
Tsp_10381
SMM: 
Smp_125450 Smp_142620 Smp_149980
NVE: 
NEMVE_v1g199592 NEMVE_v1g40000 NEMVE_v1g87698
HMG: 
100197914 100198482 100212830
TAD: 
TRIADDRAFT_19120 TRIADDRAFT_24913 TRIADDRAFT_25423 TRIADDRAFT_30655 TRIADDRAFT_56641
AQU: 
100633664 100636320
CRE: 
CHLREDRAFT_142791(CYG15)
VCN: 
VOLCADRAFT_61364(cyc2)
MBR: 
MONBRDRAFT_33782 MONBRDRAFT_37136
PFA: 
MAL13P1.301(gc-betA) PF11_0395
PYO: 
PY04459
PKN: 
PKH_111030
TAN: 
TA15475
TVA: 
TVAG_082230 TVAG_162100 TVAG_219680 TVAG_228010 TVAG_383510
TPS: 
THAPSDRAFT_263953
PAT: 
Patl_2382
MFA: 
Mfla_1571
MMB: 
Mmol_0792
MEH: 
M301_0906
BRA: 
BRADO2991
BBT: 
BBta_5176
JAN: 
Jann_1561
MGI: 
Mflv_3576
TER: 
Tery_2417
 » show all
Taxonomy
Reference
1  [PMID:235291]
  Authors
Garbers DL, Suddath JL, Hardman JG.
  Title
Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity.
  Journal
Biochim. Biophys. Acta. 377 (1975) 174-85.
  Organism
Rattus norvegicus [GN:rno], sea urchin
Reference
2  [PMID:4982201]
  Authors
Hardman JG, Sutherland EW.
  Title
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate.
  Journal
J. Biol. Chem. 244 (1969) 6363-70.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-75-5
DBGET integrated database retrieval system