| Entry |
|
|---|
| Name |
aspartate racemase;
D-aspartate racemase;
McyF |
|---|
| Class |
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
 |
|---|
| Sysname |
aspartate racemase |
|---|
| Reaction(IUBMB) |
L-aspartate = D-aspartate [RN:R00491] |
|---|
| Reaction(KEGG) |
R00491
 |
|---|
| Substrate |
L-aspartate [CPD:C00049] |
|---|
| Product |
D-aspartate [CPD:C00402] |
|---|
| Comment |
Also acts, at half the rate, on L-alanine. |
|---|
| Pathway |
PATH: ec00250 Alanine, aspartate and glutamate metabolism |
|---|
| Orthology |
KO: K01779 aspartate racemase |
|---|
| Genes |
ECP: ECP_2853
ECM: EcSMS35_1090
STY: STY4866
STT: t4560
SPT: SPA4330
SEK: SSPA4021
SPQ: SPAB_05674
SEI: SPC_4647
SEC: SC4365(pnl)
SEH: SeHA_C4914
SEE: SNSL254_A4865
SEW: SeSA_A4766
SEA: SeAg_B4841
SED: SeD_A4912
SEG: SG4340
SET: SEN4271
SES: SARI_03065
STM: STM4510
YPE: YPO2758
YPK: y1592
YPM: YP_2405(racX)
YPA: YPA_2085
YPN: YPN_2188
YPG: YpAngola_A0370
YPP: YPDSF_2002
YPS: YPTB2625
YPI: YpsIP31758_1412
YPY: YPK_1521
YPB: YPTS_2720
YEN: YE1289
ECA: ECA1293 ECA1500 ECA1532
PCT: PC1_1171 PC1_1378 PC1_1405
PWA: Pecwa_1778 Pecwa_1803 Pecwa_3160
CKO: CKO_02076 CKO_04217
SPE: Spro_3409
EIC: NT01EI_1000 NT01EI_1274
ETR: ETAE_0921 ETAE_1150
DDA: Dd703_1082 Dd703_1263 Dd703_1302
DDC: Dd586_2632
DZE: Dd1591_2731
XCC: XCC1785(ygeA)
XCB: XC_2451
XCA: xccb100_2480
XCV: XCV1832
XAC: XAC1802(ygeA)
SML: Smlt3366
SMT: Smal_2793
VSP: VS_II0630
VEX: VEA_000098
VFI: VF_1547 VF_A0624(ygeA)
VFM: VFMJ11_1642
VSA: VSAL_I2004
PPR: PBPRA2356
PFL: PFL_2830
PFS: PFLU3010
PCR: Pcryo_0021
ACI: ACIAD0318
ACB: A1S_2202
ABY: ABAYE1354
ABC: ACICU_02402
ABN: AB57_2538
ABB: ABBFA_001264
SDN: Sden_1375 Sden_1468
SFR: Sfri_1897
SAZ: Sama_2886
SSE: Ssed_2728
SPL: Spea_0941
SHL: Shal_0991
SWD: Swoo_1908
SWP: swp_4573
ILO: IL1778
PAT: Patl_0005
MAQ: Maqu_1062
AMC: MADE_03998
PIN: Ping_2098
HCH: HCH_00437
CSA: Csal_0199
MMW: Mmwyl1_3685
AHA: AHA_3590
ASA: ASA_3552
CVI: CV_0113
LHK: LHK_00054
RSO: RSc0212
REU: Reut_A1720
REH: H16_B2421(racX)
RME: Rmet_4003
BMV: BMASAVP1_0100
BML: BMA10229_0324
BMN: BMA10247_A1269
BTE: BTH_II1157
BVI: Bcep1808_2223
BUR: Bcep18194_A5449
BCN: Bcen_5934
BCH: Bcen2424_2143
BCM: Bcenmc03_2161
BCJ: BCAL2215
BAM: Bamb_2180 Bamb_6217 Bamb_6429
BAC: BamMC406_2053 BamMC406_3987 BamMC406_5944 BamMC406_6141
BMU: Bmul_1127
BMJ: BMULJ_02127(racD)
BXE: Bxe_A1530 Bxe_A3003
BPH: Bphy_5638 Bphy_5991
BPY: Bphyt_2599 Bphyt_4701 Bphyt_6736
BGL: bglu_2g03010
BPE: BP0053
BPA: BPP2936
BBR: BB2904
BPT: Bpet2326
BAV: BAV1890
RFR: Rfer_3727
POL: Bpro_4384 Bpro_4755
DAC: Daci_0071 Daci_4503
VAP: Vapar_1547 Vapar_3776
CTT: CtCNB1_0063 CtCNB1_1833 CtCNB1_3775
HHE: HH0075(ygeA)
CJJ: CJJ81176_0120
CJU: C8J_0077
CJD: JJD26997_0092
CFF: CFF8240_1412
CCV: CCV52592_0918 CCV52592_1034 CCV52592_1766
CHA: CHAB381_0452
CCO: CCC13826_1511
CLA: Cla_0734
SDL: Sdel_0053
NAM: NAMH_0865
GBM: Gbem_1222
GEM: GM21_3053
DDS: Ddes_0351 Ddes_1020
DMA: DMR_02200
DSA: Desal_3172
DAL: Dalk_4759
DAT: HRM2_03110(racD1) HRM2_07710(racD2)
ACP: A2cp1_0557
PUB: SAR11_1277(racX)
SMD: Smed_1970
ARA: Arad_2875
AVI: Avi_2787
RET: RHE_CH02763(ypch00952)
REC: RHECIAT_CH0002904
RLE: RL3216(asr)
RLT: Rleg2_2506
RLG: Rleg_2760
RHI: NGR_c19850(asr)
OAN: Oant_0550
BBT: BBta_4741
AZC: AZC_0103
MRD: Mrad2831_4295
MNO: Mnod_2741
CCR: CC_2033 CC_3278
CCS: CCNA_02113 CCNA_03387
CAK: Caul_0902 Caul_3181
PZU: PHZ_c1977 PHZ_c2913
SIL: SPO2662
RDE: RD1_0818
ZMO: ZMO0371 ZMO1158
ZMN: Za10_0168 Za10_0870
NAR: Saro_1847
GDJ: Gdia_0972
RCE: RC1_0431
BAN: BA2223 BA2639 BA5005
BAR: GBAA2223 GBAA2639 GBAA5005
BAA: BA_2726 BA_3158 BA_5425
BAT: BAS2067 BAS2459 BAS4650
BAH: BAMEG_1953 BAMEG_2373 BAMEG_5039
BAI: BAA_2285 BAA_2705 BAA_5018
BCE: BC2177 BC2623 BC4750
BCA: BCE_0308 BCE_2253 BCE_2665 BCE_4895
BCZ: BCZK2006(racD) BCZK2383(asp) BCZK4503
BCR: BCAH187_A2335 BCAH187_A2706 BCAH187_A4889
BCB: BCB4264_A2205 BCB4264_A2663 BCB4264_A4865
BCU: BCAH820_2251 BCAH820_2656 BCAH820_4873
BCG: BCG9842_B0374 BCG9842_B2661 BCG9842_B3120
BCQ: BCQ_2161(racD) BCQ_2504(asp) BCQ_4567
BCX: BCA_2307 BCA_2729 BCA_4878
BCY: Bcer98_1877 Bcer98_3426
BTK: BT9727_2007(racD) BT9727_2422(asp) BT9727_4485
BTL: BALH_1986(racD) BALH_2374(asp) BALH_4328
BWE: BcerKBAB4_2048 BcerKBAB4_2501 BcerKBAB4_4583
BCL: ABC3598(racX)
BAY: RBAM_005490(racX)
BPU: BPUM_1136(racX)
GYM: GYMC10_3594
LSP: Bsph_0277 Bsph_2278
BBE: BBR47_33470(racX) BBR47_45030
PJD: Pjdr2_3256 Pjdr2_3258
LLA: L92665(racD)
LLK: LLKF_2493(racD)
LLC: LACR_2531
LLM: llmg_2504(racD)
SMU: SMU.54
SSA: SSA_0042
LPL: lp_1523(racD)
LPJ: JDM1_1276
LJO: LJ0566
LJF: FI9785_1659(racD)
LAC: LBA0546 LBA1817
LSA: LSA0099(racD)
LSL: LSL_0018(racX)
LDB: Ldb2043(racD)
LBU: LBUL_1890
LBR: LVIS_1499
LCA: LSEI_0224
LCB: LCABL_02130(racD)
LGA: LGAS_1732
LRE: Lreu_0282
LRF: LAR_0270
LHE: lhv_1852
LFE: LAF_0241
LRH: LGG_00258(racD)
LRL: LC705_00249(racD)
PPE: PEPE_0662
OOE: OEOE_1048
CTC: CTC00823
CDF: CD2028(racX) CD2254
CDC: CD196_1898(racX) CD196_2111
CDL: CDR20291_1941(racX) CDR20291_2154
CBE: Cbei_3176
AMT: Amet_4258
AOE: Clos_0547
VPR: Vpar_0296
DSY: DSY4104
DHD: Dhaf_1262
TTE: TTE1724(racX)
CPO: COPRO5265_1255
NTH: Nther_0629
RHA: RHA1_ro00144 RHA1_ro02319 RHA1_ro06664
RER: RER_54750
XCE: Xcel_1886
NCA: Noca_4055
SRO: Sros_4590
FAL: FRAAL2547
KRA: Krad_4072
SEN: SACE_2953(racX) SACE_5069(racX)
BAD: BAD_1087(racD)
ABA: Acid345_4593
RMR: Rmar_2418
CPI: Cpin_3404
FJO: Fjoh_2497
FSU: Fisuc_0545
LBA: Lebu_1754
STR: Sterm_4003
MAR: MAE_38620(mcyF)
NPU: Npun_R6587
AVA: Ava_4838 Ava_C0005
CTS: Ctha_1448
HAU: Haur_4559
TRO: trd_1098(murI)
STI: Sthe_0684
DDR: Deide_3p00370
TLE: Tlet_0908
PMO: Pmob_1573
KOL: Kole_0509
MMP: MMP0739
MBN: Mboo_2031
MPD: MCP_0433
PTO: PTO0149
PHO: PH0670
PAB: PAB0912(racD-1)
PFU: PF0980
TKO: TK0504
TON: TON_0669 TON_0801
TGA: TGAM_1341(racD-1) TGAM_1356(racD-2)
TSI: TSIB_0542
 |
|---|
| Structures |
PDB: 1IU9 1JFL 2DX7 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4626916]
Lamont HC, Staudenbauer WL, Strominger JL.
Partial purification and characterization of an aspartate racemase
from Streptococcus faecalis.
J. Biol. Chem. 247 (1972) 5103-6.
Streptococcus faecalis |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1526977]
Yamauchi T, Choi SY, Okada H, Yohda M, Kumagai H, Esaki N, Soda K.
Properties of aspartate racemase, a pyridoxal
5'-phosphate-independent amino acid racemase.
J. Biol. Chem. 267 (1992) 18361-4.
Streptococcus thermophilus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:12051922]
Liu L, Iwata K, Kita A, Kawarabayasi Y, Yohda M, Miki K.
Crystal structure of aspartate racemase from Pyrococcus horikoshii
OT3 and its implications for molecular mechanism of PLP-independent
racemization.
J. Mol. Biol. 319 (2002) 479-89.
Pyrococcus horikoshii [GN:pho] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:12713441]
Sielaff H, Dittmann E, Tandeau De Marsac N, Bouchier C, Von Dohren
H, Borner T, Schwecke T.
The mcyF gene of the microcystin biosynthetic gene cluster from
Microcystis aeruginosa encodes an aspartate racemase.
Biochem. J. 373 (2003) 909-16.
Microcystis aeruginosa [GN:mar] |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
5 [PMID:15606767]
Yamashita T, Ashiuchi M, Ohnishi K, Kato S, Nagata S, Misono H.
Molecular identification of monomeric aspartate racemase from
Bifidobacterium bifidum.
Eur. J. Biochem. 271 (2004) 4798-803.
Bifidobacterium bifidum
NCBI-GI: 56790013 |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.1.1.13
IUBMB Enzyme Nomenclature: 5.1.1.13
ExPASy - ENZYME nomenclature database: 5.1.1.13
BRENDA, the Enzyme Database: 5.1.1.13
CAS: 37237-56-2 |
|---|
