KEGG   ENZYME: 5.1.2.3Help
Entry
EC 5.1.2.3                  Enzyme                                 
Name 3-hydroxybutyryl-CoA epimerase;
3-hydroxybutyryl coenzyme A epimerase;
3-hydroxyacyl-CoA epimerase
Class Isomerases;
Racemases and epimerases;
Acting on hydroxy acids and derivatives
BRITE hierarchy
Sysname 3-hydroxybutanoyl-CoA 3-epimerase
Reaction(IUBMB) (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA [RN:R03276]
Reaction(KEGG) R03276
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Substrate (S)-3-hydroxybutanoyl-CoA [CPD:C01144]
Product (R)-3-hydroxybutanoyl-CoA [CPD:C03561]
Pathway PATH: ec00071  Fatty acid metabolism
PATH: ec00650  Butanoate metabolism
Orthology KO: K01782  3-hydroxybutyryl-CoA epimerase
Genes TCR: 508981.39 509701.10
LMA: LmjF26.1550
LIF: LinJ26.1560
LBZ: LbrM26_V2.1570
ECO: b2341(fadJ) b3846(fadB)
ECJ: JW2338(yfcX) JW3822(fadB)
ECD: ECDH10B_2504(fadJ) ECDH10B_4035(fadB)
EBW: BWG_2113(fadJ) BWG_3522(fadB)
ECE: Z3604(fadJ) Z5367(fadB)
ECS: ECs3224(fadJ) ECs4774(fadB)
ECF: ECH74115_3484(fadJ) ECH74115_5285(fadB)
ETW: ECSP_3215 ECSP_4899(fadB)
ECG: E2348C_2480(fadJ) E2348C_4158(fadB)
ECC: c2886(fadJ) c4793(fadB)
ECI: UTI89_C2625(fadJ) UTI89_C4431(fadB)
ECP: ECP_2379(fadJ) ECP_4059(fadB)
ECV: APECO1_2611(fadB) APECO1_4225(fadJ)
ECW: EcE24377A_2637(fadJ) EcE24377A_4365(fadB)
ECX: EcHS_A2492(fadJ) EcHS_A4069(fadB)
ECM: EcSMS35_2500(fadJ) EcSMS35_4227(fadB)
ECY: ECSE_2650(fadJ) ECSE_4132(fadB)
ECL: EcolC_1312(fadJ) EcolC_4164(fadB)
ECK: EC55989_2585(fadJ) EC55989_4321(fadB)
ECQ: ECED1_2804(fadJ) ECED1_4548(fadB)
ECR: ECIAI1_2418(fadJ) ECIAI1_4039(fadB)
ECT: ECIAI39_2493(fadJ) ECIAI39_3149(fadB)
ECZ: ECS88_2488(fadJ) ECS88_4294(fadB)
EUM: ECUMN_2680(fadJ) ECUMN_4370(fadB)
ELF: LF82_0614(fadB) LF82_0619(fadJ)
EBL: B21_02226(yfcX) B21_03686(fadB)
EBD: ECBD_1319 ECBD_4179
EBR: ECB_02265(yfcX) ECB_03737(fadB)
EOH: ECO103_2805(yfcX) ECO103_4319(fadB)
EOI: ECO111_3088(yfcX) ECO111_4672(fadB)
EOJ: ECO26_3328(yfcX) ECO26_4741(fadB)
EFE: EFER_0823(fadJ) EFER_3635(fadB)
STY: STY2620(fadJ) STY3577(fadB)
STT: t0476(fadJ) t3315(fadB)
SPT: SPA0476(fadJ) SPA3823(fadB)
SEK: SSPA0440(fadJ) SSPA3560(fadB)
SPQ: SPAB_00579(fadJ) SPAB_04939(fadB)
SEI: SPC_1317(yfcX) SPC_4090(fadB)
SEC: SC2390(fadJ) SC3880(fadB)
SEH: SeHA_C2630(fadJ) SeHA_C4309(fadB)
SEE: SNSL254_A2577(fadJ) SNSL254_A4262(fadB)
SEW: SeSA_A2617(fadJ) SeSA_A4190(fadB)
SEA: SeAg_B2528(fadJ) SeAg_B4213(fadB)
SED: SeD_A2742(fadJ) SeD_A4369(fadB)
SEG: SG2418(fadJ) SG3469(fadB)
SET: SEN2370(fadJ) SEN3777(fadB)
SES: SARI_00511(fadJ) SARI_03676(fadB)
STM: STM2388(fadJ) STM3983(fadB)
YPE: YPO2747(fadJ) YPO3766(fadB)
YPK: y0464(fadB) y1580(fadJ)
YPM: YP_2417(fadJ) YP_3282(fadB)
YPA: YPA_2097(fadJ) YPA_3436(fadB)
YPN: YPN_0198(fadB) YPN_2200(fadJ)
YPG: YpAngola_A0382(fadJ) YpAngola_A1912(fadB)
YPP: YPDSF_2013(fadJ) YPDSF_3386(fadB)
YPS: YPTB0267(fadB) YPTB2636(fadJ)
YPI: YpsIP31758_0283(fadB) YpsIP31758_1400(fadJ)
YPY: YPK_1509(fadJ) YPK_3933(fadB)
YPB: YPTS_0283(fadB) YPTS_2733(fadJ)
YEN: YE0268(fadB) YE1277(fadJ)
SFL: SF2419(fadJ) SF3922(fadB)
SFX: S2554(fadJ) S3830(fadB)
SFV: SFV_2409(fadJ) SFV_3654(fadB)
SSN: SSON_2397(fadJ) SSON_4019(fadB)
SBO: SBO_2379(fadJ)
SBC: SbBS512_E2721(fadJ) SbBS512_E4316(fadB)
SDY: SDY_2542(fadJ) SDY_3899(fadB)
ECA: ECA0208(fadB) ECA3078(fadJ)
PCT: PC1_2821 PC1_4044
PWA: Pecwa_1444 Pecwa_4234
ETA: ETA_02460(fadB) ETA_11500(fadJ)
PLU: plu3200(fadJ) plu4402(fadB)
PAY: PAU_01417(fadJ) PAU_03873(fadB)
ENT: Ent638_2881(fadJ) Ent638_3949(fadB)
ESA: ESA_00882(fadJ) ESA_03714(fadB)
CTU: Ctu_02770(fadB) Ctu_29620(fadJ)
KPN: KPN_02723(fadJ) KPN_04340(fadB)
KPE: KPK_1416(fadJ) KPK_5333(fadB)
KPU: KP1_0203(fadB) KP1_3973(yfcX)
CKO: CKO_00188(fadB) CKO_00449(fadJ)
SPE: Spro_0261(fadB) Spro_3378(fadJ)
PMR: PMI1807(fadJ) PMI3550(fadB)
DDA: Dd703_2597 Dd703_3747
DDC: Dd586_0200 Dd586_2799
DZE: Dd1591_1341 Dd1591_3901
HAP: HAPS_0676(fadJ)
APL: APL_0888(fadJ)
APJ: APJL_0900(fadJ)
APA: APP7_0947
XCC: XCC1266(fadB)
XCB: XC_2975
XCA: xccb100_3037(fadB3)
XCV: XCV1369(fadB)
XAC: XAC1318(fadB)
XOO: XOO1848(fadB)
XOM: XOO_1744
XOP: PXO_01709
SML: Smlt3556
SMT: Smal_2982
VCH: VC1047(fadJ) VC2758(fadB)
VCO: VC0395_A0565(fadJ) VC0395_A2534(fadB)
VCM: VCM66_1002(yfcX) VCM66_2678(fadB)
VCJ: VCD_001454 VCD_003295
VVU: VV1_0981(fadB) VV1_1976(fadJ)
VVY: VV0029(fadB) VV2440(fadJ)
VPA: VP0030(fadB) VP2208(fadJ)
VHA: VIBHAR_00460(fadB) VIBHAR_03120(fadJ)
VSP: VS_0041(fadB) VS_0865(fadJ)
VEX: VEA_001988 VEA_002857
VFI: VF_0025(fadB) VF_1810(fadJ)
VFM: VFMJ11_0024(fadB) VFMJ11_1943(fadJ)
VSA: VSAL_I2974(fadB)
PPR: PBPRA0064(fadB) PBPRA0962(fadJ)
PAE: PA3014(fadB)
PAU: PA14_25080(fadB)
PAP: PSPA7_2145(fadB) PSPA7_3568
PAG: PLES_20481(fadB) PLES_35921
PPU: PP_2136(fadB)
PPF: Pput_3606(fadB)
PPG: PputGB1_1676(fadB)
PPW: PputW619_1652(fadB)
PST: PSPTO_3517(fadB)
PSB: Psyr_3290(fadB)
PSP: PSPPH_3210(fadB)
PFL: PFL_1940(fadB)
PFO: Pfl01_1740 Pfl01_3879(fadB)
PFS: PFLU1553(fadB) PFLU4661
PEN: PSEEN3728(fadB)
PMY: Pmen_1580(fadB)
PSA: PST_1726(fadB)
AVN: Avin_14440(fadB1)
PAR: Psyc_1399 Psyc_1934(fadB)
PCR: Pcryo_2227(fadB)
PRW: PsycPRwf_2100(fadB)
ACI: ACIAD0335(fadB) ACIAD2989
ABM: ABSDF0590 ABSDF3220(fadB)
ABY: ABAYE0628 ABAYE3470(fadB)
ABC: ACICU_00322(fadB)
ABN: AB57_0387(fadB)
ABB: ABBFA_003230(fadB)
SON: SO_0021(fadB) SO_3088(fadJ)
SDN: Sden_0015(fadB) Sden_1530(fadJ)
SFR: Sfri_0013(fadB) Sfri_2676(fadJ)
SAZ: Sama_0032(fadB) Sama_2167(fadJ)
SBL: Sbal_0021(fadB) Sbal_2760(fadJ)
SBM: Shew185_0016(fadB) Shew185_2780(fadJ)
SBN: Sbal195_0020(fadB) Sbal195_2855(fadJ)
SBP: Sbal223_0020(fadB) Sbal223_1598(fadJ)
SLO: Shew_0019(fadB) Shew_2425(fadJ)
SPC: Sputcn32_0013(fadB) Sputcn32_2459(fadJ)
SSE: Ssed_0023(fadB) Ssed_1629(fadJ)
SPL: Spea_0018(fadB) Spea_2598(fadJ)
SHE: Shewmr4_0018(fadB) Shewmr4_1408(fadJ)
SHM: Shewmr7_0016(fadB) Shewmr7_1473(fadJ)
SHN: Shewana3_0024(fadB) Shewana3_1461(fadJ)
SHW: Sputw3181_0013(fadB) Sputw3181_1549(fadJ)
SHL: Shal_0016(fadB) Shal_2670(fadJ)
SWD: Swoo_0021(fadB) Swoo_3026(fadJ)
SWP: swp_0035(fadB) swp_3139(fadJ)
ILO: IL0011(fadB) IL0993(fadJ)
CPS: CPS_0393(fadB) CPS_3156(fadJ)
PHA: PSHAa0011(fadB) PSHAa0967(fadJ)
PAT: Patl_0201(fadB) Patl_1664(fadJ)
SDE: Sde_1605(fadB)
MAQ: Maqu_1144(fadB)
AMC: MADE_02700(fadJ) MADE_03736(fadB)
PIN: Ping_2604
TTU: TERTU_1620(fadB)
CBU: CBU_0576(yfcX)
CBS: COXBURSA331_A0690
CBD: CBUD_1487
CBG: CbuG_1422(yfcX)
CBC: CbuK_1262(yfcX)
FTU: FTT_1530(fadB)
FTF: FTF1530(fadB)
NOC: Noc_0826 Noc_1733(fadJ)
AEH: Mlg_2111
HCH: HCH_04756(fadB)
CSA: Csal_2393(fadB)
ABO: ABO_1566(fadB) ABO_1652(fadB)
MMW: Mmwyl1_1578(fadB)
AHA: AHA_0139(fadB) AHA_2154(fadJ)
ASA: ASA_2145(fadJ) ASA_4250(fadB)
KKO: Kkor_0013 Kkor_1978
CVI: CV_2720(fadB)
RPI: Rpic_4929
RPF: Rpic12D_3852
BMA: BMA0198
BMV: BMASAVP1_A2747 BMASAVP1_A3485
BML: BMA10229_A1822 BMA10229_A2331
BMN: BMA10247_2411 BMA10247_2730
BPS: BPSL0063 BPSL0649
BPM: BURPS1710b_0287(fadB) BURPS1710b_0858(fadB)
BPL: BURPS1106A_0073 BURPS1106A_0696
BPD: BURPS668_0075 BURPS668_0681
BPR: GBP346_A0608 GBP346_A4262
BTE: BTH_I0062 BTH_I0565
BXE: Bxe_C0280
BPT: Bpet3411(fadB2)
CTT: CtCNB1_1297
AZO: azo0465(fadB1)
DAR: Daro_2350(fadB)
ADE: Adeh_0408(fadJ)
ACP: A2cp1_0437
AFW: Anae109_4162(fadJ)
ANK: AnaeK_0436(fadJ)
MXA: MXAN_5371(fadJ) MXAN_6987(fadJ)
SCL: sce0048(fadJ)
HOH: Hoch_1658 Hoch_1660 Hoch_3456
MLO: mlr5629
MES: Meso_0021 Meso_1524
PLA: Plav_0465
SME: SMc02227(fadB)
SMD: Smed_0144
ATU: Atu0503(fadB)
ATC: AGR_C_888
ARA: Arad_0816(fadB2)
AVI: Avi_0597(fadB)
RET: RHE_CH00559(fadB2)
REC: RHECIAT_CH0000632(fadB2)
RLE: RL0594
RLT: Rleg2_0216
RLG: Rleg_0244
RHI: NGR_c01670(fadB)
BME: BMEII0497
BMI: BMEA_B0772
BMF: BAB2_0444
BMB: BruAb2_0439(fadB)
BMC: BAbS19_II04190
BMS: BRA0793(fadB)
BMT: BSUIS_B0785
BOV: BOV_A0744(fadB)
BCS: BCAN_B0807(fadJ)
BMR: BMI_II787(fadB)
OAN: Oant_4031
BJA: blr1160(fadB) blr2428
RPA: RPA0818
RPB: RPB_4604
RPC: RPC_0735
RPD: RPD_0807
RPE: RPE_0674
RPT: Rpal_0887
NWI: Nwi_2993
OCA: OCAR_5223
MEX: Mext_3241
MEA: Mex_1p3452
MDI: METDI4031
MRD: Mrad2831_0006
MET: M446_3281
MPO: Mpop_3437
MCH: Mchl_3565
MNO: Mnod_5242
MSL: Msil_1395(fadB)
CCR: CC_0076
CCS: CCNA_00074
CAK: Caul_0125
SIL: SPO2920(fabJ-1)
SIT: TM1040_1562
RSP: RSP_2196
RSH: Rsph17029_0871
RSQ: Rsph17025_2296
RSK: RSKD131_0512
JAN: Jann_2977
RDE: RD1_3973(fadJ)
PDE: Pden_2871
DSH: Dshi_0835(fadJ)
MMR: Mmar10_0543
HNE: HNE_0672
HBA: Hbal_0931
RCE: RC1_1743(fadJ)
MTU: Rv0860(fadB)
MTC: MT0883
MRA: MRA_0868(fadB)
MTF: TBFG_10877
MTB: TBMG_03130(TBMG_03130.1)
MBO: Mb0883(fadB)
MBB: BCG_0912(fadB)
MBT: JTY_0882(fadB)
MLE: ML2161(fadB)
MLB: MLBr_02161(fadB)
MPA: MAP0790(fadB_1) MAP1715(fadB_2)
MAV: MAV_0981 MAV_2701
MUL: MUL_0295(fadB)
MVA: Mvan_5066
MGI: Mflv_1692
MAB: MAB_0851
MMI: MMAR_4676(fadB)
CJK: jk0159(fadB1)
CUR: cur_0178(fadB1)
CKP: ckrop_0257(fadB1)
NFA: nfa2860(fadB)
RHA: RHA1_ro00407 RHA1_ro04205(fadB1) RHA1_ro06116(fadB2)
     RHA1_ro06852
RER: RER_03810(fadB)
ROP: ROP_41320(fadB)
GBR: Gbro_4503
SCO: SCO6732(SC5F2A.15) SCO6789(SC6A5.38)
SMA: SAV_1680(fadB1)
SGR: SGR_993
RSA: RSal33209_3440
KRH: KRH_20960(fadB)
BFA: Bfae_30150
FRA: Francci3_1329
FRE: Franean1_2944
FAL: FRAAL2096
SEN: SACE_1823 SACE_6362(fadB)
SVI: Svir_30240
AMI: Amir_4372 Amir_5669
CAI: Caci_5261
RXY: Rxyl_2453
SRU: SRU_1459(yfcX)
RMR: Rmar_1469
GAU: GAU_2856(fadJ)
RBA: RB1092(faoA)
DRA: DR_1487
PIS: Pisl_1438
Taxonomy
Structures PDB: 1WDK  1WDL  1WDM  2D3T  
Reference
  Authors
  Title

  Journal
 1
Stern, J.R., del Campillo, A. and Lehninger, A.L.
Enzymatic racemization of beta-hydroxybutyryl-S-CoA and the
stereospecificity of enzymes of the fatty acid cycle.
J. Am. Chem. Soc. 77 (1955) 1073-1074.
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:13276396]
WAKIL SJ.
D(-)beta-Hydroxybutyryl CoA dehydrogenase.
Biochim. Biophys. Acta. 18 (1955) 314-5.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 5.1.2.3
IUBMB Enzyme Nomenclature: 5.1.2.3
ExPASy - ENZYME nomenclature database: 5.1.2.3
BRENDA, the Enzyme Database: 5.1.2.3
CAS: 9024-21-9
DBGET integrated database retrieval system