KEGG   ENZYME: 5.1.3.14Help
Entry
EC 5.1.3.14                 Enzyme                                 
Name UDP-N-acetylglucosamine 2-epimerase;
UDP-N-acetylglucosamine 2'-epimerase;
uridine diphosphoacetylglucosamine 2'-epimerase;
uridine diphospho-N-acetylglucosamine 2'-epimerase;
uridine diphosphate-N-acetylglucosamine-2'-epimerase
Class Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
BRITE hierarchy
Sysname UDP-N-acetyl-D-glucosamine 2-epimerase
Reaction(IUBMB) UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine [RN:R00420]
Reaction(KEGG) R00420;
(other) R00414 R02707
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Substrate UDP-N-acetyl-D-glucosamine [CPD:C00043]
Product UDP-N-acetyl-D-mannosamine [CPD:C01170]
Comment The enzyme hydrolyses the product to UDP and N-acetyl-D-mannosamine.
Pathway PATH: ec00520  Amino sugar and nucleotide sugar metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01791  UDP-N-acetylglucosamine 2-epimerase
KO: K12409  bifunctional UDP-N-acetylglucosamine
            2-epimerase/N-acetylmannosamine kinase
Genes HSA: 10020(GNE)
PTR: 465094(GNE)
MCC: 693525(GNE)
MMU: 50798(Gne)
RNO: 114711(Gne)
CFA: 481607(GNE)
BTA: 782201(GNE)
ECB: 100067216
MDO: 100017383
OAA: 100075502
GGA: 427285(GNE)
TGU: 100226686
XTR: 780185
DRE: 393857(gne)
BFO: BRAFLDRAFT_124939
SPU: 590539
OLU: OSTLU_25793
ECO: b3786(rffE)
ECJ: JW5600(rffE)
ECD: ECDH10B_3975(rffE)
EBW: BWG_3468(rffE)
ECE: Z5297(wecB)
ECS: ECs4719
ECF: ECH74115_5219
ETW: ECSP_4834(rffE)
ECG: E2348C_4087(rffE)
ECC: c4706(wecB)
ECI: UTI89_C3370(neuC) UTI89_C4342(rffE)
ECP: ECP_3977
ECV: APECO1_26882(rffE) APECO1_3473(neuC)
ECW: EcE24377A_4297
ECX: EcHS_A4003
ECM: EcSMS35_3230(neuC) EcSMS35_4150
ECY: ECSE_4069
ECL: EcolC_4217
ECK: EC55989_2293 EC55989_4258(rffE)
ECQ: ECED1_4471(rffE)
ECR: ECIAI1_3973(rffE)
ECT: ECIAI39_3001(rffE) ECIAI39_3441(neuC)
ECZ: ECS88_3328(neuC) ECS88_4208(rffE)
EUM: ECUMN_4311(rffE)
ELF: LF82_1859(rffE)
EBL: B21_03613(rffE)
EBD: ECBD_4253
EBR: ECB_03664(wecB)
EOH: ECO103_4378(rffE)
EOI: ECO111_4612(rffE)
EOJ: ECO26_2943(fnl3) ECO26_4800(rffE)
EFE: EFER_3718(rffE)
STY: STY3635(wecB)
STT: t3377(wecB)
SPT: SPA3760(wecB)
SEK: SSPA3504
SPQ: SPAB_04865
SEI: SPC_4034(wecB)
SEC: SC3825(wecB)
SEH: SeHA_C4249
SEE: SNSL254_A4200
SEW: SeSA_A4131
SEA: SeAg_B4146
SED: SeD_A4308
SEG: SG3523(wecB)
SET: SEN3725(wecB)
SES: SARI_00800 SARI_03733
STM: STM3920(wecB)
YPE: YPO3864(nfrC)
YPK: y0364(wecB)
YPM: YP_3181(rffE)
YPA: YPA_0154
YPN: YPN_0099
YPG: YpAngola_A0514
YPP: YPDSF_3482
YPS: YPTB0170(rffE)
YPI: YpsIP31758_0184
YPY: YPK_4031
YPB: YPTS_0182
YEN: YE0171(nfrC)
SFL: SF3860(wecB)
SFX: S3900(wecB)
SFV: SFV_3718(wecB)
SSN: SSON_3958(wecB)
SBO: SBO_3797(wecB)
SBC: SbBS512_E4135
SDY: SDY_3962(wecB)
ECA: ECA4208(wecB)
PCT: PC1_4008
PWA: Pecwa_4200
ETA: ETA_01990(wecB)
PLU: plu4660(wecB)
PAY: PAU_04140(wecB)
SGL: SG2383
ENT: Ent638_4000
ESA: ESA_03772
CTU: Ctu_02220(wecB) Ctu_27290
KPN: KPN_04286(wecB)
KPE: KPK_5393
KPU: KP1_0148(wecB)
CKO: CKO_00127
SPE: Spro_0163
PMR: PMI3318(rffE)
EIC: NT01EI_0092 NT01EI_1318
ETR: ETAE_0103(wecB) ETAE_1209(neuC)
DDA: Dd703_0205
DDC: Dd586_0658 Dd586_3897
DZE: Dd1591_0160
HDU: HD1843(wecB)
HAP: HAPS_1768(wecB)
APL: APL_1552(wecB)
APJ: APJL_1580(wecB)
APA: APP7_1614
XAC: XAC0044(bplD)
SML: Smlt0710(wecB)
SMT: Smal_0565
VCH: VC0917
VCO: VC0395_A0441(wecB)
VCM: VCM66_0874(wecB)
VCJ: VCD_003417
VVU: VV1_0780 VV1_0807
VVY: VV0341
VHA: VIBHAR_00689
VSA: VSAL_I3013(neuC)
PAU: PA14_23370(orfK)
PPU: PP_1811(wecB)
PPG: PputGB1_1375 PputGB1_1391
PPW: PputW619_2931
PST: PSPTO_1196
PSB: Psyr_1032
PSP: PSPPH_1083
PFL: PFL_3595 PFL_5107
PEN: PSEEN1502 PSEEN2475 PSEEN2963(wecB)
PMY: Pmen_1709 Pmen_1873
ACI: ACIAD1175(wecB)
ACB: A1S_2489 A1S_2897
ABY: ABAYE0969(wecB)
ABC: ACICU_02700
ABN: AB57_2933
ABB: ABBFA_000956
SAZ: Sama_2261 Sama_2332
SBL: Sbal_0067
SSE: Ssed_2966
CPS: CPS_0308
PHA: PSHAa0466(rffE)
PIN: Ping_0431 Ping_0791
CBU: CBU_0842(wecB)
CBS: COXBURSA331_A1108
CBD: CBUD_0907
CBG: CbuG_1159(wecB)
CBC: CbuK_0710(wecB)
NOC: Noc_1976
AEH: Mlg_0109
MMW: Mmwyl1_0801
ASA: ASA_1442(wecB)
KKO: Kkor_0919
NMA: NMA0199
CVI: CV_4020(wecB) CV_4033(neuC)
LHK: LHK_01421
RSO: RSp0510(epsC2) RSp1017(epsC)
RPI: Rpic_4693
RPF: Rpic12D_3616
REU: Reut_B4950
BPS: BPSS2016(wecB)
BPM: BURPS1710b_A1131
BPL: BURPS1106A_A2748
BPD: BURPS668_A2901
BTE: BTH_II0340(wecB)
BVI: Bcep1808_0810 Bcep1808_3862 Bcep1808_4142
BUR: Bcep18194_A3974 Bcep18194_A4466
BCN: Bcen_0854
BCH: Bcen2424_1335
BCM: Bcenmc03_1316
BCJ: BCAL1328(wecB)
BAM: Bamb_5473
BAC: BamMC406_3620 BamMC406_3695
BXE: Bxe_A3733 Bxe_B0648
BPY: Bphyt_0888 Bphyt_4321
BPT: Bpet4831
RFR: Rfer_0663
DAC: Daci_2945
DIA: Dtpsy_2526
CTT: CtCNB1_4217
MMS: mma_2257(wecB1) mma_2283(wecB2) mma_2625(wecB3)
LCH: Lcho_0642 Lcho_1385
NEU: NE0486(rffE) NE2249(wbpI)
NET: Neut_0619
NMU: Nmul_A0259
EBA: ebA4257(wbpI) ebA5890
AZO: azo3278(mnaA)
DAR: Daro_1265 Daro_2402
TMZ: Tmz1t_1123
TBD: Tbd_0286
APP: CAP2UW1_0114 CAP2UW1_1416
HHE: HH0082
TDN: Suden_0597
CJE: Cj1328(neuC2)
CHA: CHAB381_1479
NIS: NIS_1259(wecB)
GSU: GSU2243 GSU2245
GME: Gmet_1489 Gmet_1504
GBM: Gbem_1623 Gbem_2378
GEO: Geob_1459 Geob_2117 Geob_2136
GEM: GM21_1841 GM21_3510
PPD: Ppro_2450
DVM: DvMF_2638
DDS: Ddes_1015
DSA: Desal_3655
BBA: Bd1695(capG)
DAT: HRM2_23090(wecB)
ADE: Adeh_2771 Adeh_4176 Adeh_4279 Adeh_4302
ACP: A2cp1_4329 A2cp1_4456
AFW: Anae109_1410
ANK: AnaeK_4307 AnaeK_4437
MXA: MXAN_1101
SCL: sce2486(mnaA)
SAT: SYN_02683
SFU: Sfum_3330
MES: Meso_3697
ARA: Arad_4847
RPC: RPC_4203
RPD: RPD_0749 RPD_2723
NHA: Nham_3043
XAU: Xaut_1736
AZC: AZC_3215
MEA: Mex_1p4260
MET: M446_3311
MNO: Mnod_2549 Mnod_4309
ZMN: Za10_1869
NAR: Saro_3149
SAL: Sala_1590
SWI: Swit_4666
ELI: ELI_13265
RRU: Rru_A1493 Rru_A2740
MAG: amb0102
MGM: Mmc1_0561 Mmc1_0587
BSU: BSU35660(mnaA)
BAN: BA5433 BA5509
BAR: GBAA5433 GBAA5509
BAA: BA_0286
BAT: BAS5048 BAS5117
BAH: BAMEG_5483 BAMEG_5555
BAI: BAA_5461 BAA_5536
BCE: BC5201
BCA: BCE_5307
BCZ: BCZK4893(mnaA) BCZK4964(mnaA)
BCR: BCAH187_A5365 BCAH187_A5442
BCB: BCB4264_A5320
BCU: BCAH820_5289 BCAH820_5359
BCG: BCG9842_B5639
BCQ: BCQ_5021(mnaA)
BCX: BCA_5329
BCY: Bcer98_3744
BTK: BT9727_4878
BTL: BALH_4693
BWE: BcerKBAB4_4993
BLI: BL02459(mnaA)
BLD: BLi03812(yvyH)
BAY: RBAM_032810(mnaA)
BPU: BPUM_3218(mnaA)
GTN: GTNG_3104
GWC: GWCH70_3132
GYM: GYMC10_5915
AFL: Aflv_2711
SAU: SA0150(capG) SA0159(capP) SA1913(mnaA)
SAV: SAV0155(capG) SAV0164(capP) SAV2111(mnaA)
SAW: SAHV_0154(capG) SAHV_0163(capP) SAHV_2095(mnaA)
SAM: MW0130(cap8G) MW0139(cap8P) MW2035(mnaA)
SAR: SAR0157(capG) SAR0166(capP) SAR2199(mnaA)
SAS: SAS0130 SAS0139 SAS2014
SAC: SACOL0142(cap5G) SACOL0151(cap5P) SACOL2103
SAB: SAB0096(capG) SAB0105(capP) SAB1995c(mnaA)
SAA: SAUSA300_0158(cap5G) SAUSA300_0167(cap5P) SAUSA300_2065
SAX: USA300HOU_0178(cap5P) USA300HOU_2101(mnaA)
SAO: SAOUHSC_00120 SAOUHSC_00129 SAOUHSC_02352
SAJ: SaurJH9_0141 SaurJH9_0150 SaurJH9_2147
SAH: SaurJH1_0146 SaurJH1_0155 SaurJH1_2185
SAE: NWMN_0101(capG) NWMN_0110(capP) NWMN_2015(mnaA)
SAD: SAAV_0123(cap5G) SAAV_0132(cap5P) SAAV_2166
SEP: SE1708
SER: SERP1717
SHA: SH0394(capG) SH0924(mnaA)
SSP: SSP0773
SCA: Sca_1614(mnaA)
LMO: lmo2537
LMF: LMOf2365_2510
LMH: LMHCC_0060
LMC: Lm4b_02506
LIN: lin2681
LWE: lwe2486
LSP: Bsph_1008
ESI: Exig_0808 Exig_2686
EAT: EAT1b_1061 EAT1b_1193
MCL: MCCL_1764(mnaA)
BBE: BBR47_54670(mnaA)
PJD: Pjdr2_5827
AAC: Aaci_2766
LLA: L98310(ymjF)
LLK: LLKF_0285(agsE) LLKF_1332(ymjF)
SPN: SP_0357 SP_0360
SPX: SPG_0324(cpsK)
SPV: SPH_0465
SNT: SPT_0402
SAG: SAG1160(neuC)
SAN: gbs1235(neuC)
SAK: SAK_1249(neuC)
SMU: SMU.1437(epsC)
SSA: SSA_0178(epsC)
SSU: SSU05_0579
SSV: SSU98_0583
SSB: SSUBM407_1279(neuC)
SSI: SSU0536(neuC)
SSS: SSUSC84_0518(neuC)
SUB: SUB1029(mnaA)
LPL: lp_1173
LPJ: JDM1_1015
LJO: LJ1598
LJF: FI9785_667(wecB)
LAC: LBA0620 LBA1720
LSA: LSA1520(mnaA)
LSL: LSL_1276(wecB)
LDB: Ldb0553
LBU: LBUL_0493
LBR: LVIS_1574
LGA: LGAS_0697
LRE: Lreu_0312 Lreu_1389
LRF: LAR_0301 LAR_1308
LHE: lhv_0652
LRH: LGG_01992
LRL: LC705_01998(mnaA)
PPE: PEPE_0597
EFA: EF2917
CAC: CAC2874 CAC3064
CPE: CPE2196
CPF: CPF_2461(mnaA)
CPR: CPR_2171
CTC: CTC00311
CNO: NT01CX_0539 NT01CX_1526 NT01CX_1785
CTH: Cthe_2601 Cthe_2640
CDF: CD1033(mnaA)
CDC: CD196_0909(mnaA)
CDL: CDR20291_0889(mnaA)
CBO: CBO0148(mnaA)
CBA: CLB_0184(mnaA)
CBH: CLC_0196(mnaA)
CBY: CLM_0192(mnaA)
CBL: CLK_3323(mnaA)
CBK: CLL_A0489
CBB: CLD_0637(mnaA)
CBI: CLJ_B0187(mnaA)
CBT: CLH_0481
CBF: CLI_0203(mnaA)
CBE: Cbei_0410
CKL: CKL_3699(epsC)
CKR: CKR_3264
AMT: Amet_0207 Amet_0343
AOE: Clos_2569
STH: STH82
SWO: Swol_0184 Swol_0728
VPR: Vpar_1541
ATE: Athe_1946
DSY: DSY4924
DHD: Dhaf_4822
DRM: Dred_3031 Dred_3159
DAE: Dtox_4174
PTH: PTH_0384(wecB) PTH_2821(wecB)
DAU: Daud_2146
HMO: HM1_1094
FMA: FMG_0129 FMG_0502
EEL: EUBELI_00249
TTE: TTE0155(wecB)
CHY: CHY_2554
MTA: Moth_2387
ADG: Adeg_0074
CSC: Csac_1006
CPO: COPRO5265_0718
NTH: Nther_2855
HOR: Hore_17900
ACL: ACL_1039(wecB1) ACL_1043(wecB2)
MMC: Mmcs_1315
MKM: Mkms_1332
MJL: Mjls_1351
CGT: cgR_0434
CAR: cauri_1789(wecB)
SGR: SGR_403 SGR_4948
LXX: Lxx05070(wbjD) Lxx14026 Lxx21100(wecB)
KRH: KRH_12670
MLU: Mlut_09080
BCV: Bcav_1196
BFA: Bfae_20950 Bfae_27960
KSE: Ksed_18640 Ksed_26840
PAC: PPA0148
SRO: Sros_0374
FRA: Francci3_1308
FRE: Franean1_0381 Franean1_2163
FAL: FRAAL2057(rffE) FRAAL2071
ACE: Acel_0638
KRA: Krad_2936
AMI: Amir_1001
CAI: Caci_7641
RXY: Rxyl_2626
ELE: Elen_0637 Elen_1601 Elen_2442
ABA: Acid345_1025 Acid345_3306
SUS: Acid_7476
BTH: BT_0383 BT_0601 BT_1202 BT_1203 BT_2944
BFR: BF1100 BF1108 BF1844.1 BF2569.1 BF3656 BF4509
BFS: BF0744 BF1910(wcgT) BF4303
BVU: BVU_0686 BVU_0692 BVU_2946 BVU_3351
PGI: PG0120(epsC)
PGN: PGN_0234
PDI: BDI_0043 BDI_0574 BDI_1577 BDI_3833
CHU: CHU_2775(wecB)
DFE: Dfer_4791
CPI: Cpin_1086 Cpin_4706 Cpin_4750
FJO: Fjoh_0304 Fjoh_1039
FPS: FP1255(neuC)
COC: Coch_0699 Coch_1112
FSU: Fisuc_2695
OTE: Oter_2768
GAU: GAU_0584(wecB) GAU_0868(wecB)
RBA: RB9169(wecB)
TAI: Taci_0940
SYN: slr0624
SYW: SYNW1830(nfrC)
SYC: syc0969_c(nfrC)
SYF: Synpcc7942_0552
SYD: Syncc9605_0638
SYE: Syncc9902_1723
SYG: sync_0169 sync_2159
SYR: SynRCC307_0714(nfrC)
SYX: SynWH7803_1840(nfrC)
SYP: SYNPCC7002_A1214
CYA: CYA_0107 CYA_0674
CYB: CYB_2112
TEL: tll2040
MAR: MAE_05870
CYT: cce_3663(wecB)
CYP: PCC8801_0463
CYC: PCC7424_3438
CYN: Cyan7425_1542
CYH: Cyan8802_0477
GVI: glr0701
ANA: all2497
NPU: Npun_R2505
AVA: Ava_0429
PMT: PMT1312(nfrC)
PMF: P9303_01091 P9303_06751(wecB)
PME: NATL1_08581(wecB) NATL1_08731
TER: Tery_2401
AMR: AM1_3118(wecB)
PPH: Ppha_2796
CTS: Ctha_0793
RRS: RoseRS_1131 RoseRS_4430
RCA: Rcas_3971
CAU: Caur_3777
CAG: Cagg_0816
CHL: Chy400_4079
DRA: DR_1561
DGE: Dgeo_1294
DDR: Deide_11860
TTH: TTC0948
TTJ: TTHA1314
SAF: SULAZ_0353
TMA: TM0610 TM1034
TPT: Tpet_0300 Tpet_0308 Tpet_1716
TLE: Tlet_0885 Tlet_1207
TRQ: TRQ2_0326 TRQ2_1774
TNA: CTN_1532
TNP: Tnap_0392 Tnap_0427 Tnap_1730
TME: Tmel_0366 Tmel_0815
TAF: THA_937
FNO: Fnod_0229 Fnod_0568
PMO: Pmob_0123 Pmob_0933 Pmob_1284 Pmob_1288
KOL: Kole_1361 Kole_1631
DTH: DICTH_1307
DTU: Dtur_1413
TYE: THEYE_A0499
MJA: MJ1504
MFE: Mefer_0902
MVU: Metvu_0880
MMP: MMP0357 MMP0705(wbpI)
MMQ: MmarC5_0504 MmarC5_0871
MMX: MmarC6_0179
MMZ: MmarC7_1732
MAE: Maeo_0423 Maeo_0485
MVN: Mevan_0198 Mevan_1583
MBA: Mbar_A0052 Mbar_A2140
MMA: MM_1170
MBU: Mbur_1587 Mbur_2022
MTP: Mthe_1235
MHU: Mhun_0382 Mhun_0396
MEM: Memar_1595 Memar_1605 Memar_2303 Memar_2395
MPL: Mpal_0345 Mpal_0611
MPD: MCP_0866
MTH: MTH837
MST: Msp_0217
MSI: Msm_0853
HMA: pNG7011(wecB)
HUT: Huta_1062
HMU: Hmuk_0086 Hmuk_2022
PHO: PH1617
PAB: PAB0379(wlbD)
PFU: PF0794 PF1630
TKO: TK1230
TON: TON_0501
TSI: TSIB_1920 TSIB_2024
RCI: RCIX1930(wecB)
TPE: Tpen_1715
KCR: Kcr_1306
Taxonomy
Structures PDB: 1F6D  1O6C  1V4V  1VGV  3BEO  3DZC  3EO3  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4770741]
Kikuchi K, Tsuiki S.
Purification and properties of UDP-N-acetylglucosamine 2'-epimerase
from rat liver.
Biochim. Biophys. Acta. 327 (1973) 193-206.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 5.1.3.14
IUBMB Enzyme Nomenclature: 5.1.3.14
ExPASy - ENZYME nomenclature database: 5.1.3.14
BRENDA, the Enzyme Database: 5.1.3.14
CAS: 9037-71-2
DBGET integrated database retrieval system