| Entry |
|
|---|
| Name |
L-ribulose-5-phosphate 4-epimerase;
phosphoribulose isomerase;
ribulose phosphate 4-epimerase;
L-ribulose-phosphate 4-epimerase;
L-ribulose 5-phosphate 4-epimerase;
AraD;
L-Ru5P |
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| Class |
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
 |
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| Sysname |
L-ribulose-5-phosphate 4-epimerase |
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| Reaction(IUBMB) |
L-ribulose 5-phosphate = D-xylulose 5-phosphate [RN:R05850] |
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| Reaction(KEGG) |
R05850
 |
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| Substrate |
L-ribulose 5-phosphate [CPD:C01101] |
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| Product |
D-xylulose 5-phosphate [CPD:C00231] |
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| Comment |
Requires a divalent cation for activity. |
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| Pathway |
PATH: ec00040 Pentose and glucuronate interconversions
PATH: ec00053 Ascorbate and aldarate metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01786 L-ribulose-5-phosphate 4-epimerase
KO: K03077 L-ribulose-5-phosphate 4-epimerase
KO: K03080 L-ribulose-5-phosphate 4-epimerase |
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| Genes |
ECO: b0061(araD) b3583(yiaS) b4198(ulaF)
ECJ: JW0060(araD) JW3555(sgbE) JW4156(ulaF)
ECD: ECDH10B_3764(sgbE) ECDH10B_4393(sgaE)
EBW: BWG_3273(sgbE)
ECE: Z0069(araD) Z5807(sgaE)
ECS: ECs0065(araD) ECs5174(sgaE)
ECF: ECH74115_0066(araD) ECH74115_5714(sgaE)
ETW: ECSP_0065(araD) ECSP_5298(ulaF)
ECG: E2348C_0062(araD) E2348C_3836(sgbE)
ECC: c0073(araD) c4406(sgbE) c5288(sgaE)
ECI: UTI89_C0066(araD) UTI89_C4127(sgbE) UTI89_C4798(sgaE)
ECP: ECP_0062(araD) ECP_3688(sgbE) ECP_4443
ECV: APECO1_1923(araD) APECO1_2194(sgaE)
ECW: EcE24377A_0063(araD) EcE24377A_4080(sgbE) EcE24377A_4759(sgaE)
ECX: EcHS_A0065(araD) EcHS_A3787(sgbE) EcHS_A4442(sgaE)
ECM: EcSMS35_0063(araD) EcSMS35_3906(sgbE) EcSMS35_4669(sgaE)
ECY: ECSE_0061(araD) ECSE_3859(sgbE) ECSE_4496(sgaE)
ECL: EcolC_0131(sgbE) EcolC_3596(araD) EcolC_3815(sgaE)
ECK: EC55989_0059(araD) EC55989_4040(sgbE) EC55989_4755(sgaE)
ECQ: ECED1_0060(araD) ECED1_4272(sgbE) ECED1_5048(sgaE)
ECR: ECIAI1_0061(araD) ECIAI1_3750(sgbE)
ECT: ECIAI39_0064(araD) ECIAI39_4095(sgbE) ECIAI39_4663(sgaE)
ECZ: ECS88_0064(araD) ECS88_4003(sgbE)
EUM: ECUMN_0062(araD) ECUMN_4096(sgbE) ECUMN_4731(sgaE)
ELF: LF82_0108(araD) LF82_2127(sgbE) LF82_2377(ulaF)
EBL: B21_00062(araD) B21_03386(sgbE)
EBD: ECBD_0151 ECBD_3556
EBR: ECB_00063(araD) ECB_03435(sgbE)
EOH: ECO103_0062(araD)
EOI: ECO111_0063(araD)
EOJ: ECO26_0063(araD)
EFE: EFER_0070(araD) EFER_3581(sgbE)
STY: STY0118(araD) STY4119(sgbE) STY4744(sgaE)
STT: t0105(araD) t3842(sgbE) t4439(sgaE)
SPT: SPA0103(araD) SPA3528(sgbE) SPA4205(sgaE)
SEK: SSPA0099(araD) SSPA3294(sgbE) SSPA3905(sgaE)
SPQ: SPAB_00128(araD) SPAB_04568(sgbE) SPAB_05522(sgaE)
SEI: SPC_0108(araD) SPC_3757(yiaS) SPC_4535(sgaE)
SEC: SC0095(araD) SC4262(sgaE)
SEH: SeHA_C0107(araD) SeHA_C4000(sgbE) SeHA_C4806(sgaE)
SEE: SNSL254_A0108(araD) SNSL254_A3955(sgbE) SNSL254_A4749(sgaE)
SEW: SeSA_A0112(araD) SeSA_A3875(sgbE) SeSA_A4656(sgaE)
SEA: SeAg_B0112(araD) SeAg_B3891(sgbE) SeAg_B4666(sgaE)
SED: SeD_A0105(araD) SeD_A4062(sgbE) SeD_A4785(sgaE)
SEG: SG0102(araD) SG3753(sgbE) SG4230(sgaE)
SET: SEN0102(araD) SEN3499(sgbE) SEN4154(sgaE)
SES: SARI_02904(araD) SARI_03245(sgaE)
STM: STM0101(araD) STM3677(sgbE) STM4388(sgaE)
YPE: YPO2230(araD) YPO3326(araD)
YPK: y0863(araD) y2072(araD)
YPM: YP_0360(araD) YP_2029(araD)
YPA: YPA_1590(araD) YPA_2818(araD)
YPN: YPN_0767(araD) YPN_1699(araD)
YPG: YpAngola_A0923(araD) YpAngola_A2239(araD)
YPP: YPDSF_0904(araD) YPDSF_3034(araD)
YPS: YPTB0804(araD) YPTB2152(araD)
YPI: YpsIP31758_1910(araD) YpsIP31758_3262(araD)
YPY: YPK_2021(araD) YPK_3395(araD)
YPB: YPTS_0839(araD) YPTS_2222(araD)
YEN: YE1976(araD)
SFL: SF0056(araD) SF4353(sgaE)
SFX: S0058(araD) S4623(sgaE)
SFV: SFV_0053(araD) SFV_3956(sgbE) SFV_4354(sgaE)
SSN: SSON_0067(araD) SSON_4380(sgaE)
SBO: SBO_0048(araD)
SBC: SbBS512_E0053(araD) SbBS512_E4728(sgaE)
SDY: SDY_0088(araD) SDY_4367(sgaE)
ECA: ECA1960(araD)
PCT: PC1_2362
PWA: Pecwa_2637
ETA: ETA_16270(araD)
SGL: SG1415(araD)
ENT: Ent638_0608(araD)
ESA: ESA_03278(araD)
CTU: Ctu_06930(araD)
KPN: KPN_00060(araD) KPN_04591(sgaE)
KPE: KPK_0159(sgbE) KPK_4682(araD) KPK_5076(sgaE)
KPU: KP1_0465(sgaE) KP1_0873(araD)
CKO: CKO_03321(araD) CKO_03636(sgaE) CKO_05041(sgbE)
SPE: Spro_2644(araD) Spro_3939(sgbE)
DDA: Dd703_1706
DDC: Dd586_1690
DZE: Dd1591_1739
HIN: HI1025(sgbE)
HDU: HD1866(araD)
HAP: HAPS_1782(sgbE)
HSO: HS_0773(sgbE)
HSM: HSM_1240(sgbE)
PMU: PM1244(sgbE)
MSU: MS0046(sgbE)
APL: APL_1704(araD)
APJ: APJL_1736(araD)
APA: APP7_1765(araD)
ASU: Asuc_0234(araD)
AAP: NT05HA_1243
AAT: D11S_1052
VCH: VCA0244(araD)
VCO: VC0395_0985(araD)
VCM: VCM66_A0240
VCJ: VCD_000010
VVU: VV2_1082(araD)
VVY: VVA1606(araD)
VSP: VS_II0142(araD)
PPR: PBPRB0275(araD)
SBP: Sbal223_2139(araD)
SPC: Sputcn32_2067(araD)
SHE: Shewmr4_1978(araD)
SHM: Shewmr7_1996(araD)
SHN: Shewana3_2065(araD)
SHW: Sputw3181_1945(araD)
SDE: Sde_0773(araD)
AHA: AHA_1901(araD)
ASA: ASA_2398(araD)
TAU: Tola_3068
BSU: BSU28780(araD)
BHA: BH1871(araD)
BLI: BL00350(sgaE) BL01183(araD)
BLD: BLi02063(araD) BLi03026(sgaE)
BCL: ABC0406(araD)
BAY: RBAM_025840(araD)
BPU: BPUM_2328(araD)
OIH: OB2798(araD)
GKA: GK1906(araD)
GTN: GTNG_1797(araD)
GYC: GYMC61_2736
AFL: Aflv_0529(araD)
PJD: Pjdr2_4207
AAC: Aaci_2898
LLK: LLKF_1617(araD)
SPY: SPy_0179(araD)
SPZ: M5005_Spy_0153(araD)
SPM: spyM18_0178(araD)
SPG: SpyM3_0140(araD)
SPS: SPs0143(araD)
SPH: MGAS10270_Spy0155(araD)
SPI: MGAS10750_Spy0159(araD)
SPJ: MGAS2096_Spy0161(araD)
SPK: MGAS9429_Spy0155(araD)
SPF: SpyM50147(araD)
SPA: M6_Spy0199(araD)
SPB: M28_Spy0151(araD)
SOZ: Spy49_0158(araD)
SPN: SP_2033(araD)
SPD: SPD_1842(araD)
SPR: spr1844(araD)
SPW: SPCG_1998(araD)
SPX: SPG_1946
SNE: SPN23F_20540
SPV: SPH_2186(araD)
SNM: SP70585_2119
SJJ: SPJ_2039
SPP: SPP_2069
SNT: SPT_2028
SAG: SAG1810(araD)
SAN: gbs1851(araD)
SAK: SAK_1830(araD)
SMU: SMU.275(araD)
SSA: SSA_2088(araD)
SSU: SSU05_2058(araD)
SSV: SSU98_2061(araD)
SSB: SSUBM407_1913
SSI: SSU1843
SSS: SSUSC84_1865
SEQ: SZO_01510
SEZ: Sez_0173(araD)
SEU: SEQ_0246
SUB: SUB1722
SDS: SDEG_2008(araD)
LPL: lp_3555(araD)
LPJ: JDM1_2840(araD)
LSA: LSA1857(araD)
LBR: LVIS_1741(araD)
LCA: LSEI_2731(araD)
LCB: LCABL_29070(araD)
LRE: Lreu_0481(araD)
LRF: LAR_0469(araD)
LFE: LAF_1557(araD)
LRH: LGG_02723(araD)
LRL: LC705_02728(araD)
EFA: EF1131(araD)
LME: LEUM_0855(araD) LEUM_1992(araD)
LCI: LCK_01182(araD)
CAC: CAC1341(araD)
CPF: CPF_0648(araD)
CDF: CD2278(araD)
CDC: CD196_2133(araD)
CDL: CDR20291_2176(araD)
CBK: CLL_A3262(araD)
CBT: CLH_3015(araD)
CPY: Cphy_3928(araD)
CCE: Ccel_3467
ATE: Athe_2227
ERE: EUBREC_0669
CSC: Csac_0723
MPN: MPN498(araD)
MPU: MYPU_5990(araD)
MPE: MYPE7160(araD)
MHY: mhp439(araD)
MHJ: MHJ_0434(araD)
MHP: MHP7448_0436(araD)
MSY: MS53_0031(araD)
MAA: MAG_6330(araD)
MSM: MSMEG_1714
TWH: TWT647(araD)
TWS: TW669(sgaE)
CMI: CMM_0877(araD)
CMS: CMS_0132
ART: Arth_0223
AAU: AAur_3710(araD)
ACH: Achl_0380
BCV: Bcav_3273
BFA: Bfae_29510
JDE: Jden_0497
XCE: Xcel_0402
PAC: PPA0882 PPA2325
NCA: Noca_0381
SRO: Sros_6218
ACE: Acel_0872
AMI: Amir_1862
CAI: Caci_4714
BLO: BL0273(araD)
BLJ: BLD_1019(araD)
BAD: BAD_1411(araD)
BLA: BLA_0057(araD)
BLC: Balac_0067
BLT: Balat_0067
APV: Apar_0330
ACA: ACP_2791
SUS: Acid_1230(araD)
BTH: BT_0353(araD)
RMR: Rmar_0470
DFE: Dfer_2396
CPI: Cpin_3995
PHE: Phep_2730
GFO: GFO_0698(araD)
FJO: Fjoh_1120(araD)
RBI: RB2501_09545
STR: Sterm_0035 Sterm_0125 Sterm_0147
SMF: Smon_1319
OTE: Oter_1381
HAU: Haur_3663
TMA: TM0283
TPT: Tpet_0629
TLE: Tlet_1139
TRQ: TRQ2_0654
TNA: CTN_0401
TNP: Tnap_0915
DTH: DICTH_1621
DTU: Dtur_1734
HUT: Huta_1149
 |
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| Structures |
PDB: 1JDI 1K0W |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:13539036]
BURMA DP, HORECKER BL.
Not Available
J. Biol. Chem. 231 (1958) 1053-64.
Lactobucillus plantarum |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4395381]
Deupree JD.
Wood WA: L-ribulose 5-phosphate 4-epimerase of Aerobacter aerogenes.
Evidence for nicotinamide adenine dinucleotide-independent
4-epimerization by the crystalline enzyme.
J. Biol. Chem. 245 (1970) 3988-95.
Klebsiella pneumoniae [GN:kpn] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:4879898]
Lee N, Patrick JW, Masson M.
Crystalline L-ribulose 5-phosphate 4-epimerase from Escherichia
coli.
J. Biol. Chem. 243 (1968) 4700-5.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13549442]
WOLIN MJ, SIMPSON FJ, WOOD WA.
Degradation of L-arabinose by Aerobacter aerogenes. III.
Identification and properties of L-ribulose-5-phosphate 4-epimerase.
J. Biol. Chem. 232 (1958) 559-75.
Klebsiella pneumoniae [GN:kpn] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:8520491]
Andersson A, Schneider G, Lindqvist Y.
Purification and preliminary X-ray crystallographic studies of
recombinant L-ribulose-5-phosphate 4-epimerase from Escherichia
coli.
Protein. Sci. 4 (1995) 1648-50.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:10769139]
Lee LV, Poyner RR, Vu MV, Cleland WW.
Role of metal ions in the reaction catalyzed by
L-ribulose-5-phosphate 4-epimerase.
Biochemistry. 39 (2000) 4821-30.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:11732896]
Samuel J, Luo Y, Morgan PM, Strynadka NC, Tanner ME.
Catalysis and binding in L-ribulose-5-phosphate 4-epimerase: a
comparison with L-fuculose-1-phosphate aldolase.
Biochemistry. 40 (2001) 14772-80.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.1.3.4
IUBMB Enzyme Nomenclature: 5.1.3.4
ExPASy - ENZYME nomenclature database: 5.1.3.4
BRENDA, the Enzyme Database: 5.1.3.4
CAS: 9024-19-5 |
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