KEGG   ENZYME: 5.2.1.2Help
Entry
EC 5.2.1.2                  Enzyme                                 
Name maleylacetoacetate isomerase;
maleylacetoacetic isomerase;
maleylacetone isomerase;
maleylacetone cis-trans-isomerase
Class Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
BRITE hierarchy
Sysname 4-maleylacetoacetate cis-trans-isomerase
Reaction(IUBMB) 4-maleylacetoacetate = 4-fumarylacetoacetate [RN:R03181]
Reaction(KEGG) R03181;
(other) R03868
Show
Substrate 4-maleylacetoacetate [CPD:C01036]
Product 4-fumarylacetoacetate [CPD:C01061]
Comment Also acts on maleylpyruvate.
Pathway PATH: ec00350  Tyrosine metabolism
PATH: ec00643  Styrene degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K01800  maleylacetoacetate isomerase
Genes HSA: 2954(GSTZ1)
MMU: 14874(Gstz1)
RNO: 681913(Gstz1)
ECB: 100052190
MDO: 100017470
OAA: 100077359
GGA: 423374(GSTZ1)
TGU: 100229661
XLA: 496168
DRE: 436754
CIN: 100181506
SPU: 580863
DME: Dmel_CG9362 Dmel_CG9363
DPO: Dpse_GA21732
DAN: Dana_GF17762
DER: Dere_GG17371 Dere_GG17372
DPE: Dper_GL13668
DSE: Dsec_GM26256 Dsec_GM26257
DSI: Dsim_GD20795 Dsim_GD20796
DYA: Dyak_GE24775 Dyak_GE24777
DGR: Dgri_GH19138
DMO: Dmoj_GI23596
AGA: AgaP_AGAP002898(GSTZ1)
AAG: AaeL_AAEL011934
AME: 411088
TCA: 662347
ISC: IscW_ISCW023198
CEL: D1053.1(gst-42)
CBR: CBG00257
NVE: NEMVE_v1g186779
TAD: TRIADDRAFT_32265
POP: POPTR_742621
RCU: RCOM_1299540
VVI: 100252270
SBI: SORBI_04g023210(SORBIDRAFT_04g023210)
     SORBI_05g007005(SORBIDRAFT_05g007005)
ZMA: 542543(gst17)
PPP: PHYPADRAFT_199161
FGR: FG02852.1
AFM: AFUA_2G04240
AFV: AFLA_036070
PCS: Pc12g09020
NFI: NFIA_081030
CIM: CIMG_01314
URE: UREG_01240
MBR: MONBRDRAFT_21180
DDI: DDB_0231608(mai)
PTM: GSPATT00012005001 GSPATT00029106001
PTI: PHATRDRAFT_6848
TPS: THAPSDRAFT_33717
XCC: XCC0592(uptB)
XCB: XC_3641
XCA: xccb100_3758
XCV: XCV3731
XAC: XAC3608(uptB)
XOO: XOO0772(uptB)
XOM: XOO_0702
XOP: PXO_03149(maiA)
SML: Smlt0609
SMT: Smal_0482
VCH: VC1347
VCO: VC0395_A0964(maiA)
VCM: VCM66_1302(maiA)
VCJ: VCD_002992
VVU: VV1_2765
VVY: VV1498
VPA: VP1352
VHA: VIBHAR_02180
VSP: VS_II1518
VEX: VEA_003652
PPR: PBPRB1167
PAE: PA2007(maiA)
PAU: PA14_38550(maiA)
PAP: PSPA7_2765(maiA2) PSPA7_3282(maiA1)
PAG: PLES_33161(maiA)
PPU: PP_4619
PPF: Pput_4479
PPG: PputGB1_4603
PPW: PputW619_0819
PST: PSPTO_3554(maiA)
PSP: PSPPH_3251(maiA)
PFL: PFL_0969(maiA)
PFO: Pfl01_0912
PFS: PFLU1027
PEN: PSEEN2595(mhbI) PSEEN4610(maiA)
PMY: Pmen_1699
PSA: PST_0872
AVN: Avin_50200(maiA)
PCR: Pcryo_1561
PRW: PsycPRwf_0734
ACB: A1S_3415
ABM: ABSDF3594(hmgC)
ABY: ABAYE0067(hmgC)
ABC: ACICU_03611
ABN: AB57_3868(maiA)
ABB: ABBFA_000068(maiA)
SON: SO_1671
SDN: Sden_2591
SFR: Sfri_1332
SAZ: Sama_2218
SBL: Sbal_1488
SBM: Shew185_1483
SBN: Sbal195_1519
SBP: Sbal223_2864
SLO: Shew_1439
SPC: Sputcn32_1390
SSE: Ssed_2926
SPL: Spea_1452
SHE: Shewmr4_2603
SHM: Shewmr7_2670
SHN: Shewana3_2777
SHW: Sputw3181_2711
SHL: Shal_1535
SWD: Swoo_1719
SWP: swp_1654
ILO: IL0719
CPS: CPS_3762(maiA)
PHA: PSHAb0337(maiA)
PAT: Patl_1448
AMC: MADE_02826
LPN: lpg2280
LPF: lpl2206
LPP: lpp2234
LPC: LPC_1749
NOC: Noc_1440
HCH: HCH_00952(maiA)
MMW: Mmwyl1_2674 Mmwyl1_2736
AHA: AHA_2660(maiA)
ASA: ASA_2516(maiA)
KKO: Kkor_1516
CVI: CV_0972
RSO: RSc0384
RPI: Rpic_0240
RPF: Rpic12D_0261
REU: Reut_A0333 Reut_B5804 Reut_B5862
REH: H16_A0362
RME: Rmet_0280
CTI: RALTA_A0307
BMA: BMA3128(maiA)
BMV: BMASAVP1_A0097(maiA)
BML: BMA10229_A1492(maiA)
BMN: BMA10247_2921(maiA)
BPS: BPSL0513
BPM: BURPS1710b_0744(maiA)
BPL: BURPS1106A_0575(maiA)
BPD: BURPS668_0560(maiA)
BPR: GBP346_A0487(maiA)
BTE: BTH_I0465(maiA)
BVI: Bcep1808_2915
BUR: Bcep18194_A6140 Bcep18194_B1887
BCN: Bcen_2196 Bcen_4219
BCH: Bcen2424_2810 Bcen2424_4147
BCM: Bcenmc03_2821 Bcenmc03_3372
BCJ: BCAL0792 BCAM1273(mhbI)
BAM: Bamb_2870
BAC: BamMC406_2728
BMU: Bmul_0491 Bmul_4440
BMJ: BMULJ_02764(maiA) BMULJ_04069(maiA)
BXE: Bxe_A2723 Bxe_A4141
BPH: Bphy_0307
BPY: Bphyt_0577
BGL: bglu_2g18600
PNU: Pnuc_1851
BPE: BP1238
BPA: BPP1853
BBR: BB3255
BPT: Bpet0513 Bpet3146
BAV: BAV1784(nagL) BAV2402(maaI)
POL: Bpro_0991 Bpro_2136
PNA: Pnap_2807
AAV: Aave_0148 Aave_2474
AJS: Ajs_2077
DAC: Daci_3597 Daci_3700
DIA: Dtpsy_1678
VAP: Vapar_2019
CTT: CtCNB1_2354 CtCNB1_2780
MPT: Mpe_A1872
LCH: Lcho_2090 Lcho_3672
EBA: ebA1379(nagL)
TMZ: Tmz1t_0854
APP: CAP2UW1_2310
BBA: Bd0291(maiA)
ADE: Adeh_3421
ACP: A2cp1_3570
AFW: Anae109_3483
ANK: AnaeK_3502
MXA: MXAN_6348(maiA)
SCL: sce5978
HOH: Hoch_6554
MLO: mlr1135
MES: Meso_0055 Meso_3563
PLA: Plav_3583
SME: SMc03206(maiA)
SMD: Smed_2831
ARA: Arad_7201(maiA) Arad_8214(maiA)
RET: RHE_CH01748(maiA)
REC: RHECIAT_CH0001829(maiA) RHECIAT_CH0002509
RLE: RL1866 RL2736(maiA)
RLT: Rleg2_1409 Rleg2_2048
RLG: Rleg_1513 Rleg_2272
RHI: NGR_c29950
BJA: bll0109
BRA: BRADO0684(maiA) BRADO5975
BBT: BBta_1799 BBta_6278 BBta_6524 BBta_7500(maiA)
RPA: RPA4671(maiA)
RPB: RPB_0908
RPD: RPD_1019
RPT: Rpal_5152
NHA: Nham_0920
XAU: Xaut_3331
MEX: Mext_2639
MEA: Mex_1p2830(maiA)
MDI: METDI3396(maiA)
MRD: Mrad2831_3679
MPO: Mpop_1046 Mpop_2762
MCH: Mchl_2865
MNO: Mnod_1191
BID: Bind_0562
CCS: CCNA_03683
CAK: Caul_0071
PZU: PHZ_c0314
SIL: SPO0679(hmgC)
SIT: TM1040_2626
JAN: Jann_1437
RDE: RD1_3652(maiA)
PDE: Pden_0174 Pden_3549
MMR: Mmar10_1997
HNE: HNE_1992(maiA)
HBA: Hbal_2638
NAR: Saro_3441
SWI: Swit_3058 Swit_3352 Swit_5085
RCE: RC1_2508(maiA)
SYD: Syncc9605_0553
Taxonomy
Structures PDB: 1FW1  2CZ2  2CZ3  2JL4  2V6K  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13319328]
EDWARDS SW, KNOX WE.
Homogentisate metabolism:  the isomerization of maleylacetoacetate
by an enzyme which requires glutathione.
J. Biol. Chem. 220 (1956) 79-91.
Bos taurus [GN:bta], Rattus norvegicus [GN:rno]
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:14461395]
LACK L.
Enzymic cis-trans isomerization of maleylpyruvic acid.
J. Biol. Chem. 236 (1961) 2835-40.
Pseudomonas sp.
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:4692831]
Seltzer S.
Purification and properties of maleylacetone cis-trans isomerase
from vibrio 01.
J. Biol. Chem. 248 (1973) 215-22.
Vibrio sp.
Other DBs ExplorEnz - The Enzyme Database: 5.2.1.2
IUBMB Enzyme Nomenclature: 5.2.1.2
ExPASy - ENZYME nomenclature database: 5.2.1.2
UM-BBD (Biocatalysis/Biodegradation Database): 5.2.1.2
BRENDA, the Enzyme Database: 5.2.1.2
CAS: 9023-75-0
DBGET integrated database retrieval system