KEGG   ENZYME: 5.3.2.1Help
Entry
EC 5.3.2.1                  Enzyme                                 

Name
phenylpyruvate tautomerase;
phenylpyruvic keto-enol isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting keto- and enol-groups
BRITE hierarchy
Sysname
phenylpyruvate keto---enol-isomerase
Reaction(IUBMB)
keto-phenylpyruvate = enol-phenylpyruvate [RN:R01378]
Reaction(KEGG)
R01378;
(other) R03342
Show
Substrate
keto-phenylpyruvate [CPD:C00166]
Product
enol-phenylpyruvate [CPD:C02763]
Comment
Also acts on other arylpyruvates.
History
EC 5.3.2.1 created 1961
Pathway
Tyrosine metabolism
Phenylalanine metabolism
Orthology
K07253  
phenylpyruvate tautomerase
Genes
HSA: 
4282(MIF)
PTR: 
748716(MIF)
PPS: 
GGO: 
PON: 
MCC: 
574298(MIF)
MCF: 
MMU: 
17319(Mif)
RNO: 
81683(Mif)
CGE: 
HGL: 
TUP: 
CFA: 
AML: 
FCA: 
BTA: 
280858(MIF)
OAS: 
780466(MIF)
SSC: 
397412(MIF)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
OAA: 
GGA: 
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
XLA: 
399041(mif)
XTR: 
DRE: 
751093(mif)
TRU: 
503499(mif)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
TCA: 
BMOR: 
API: 
CEL: 
CBR: 
CBG13302(Cbr-mif-1)
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
TAD: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
PPER: 
MDM: 
CSV: 
RCU: 
POP: 
POPTR_0006s10550g(POPTRDRAFT_653171) POPTR_0006s10570g(POPTRDRAFT_831933) POPTR_0016s13420g(POPTRDRAFT_668121) POPTR_0064s00280g
SLY: 
SOT: 
BDI: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
BPG: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
PBL: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT111593(AGABI1DRAFT_111593) AGABI1DRAFT69253(AGABI1DRAFT_69253)
ABV: 
AGABI2DRAFT200279(AGABI2DRAFT_200279) AGABI2DRAFT217233(AGABI2DRAFT_217233)
CPUT: 
SLA: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:5824560]
  Authors
Blasi F, Fragomele F, Covelli I.
  Title
Thyroidal phenylpyruvate tautomerase. Isolation and characterization.
  Journal
J. Biol. Chem. 244 (1969) 4864-70.
Reference
2
  Authors
Knox, W.E.
  Title
p-Hydroxyphenylpyruvate enol-keto tautomerase.
  Journal
Methods Enzymol. 2 (1955) 289-295.
Reference
3  [PMID:13416270]
  Authors
KNOX WE, PITT BM.
  Title
Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids.
  Journal
J. Biol. Chem. 225 (1957) 675-88.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9023-54-5

KEGG   ENZYME: 5.3.3.12Help
Entry
EC 5.3.3.12                 Enzyme                                 

Name
L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
L-dopachrome keto-enol isomerase
Reaction(IUBMB)
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN:R03673]
Reaction(KEGG)
Substrate
L-dopachrome [CPD:C01693]
Product
5,6-dihydroxyindole-2-carboxylate [CPD:C04185]
Comment
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
History
EC 5.3.3.12 created 1992, modified 1999, modified 2005
Pathway
Tyrosine metabolism
Metabolic pathways
Orthology
K01827  
dopachrome tautomerase
Genes
HSA: 
1638(DCT)
PTR: 
452622(DCT)
PPS: 
GGO: 
PON: 
MCC: 
694577(DCT)
MCF: 
MMU: 
13190(Dct)
RNO: 
290484(Dct)
CGE: 
HGL: 
TUP: 
CFA: 
485520(DCT)
AML: 
FCA: 
PTG: 
BTA: 
280761(DCT)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
574066(DCT)
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
395775(DCT)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XTR: 
549915(dct)
DRE: 
58074(dct)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
TSP: 
 » show all
Taxonomy
Reference
1  [PMID:8573077]
  Authors
Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA.
  Title
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.
  Journal
Biochem. J. 313 ( Pt 2) (1996) 447-53.
  Sequence
[mmu:13190]
Reference
2  [PMID:2106316]
  Authors
Pawelek JM.
  Title
Dopachrome conversion factor functions as an isomerase.
  Journal
Biochem. Biophys. Res. Commun. 166 (1990) 1328-33.
Reference
3  [PMID:9794786]
  Authors
Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ.
  Title
Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.
  Journal
Biochem. J. 335 ( Pt 3) (1998) 495-8.
  Sequence
[up:P81529]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
130122-81-5

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