KEGG   ENZYME: 5.3.3.1Help
Entry
EC 5.3.3.1                  Enzyme                                 
Name steroid Delta-isomerase;
hydroxysteroid isomerase;
steroid isomerase;
Delta5-ketosteroid isomerase;
Delta5(or Delta4)-3-keto steroid isomerase;
Delta5-steroid isomerase;
3-oxosteroid isomerase;
Delta5-3-keto steroid isomerase;
Delta5-3-oxosteroid isomerase
Class Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname 3-oxosteroid Delta5-Delta4-isomerase
Reaction(IUBMB) a 3-oxo-Delta5-steroid = a 3-oxo-Delta4-steroid [RN:R02644]
Reaction(KEGG) R02644;
(other) R01837 R02216 R02499 R02840 R03327 R04163 R04678 R04849
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Substrate 3-oxo-Delta5-steroid [CPD:C01034]
Product 3-oxo-Delta4-steroid [CPD:C00619]
Comment May be at least three distinct enzymes.
Pathway PATH: ec00140  Steroid hormone biosynthesis
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01070  Biosynthesis of plant hormones
PATH: ec01100  Metabolic pathways
Orthology KO: K00070  3beta-hydroxy-delta5-steroid dehydrogenase / steroid
            delta-isomerase
KO: K01822  steroid delta-isomerase
Genes HSA: 3283(HSD3B1) 3284(HSD3B2)
PTR: 457165(HSD3B2) 469446(HSD3B1)
MCC: 712686(HSD3B2) 713091(HSD3B1)
MMU: 15492(Hsd3b1) 15493(Hsd3b2) 15495(Hsd3b4) 15496(Hsd3b5)
     15497(Hsd3b6)
RNO: 24470(Hsd3b5) 29632(Hsd3b6) 360348(Hsd3b1)
CFA: 483146(HSD3B1)
BTA: 281824(HSD3B1)
SSC: 445539(HSD3B1)
ECB: 100034078(HSD3B1)
MDO: 100012668
OAA: 100080135
GGA: 396015(HSD3B1)
TGU: 751770(HSD3B1)
XLA: 734818
DRE: 373131(hsd3b1) 553532
BFO: BRAFLDRAFT_221648
CIN: 100175469 100177791
SPU: 592634
DME: Dmel_CG7724
DPO: Dpse_GA20545
DAN: Dana_GF10105
AGA: AgaP_AGAP006654
AAG: AaeL_AAEL000733
CQU: CpipJ_CPIJ003056
NVI: 100120136
SPL: Spea_2174
SHL: Shal_2145
REU: Reut_A1514
REH: H16_B0602
CTI: RALTA_B0406
AJS: Ajs_2963
DIA: Dtpsy_2390
AZO: azo3316
TMZ: Tmz1t_1060
MLO: mlr2180
XAU: Xaut_1492
HNE: HNE_1461
NAR: Saro_3596 Saro_3765
SWI: Swit_3295
OIH: OB0288
MTU: Rv0760c
MTC: MT0785
MRA: MRA_0770
MTF: TBFG_10775
MBO: Mb0783c
MBB: BCG_0812c
MBT: JTY_0782
MPA: MAP2478 MAP2705c
MAV: MAV_1209 MAV_1444
MSM: MSMEG_5258
MUL: MUL_0195 MUL_0468
MVA: Mvan_4664
MGI: Mflv_2053
MAB: MAB_1206
MMC: Mmcs_4139
MKM: Mkms_4214
MJL: Mjls_4370
MMI: MMAR_4382 MMAR_4937
NFA: nfa13370 nfa22430
RHA: RHA1_ro03609 RHA1_ro09001
RER: RER_13740(ksi) RER_59940
ROP: ROP_34080
SGR: SGR_6072
NCA: Noca_3954
FAL: FRAAL4373
SEN: SACE_4441
SAQ: Sare_2441
GAU: GAU_3360
CYT: cce_2283
CYC: PCC7424_2031
CYN: Cyan7425_3259
GVI: gll2890
ANA: alr1545
AVA: Ava_4985
CTS: Ctha_1369
Taxonomy
Structures PDB: 1BUQ  1C7H  1CQS  1DMM  1DMN  1DMQ  1E97  1GS3  1ISK  1K41  
     1OCV  1OGX  1OGZ  1OH0  1OHO  1OHP  1OHS  1OPY  1VZZ  1W00  
     1W01  1W02  1W6Y  2INX  2PZV  3CPO  3FZW  3IPT  8CHO  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5867327]
Ewald W, Werbin H, Chaikoff IL.
Evidence for the presence of 17-hydroxypregnenedione isomerase in
beef adrenal cortex.
Biochim. Biophys. Acta. 111 (1965) 306-12.
Bos taurus [GN:bta]
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:14404954]
KAWAHARA FS, TALALAY P.
Crystalline Delta 5-3-ketosteroid isomerase.
J. Biol. Chem. 235 (1960) PC1-2.
Pseudomonas testosteroni
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:13276386]
TALALAY P, WANG VS.
Enzymic isomerization of delta5-3-ketosteroids.
Biochim. Biophys. Acta. 18 (1955) 300-1.
Pseudomonas sp.
Other DBs ExplorEnz - The Enzyme Database: 5.3.3.1
IUBMB Enzyme Nomenclature: 5.3.3.1
ExPASy - ENZYME nomenclature database: 5.3.3.1
BRENDA, the Enzyme Database: 5.3.3.1
CAS: 9031-36-1
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