KEGG   ENZYME: 5.3.3.12Help
Entry
EC 5.3.3.12                 Enzyme                                 

Name
L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
L-dopachrome keto-enol isomerase
Reaction(IUBMB)
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN:R03673]
Reaction(KEGG)
Substrate
L-dopachrome [CPD:C01693]
Product
5,6-dihydroxyindole-2-carboxylate [CPD:C04185]
Comment
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
Pathway
Tyrosine metabolism
Metabolic pathways
Orthology
K01827  
dopachrome tautomerase
Genes
HSA: 
1638(DCT)
PTR: 
452622(DCT)
PPS: 
GGO: 
PON: 
MCC: 
694577(DCT)
MCF: 
MMU: 
13190(Dct)
RNO: 
290484(Dct)
CGE: 
HGL: 
TUP: 
CFA: 
485520(DCT)
AML: 
FCA: 
BTA: 
280761(DCT)
BOM: 
PHD: 
CHX: 
SSC: 
574066(DCT)
CFR: 
ECB: 
MYB: 
MDO: 
SHR: 
OAA: 
GGA: 
395775(DCT)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
ACS: 
XTR: 
549915(dct)
DRE: 
58074(dct)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
TSP: 
 » show all
Taxonomy
Reference
1  [PMID:8573077]
  Authors
Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA.
  Title
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.
  Journal
Biochem. J. 313 ( Pt 2) (1996) 447-53.
  Organism
Mus musculus [GN:mmu]
  Sequence
[mmu:13190]
Reference
2  [PMID:2106316]
  Authors
Pawelek JM.
  Title
Dopachrome conversion factor functions as an isomerase.
  Journal
Biochem. Biophys. Res. Commun. 166 (1990) 1328-33.
  Organism
Mus musculus [GN:mmu]
Reference
3  [PMID:9794786]
  Authors
Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ.
  Title
Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.
  Journal
Biochem. J. 335 ( Pt 3) (1998) 495-8.
  Organism
Trichinella spiralis, Trichuris muris, Brugia pahangi
  Sequence
[up:P81529]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
130122-81-5

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