KEGG   ENZYME: 5.3.99.2Help
Entry
EC 5.3.99.2                 Enzyme                                 

Name
prostaglandin-D synthase;
prostaglandin-H2 Delta-isomerase;
prostaglandin-R-prostaglandin D isomerase;
PGH-PGD isomerase(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase (incorrect);
(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase;
prostaglandin endoperoxide Delta-isomerase;
prostaglandin D synthetase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Reaction(IUBMB)
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [RN:R02266]
Reaction(KEGG)
Substrate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696]
Comment
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
History
EC 5.3.99.2 created 1976, modified 1990
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K01830  
prostaglandin-H2 D-isomerase
K04097  
prostaglandin-H2 D-isomerase / glutathione transferase
Genes
HSA: 
27306(HPGDS) 5730(PTGDS)
PTR: 
100610452(PTGDS) 743219(HPGDS)
PPS: 
100983768(PTGDS) 100990241(HPGDS)
GGO: 
101123835(HPGDS)
PON: 
100442014(HPGDS) 100459419(PTGDS)
NLE: 
100592404(PTGDS) 100598180(HPGDS)
MCC: 
705227(HPGDS) 707990(PTGDS)
MCF: 
101926100(PTGDS) 102131661(HPGDS)
CSAB: 
RRO: 
104669645(PTGDS) 104679857(HPGDS)
CJC: 
SBQ: 
101033870(PTGDS) 101048967(HPGDS)
MMU: 
19215(Ptgds) 54486(Hpgds)
RNO: 
25526(Ptgds) 58962(Hpgds)
CGE: 
100762704(Ptgds) 100768035(Hpgds)
NGI: 
103741183(Ptgds) 103743362(Hpgds)
HGL: 
101699559(Ptgds) 101706734(Hpgds)
OCU: 
TUP: 
102482208(PTGDS) 102485301(HPGDS)
CFA: 
403740(PTGDS) 478481(HPGDS)
AML: 
100466392(HPGDS) 100474593(PTGDS)
UMR: 
103675299(PTGDS) 103677906(HPGDS)
FCA: 
101083337(HPGDS) 493852(PTGDS)
PTG: 
102962017(PTGDS) 102970849(HPGDS)
BTA: 
100139892(HPGDS) 286858(PTGDS)
BOM: 
102269024(HPGDS) 102274981(PTGDS)
PHD: 
CHX: 
102191223(HPGDS) 106502686(PTGDS)
OAS: 
101116145(HPGDS) 443192(PTGDS)
SSC: 
100623584(HPGDS) 397456(PTGDS)
CFR: 
102512148(PTGDS) 102513633(HPGDS)
BACU: 
103013138(PTGDS) 103019771(HPGDS)
LVE: 
103079273(HPGDS) 103088196(PTGDS)
ECB: 
100053460(HPGDS) 100067921(PTGDS)
MYB: 
102238842(PTGDS) 102240667(HPGDS)
MYD: 
102767586(HPGDS) 102773498(PTGDS)
PALE: 
102889838(PTGDS) 102895654(HPGDS)
LAV: 
100666840(HPGDS) 100672974(PTGDS)
MDO: 
100016454(HPGDS) 100022407(PTGDS)
SHR: 
100913465(PTGDS) 100926080(HPGDS)
OAA: 
GGA: 
374110(PTGDS) 395863(HPGDS)
MGP: 
CJO: 
APLA: 
TGU: 
GFR: 
FAB: 
PHI: 
102102732(HPGDS) 102105998(PTGDS)
CCW: 
104688201(PTGDS) 104697200(HPGDS)
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
102565053(PTGDS) 102574977(HPGDS)
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XLA: 
379417(hpgds-b) 397884(ptgds-b) 398969(hpgds-a) 444723(ptgds-a)
XTR: 
448666(hpgds) 779694(c8g.2)
DRE: 
336492(ptgdsb.1) 751701(ptgdsb.2)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
103184489(hpgds)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD25495(Dsim_GD25495)
DWI: 
DYA: 
Dyak_GE14214(dyak_GLEANR_14354)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AgaP_AGAP010404(GST_ANOGA)
AAG: 
CQU: 
AME: 
411045(GstS4) 552283 552304(GstS1)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
100115049(GstS3) 100115470(GstS8) 100115878(GstS7) 100116992(GstS5) 100117248(GstS1) 100120287(GstS4) 100121487(GstS6) 100124012(GstS2)
TCA: 
BMOR: 
692543(GSTs2) 692631(GSTs1)
DPL: 
PXY: 
API: 
PHU: 
DPX: 
CEL: 
CELE_R05F9.5(gst-9) CELE_R11G1.3(gst-11) CELE_ZK546.11(gst-30)
CBR: 
CBG02268(Cbr-gst-9) CBG02278(Cbr-gst-30) CBG14247(Cbr-gst-11)
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
Smp_054160(GST28)
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
OLU: 
BPG: 
MIS: 
MPP: 
CCP: 
FPU: 
NHE: 
TRE: 
AFV: 
SHS: 
ADL: 
SLA: 
PGR: 
SRE: 
DDI: 
DPP: 
DFA: 
SMIN: 
v1.2.003070.t1(symbB.v1.2.003070.t1) v1.2.014814.t1(symbB.v1.2.014814.t1) v1.2.014815.t1(symbB.v1.2.014815.t1) v1.2.017551.t1(symbB.v1.2.017551.t1) v1.2.017577.t1(symbB.v1.2.017577.t1) v1.2.027234.t1(symbB.v1.2.027234.t1) v1.2.040628.t2(symbB.v1.2.040628.t2)
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
NGR: 
VFL: 
GSN: 
TSN: 
PKT: 
AZI: 
MCG: 
MIC: 
 » show all
Taxonomy
Reference
1  [PMID:32914]
  Authors
Christ-Hazelhof E, Nugteren DH.
  Title
Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme.
  Journal
Biochim. Biophys. Acta. 572 (1979) 43-51.
Reference
2  [PMID:109431]
  Authors
Shimizu T, Yamamoto S, Hayaishi O.
  Title
Purification and properties of prostaglandin D synthetase from rat brain.
  Journal
J. Biol. Chem. 254 (1979) 5222-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65802-85-9

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