KEGG   ENZYME: 5.3.99.2Help
Entry
EC 5.3.99.2                 Enzyme                                 
Name
prostaglandin-D synthase;
prostaglandin-H2 Delta-isomerase;
prostaglandin-R-prostaglandin D isomerase;
PGH-PGD isomerase(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase (incorrect);
(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase;
prostaglandin endoperoxide Delta-isomerase;
prostaglandin D synthetase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Reaction(IUBMB)
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [RN:R02266]
Reaction(KEGG)
Substrate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696]
Comment
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K01830  
prostaglandin-H2 D-isomerase
Genes
HSA: 
27306(HPGDS) 5730(PTGDS)
PTR: 
743219(HPGDS) 749402(PTGDS)
PPS: 
100983768(PTGDS) 100990241(HPGDS)
GGO: 
101123835(HPGDS) 101130674(PTGDS)
PON: 
100442014(HPGDS) 100459419(PTGDS)
MCC: 
705227(HPGDS) 707990(PTGDS)
MMU: 
19215(Ptgds) 54486(Hpgds)
RNO: 
25526(Ptgds) 58962(Hpgds)
CFA: 
403740(PTGDS) 478481(HPGDS)
AML: 
FCA: 
101083337(HPGDS) 493852(PTGDS)
BTA: 
100139892(HPGDS) 286858(PTGDS)
SSC: 
100623584 397456(PTGDS)
ECB: 
100053460 100067921(PTGDS)
MDO: 
100016454 100022407
SHR: 
100913465(PTGDS) 100926080
OAA: 
100078645 100085740
GGA: 
374110(PTGDS) 395863(HPGDS)
MGP: 
100541600 100545080
TGU: 
100218607 100224496(HPGDS)
XLA: 
379417(hpgds-b) 397884(ptgds-b) 398969(hpgds-a) 444723(ptgds-a)
XTR: 
448666(hpgds) 779694(c8g.2)
DRE: 
336492(ptgdsb) 751701(id:ibd5130)
TRU: 
101062110 101063432
OLA: 
101165663 101166755
BFO: 
BRAFLDRAFT_202195 BRAFLDRAFT_209284 BRAFLDRAFT_209383 BRAFLDRAFT_212635 BRAFLDRAFT_212636 BRAFLDRAFT_277735
CIN: 
100177239 751081
NVI: 
100120287(GstS4)
TCA: 
659229 659302
API: 
100160859
PHU: 
Phum_PHUM284550
CBR: 
CBG02268(Cbr-gst-9) CBG02278(Cbr-gst-30)
SMM: 
Smp_054160(GST28)
TAD: 
TRIADDRAFT_30435 TRIADDRAFT_60170 TRIADDRAFT_63905
AQU: 
100638134
VCN: 
VOLCADRAFT_109826
OLU: 
OSTLU_7734
PGR: 
PGTG_11129
NGR: 
NAEGRDRAFT_82475(FM173)
DPP: 
DICPUDRAFT_58145 DICPUDRAFT_73373
 » show all
Taxonomy
Reference
1  [PMID:32914]
  Authors
Christ-Hazelhof E, Nugteren DH.
  Title
Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzyme.
  Journal
Biochim. Biophys. Acta. 572 (1979) 43-51.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:109431]
  Authors
Shimizu T, Yamamoto S, Hayaishi O.
  Title
Purification and properties of prostaglandin D synthetase from rat brain.
  Journal
J. Biol. Chem. 254 (1979) 5222-8.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65802-85-9
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