KEGG   ENZYME: 5.3.99.4Help
Entry
EC 5.3.99.4                 Enzyme                                 

Name
prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [RN:R02267]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [CPD:C01312]
Comment
Converts prostaglandin H2 into prostaglandin I2 (prostacyclin). A heme-thiolate protein.
History
EC 5.3.99.4 created 1984, modified 1990
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K01831  
prostacyclin synthase
Genes
HSA: 
5740(PTGIS)
PTR: 
458323(PTGIS)
PPS: 
100987973(PTGIS)
GGO: 
101132214(PTGIS)
PON: 
100440673(PTGIS)
NLE: 
100592236(PTGIS)
MCC: 
703407(PTGIS)
MCF: 
102123511(PTGIS)
CJC: 
100403062(PTGIS)
MMU: 
19223(Ptgis)
RNO: 
25527(Ptgis)
CGE: 
100757024(Ptgis)
NGI: 
103735556(Ptgis)
HGL: 
101700601(Ptgis)
OCU: 
TUP: 
102496170(PTGIS)
CFA: 
100856661(PTGIS)
AML: 
100466540(PTGIS)
UMR: 
103669841(PTGIS)
FCA: 
101082050(PTGIS)
PTG: 
102952139(PTGIS)
BTA: 
282021(PTGIS)
BOM: 
102279286(PTGIS)
PHD: 
102317373(PTGIS)
CHX: 
100860894(PTGIS)
OAS: 
101116418(PTGIS)
SSC: 
100126284(PTGIS)
CFR: 
102521764(PTGIS)
BACU: 
103018962(PTGIS)
LVE: 
103069768(PTGIS)
ECB: 
100071412(PTGIS)
MYB: 
102249227(PTGIS)
MYD: 
102772939(PTGIS)
PALE: 
102885283(PTGIS)
MDO: 
100029131(PTGIS)
SHR: 
100924178(PTGIS)
OAA: 
100076102(PTGIS)
ASN: 
102380148(PTGIS)
AMJ: 
102570396(PTGIS)
PSS: 
102459815(PTGIS)
CMY: 
102929462(PTGIS)
ACS: 
100565699(ptgis)
PBI: 
103056719(PTGIS)
XTR: 
100492372(ptgis)
DRE: 
559148(ptgis)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102358660(PTGIS)
CMK: 
103190529(ptgis)
 » show all
Taxonomy
Reference
1  [PMID:6338016]
  Authors
DeWitt DL, Smith WL.
  Title
Purification of prostacyclin synthase from bovine aorta by immunoaffinity  chromatography. Evidence that the enzyme is a hemoprotein.
  Journal
J. Biol. Chem. 258 (1983) 3285-93.
Reference
2  [PMID:7023490]
  Authors
Ullrich V, Castle L, Weber P.
  Title
Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase.
  Journal
Biochem. Pharmacol. 30 (1981) 2033-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
65802-86-0

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