| Entry |
|
|---|
| Name |
prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase |
|---|
| Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
 |
|---|
| Sysname |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoat
e 6-isomerase |
|---|
| Reaction(IUBMB) |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-
dienoate =
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-
dienoate [RN:R02267] |
|---|
| Reaction(KEGG) |
R02267
 |
|---|
| Substrate |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-
dienoate [CPD:C00427] |
|---|
| Product |
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-
dienoate [CPD:C01312] |
|---|
| Cofactor |
Heme [CPD:C00032] |
|---|
| Comment |
Converts prostaglandin H2 into prostaglandin I2 (prostacyclin). A
heme-thiolate protein. |
|---|
| Pathway |
PATH: ec00590 Arachidonic acid metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01831 cytochrome P450, family 8, subfamily A (Prostacyclin
synthase) |
|---|
| Genes |
HSA: 5740(PTGIS)
PTR: 458323(PTGIS)
MCC: 703407(PTGIS)
MMU: 19223(Ptgis)
RNO: 25527(Ptgis)
CFA: 485919(PTGIS)
BTA: 282021(PTGIS)
ECB: 100071412
MDO: 100029131
OAA: 100076102
DRE: 559148(ptgisl)
 |
|---|
| Structures |
PDB: 2IAG 3B6H 3B98 3B99 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6338016]
DeWitt DL, Smith WL.
Purification of prostacyclin synthase from bovine aorta by
immunoaffinity chromatography. Evidence that the enzyme is a
hemoprotein.
J. Biol. Chem. 258 (1983) 3285-93.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7023490]
Ullrich V, Castle L, Weber P.
Spectral evidence for the cytochrome P450 nature of prostacyclin
synthetase.
Biochem. Pharmacol. 30 (1981) 2033-6.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.3.99.4
IUBMB Enzyme Nomenclature: 5.3.99.4
ExPASy - ENZYME nomenclature database: 5.3.99.4
BRENDA, the Enzyme Database: 5.3.99.4
CAS: 65802-86-0 |
|---|
