KEGG   ENZYME: 5.3.99.5Help
Entry
EC 5.3.99.5                 Enzyme                                 

Name
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN:R02268]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD:C02198]
Comment
Converts prostaglandin H2 into thromboxane A2. A heme-thiolate protein.
History
EC 5.3.99.5 created 1984, modified 1990
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K01832  
thromboxane-A synthase
Genes
HSA: 
6916(TBXAS1)
PTR: 
463774(TBXAS1)
PPS: 
100974860(TBXAS1)
GGO: 
101143018(TBXAS1)
PON: 
100173366(TBXAS1)
MCC: 
711748(TBXAS1)
MCF: 
102128548(TBXAS1)
MMU: 
21391(Tbxas1)
RNO: 
24886(Tbxas1)
CGE: 
100772642(Tbxas1)
HGL: 
101697368(Tbxas1)
TUP: 
102482189(TBXAS1)
CFA: 
482771(TBXAS1)
AML: 
100481563(TBXAS1)
FCA: 
PTG: 
102970130(TBXAS1)
BTA: 
509326(TBXAS1)
BOM: 
102269002(TBXAS1)
PHD: 
102319354(TBXAS1)
CHX: 
102178240(TBXAS1)
OAS: 
101111361(TBXAS1)
SSC: 
397112(TBXAS1)
CFR: 
102522566(TBXAS1)
BACU: 
103014081(TBXAS1)
LVE: 
103076764(TBXAS1)
ECB: 
100066198(TBXAS1)
MYB: 
102246253(TBXAS1)
MYD: 
102752445(TBXAS1)
PALE: 
102880503(TBXAS1)
MDO: 
100023523(TBXAS1)
SHR: 
100933239(TBXAS1)
OAA: 
100087744(TBXAS1)
GGA: 
418101(TBXAS1)
MGP: 
TGU: 
100220562(TBXAS1)
FAB: 
101821781(TBXAS1)
PHI: 
102099408(TBXAS1)
APLA: 
101799380(TBXAS1)
FPG: 
101921622(TBXAS1)
FCH: 
102058879(TBXAS1)
CLV: 
102090566(TBXAS1)
ASN: 
102382949(TBXAS1)
AMJ: 
102558059(TBXAS1)
PSS: 
102461458(TBXAS1)
CMY: 
102935048(TBXAS1)
ACS: 
100561371(tbxas1)
PBI: 
XLA: 
379702 779365(tbxas1)
XTR: 
100327243(tbxas1)
DRE: 
792041(tbxas1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350410(TBXAS1)
CMK: 
103181850(tbxas1)
ISC: 
AQU: 
SITA: 
ATR: 
s00036p00136810(AMTR_s00036p00136810)
CRE: 
CSL: 
CVR: 
 » show all
Taxonomy
Reference
1  [PMID:3745158]
  Authors
Shen RF, Tai HH.
  Title
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.
  Journal
J. Biol. Chem. 261 (1986) 11592-9.
Reference
2  [PMID:6221511]
  Authors
Ullrich V, Haurand M.
  Title
Thromboxane synthase as a cytochrome P450 enzyme.
  Journal
Adv. Prostaglandin. Thromboxane. Leukot. Res. 11 (1983) 105-10.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
61276-89-9

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