KEGG   ENZYME: 5.3.99.8Help
Entry
EC 5.3.99.8                 Enzyme                                 
Name
capsanthin/capsorubin synthase;
CCS;
ketoxanthophyll synthase;
capsanthin-capsorubin synthase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
violaxanthin---capsorubin isomerase (ketone-forming)
Reaction(IUBMB)
(1) violaxanthin = capsorubin [RN:R07320];
(2) antheraxanthin = capsanthin [RN:R07321]
Reaction(KEGG)
Substrate
violaxanthin [CPD:C08614];
antheraxanthin [CPD:C08579]
Product
capsorubin [CPD:C08585];
capsanthin [CPD:C08584]
Comment
This multifunctional enzyme is induced during chromoplast differentiation in plants [1]. Isomerization of the epoxide ring of violaxanthin gives the cyclopentyl-ketone of capsorubin or capsanthin.
Pathway
Carotenoid biosynthesis
Orthology
K14593  
capsanthin/capsorubin synthase
Genes
RCU: 
POP: 
VVI: 
Taxonomy
Reference
1  [PMID:7920703]
  Authors
Bouvier F, Hugueney P, d'Harlingue A, Kuntz M, Camara B.
  Title
Xanthophyll biosynthesis in chromoplasts: isolation and molecular cloning of an enzyme catalyzing the conversion of 5,6-epoxycarotenoid into ketocarotenoid.
  Journal
Plant. J. 6 (1994) 45-54.
  Organism
Capsicum annuum
  Sequence
NCBI-GI: 522120
Reference
2  [PMID:9526511]
  Authors
Lefebvre V, Kuntz M, Camara B, Palloix A.
  Title
The capsanthin-capsorubin synthase gene: a candidate gene for the y locus controlling the red fruit colour in pepper.
  Journal
Plant. Mol. Biol. 36 (1998) 785-9.
  Organism
Capsicum annuum
Reference
3  [PMID:12549109]
  Authors
Xu CJ, Chen DM, Zhang SL.
  Title
[Molecular cloning of full length capsanthin/capsorubin synthase homologous gene from orange (Citrus sinensis)]
  Journal
Shi. Yan. Sheng. Wu. Xue. Bao. 34 (2001) 147-50.
  Organism
Citrus sinensis
  Sequence
NCBI-GI: 11131528
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
162032-85-1
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