| Entry |
|
|---|
| Name |
precorrin-8X methylmutase;
precorrin isomerase;
hydrogenobyrinic acid-binding protein |
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| Class |
Isomerases;
Intramolecular transferases;
Transferring acyl groups
 |
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| Sysname |
precorrin-8X 11,12-methylmutase |
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| Reaction(IUBMB) |
precorrin-8X = hydrogenobyrinate [RN:R05177] |
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| Reaction(KEGG) |
R05177;
(other) R05814
 |
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| Substrate |
precorrin 8X [CPD:C06408] |
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| Product |
hydrogenobyrinate [CPD:C06399] |
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| Pathway |
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K06042 precorrin-8X methylmutase |
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| Genes |
OLU: OSTLU_28645
STY: STY2238(cbiC)
STT: t0841(cbiC)
SPT: SPA0838(cbiC)
SEK: SSPA0783(cbiC)
SPQ: SPAB_01072(cbiC)
SEI: SPC_1682(cbiC)
SEC: SC2041(cbiC)
SEH: SeHA_C2255(cbiC)
SEE: SNSL254_A2209(cbiC)
SEW: SeSA_A2202(cbiC)
SEA: SeAg_B2155(cbiC)
SED: SeD_A2368(cbiC)
SET: SEN2031(cbiC)
SES: SARI_00855(cbiC)
STM: STM2033(cbiC)
YEN: YE2723(cbiC)
PLU: plu2997(cbiC)
PAY: PAU_01603(cbiC)
KPN: KPN_03198(cbiC)
KPE: KPK_0918(cbiC)
KPU: KP1_4464
CKO: CKO_00805(cbiC)
EIC: NT01EI_2191
ETR: ETAE_2002(cbiC)
VSP: VS_2662
PAE: PA2905(cobH)
PAU: PA14_26500(cobH)
PAP: PSPA7_2249(cobH)
PAG: PLES_21591(cobH)
PPU: PP_4828(cobH)
PPF: Pput_4706(cobH)
PPG: PputGB1_4884(cobH)
PPW: PputW619_4618(cobH)
PST: PSPTO_4876(cobH)
PSB: Psyr_4416(cobH)
PSP: PSPPH_4459(cobH)
PFL: PFL_0658(cobH)
PFO: Pfl01_0605(cobH)
PFS: PFLU0605(cobH)
PEN: PSEEN4870(cobH)
PMY: Pmen_4572(cobH)
SSE: Ssed_2081
MCA: MCA2298(cobH)
HHA: Hhal_1349
HCH: HCH_06473(cobH)
MMW: Mmwyl1_3376
TAU: Tola_1679
CVI: CV_1567(cbiC)
RSO: RS03744(RSp0623)
BMA: BMA1162(cobH)
BMV: BMASAVP1_A1603(cobH)
BML: BMA10229_A0265(cobH)
BMN: BMA10247_0895(cobH)
BPS: BPSL1760(cobH)
BPM: BURPS1710b_2112(cobH)
BPL: BURPS1106A_1966(cobH)
BPD: BURPS668_1949(cobH)
BPR: GBP346_A1990
BTE: BTH_I2399(cobH)
BVI: Bcep1808_1609(cobH)
BUR: Bcep18194_A4823(cobH)
BCN: Bcen_1193(cobH)
BCH: Bcen2424_1673(cobH)
BCM: Bcenmc03_1646(cobH)
BCJ: BCAL1725(cobH)
BAM: Bamb_1573(cobH)
BAC: BamMC406_1591(cobH)
BMU: Bmul_1569(cobH)
BMJ: BMULJ_01675(cobH)
BXE: Bxe_B1244(cobH)
BPH: Bphy_3144(cobH)
BPY: Bphyt_5370(cobH)
BGL: bglu_1g18440
POL: Bpro_2777
PNA: Pnap_2161
AAV: Aave_0070
DAC: Daci_5850(cobH)
VAP: Vapar_1022
CTT: CtCNB1_1877
MPT: Mpe_B0440(cobH) Mpe_B0475(cobH)
AZO: azo3531(cbiC)
DAR: Daro_1691
APP: CAP2UW1_2617
GSU: GSU2999(cobH)
GME: Gmet_0477
GUR: Gura_0033
GLO: Glov_3654
GBM: Gbem_3545
GEO: Geob_0030
GEM: GM21_3611
PCA: Pcar_0480
PPD: Ppro_1269 Ppro_1298
DVU: DVU3087(cobH)
DVL: Dvul_0292
DVM: DvMF_2253
DDE: Dde_0342
DDS: Ddes_0027
DMA: DMR_05060(cbiC)
DSA: Desal_1524
DBA: Dbac_0965
DPS: DP0219
DAL: Dalk_0445
DAT: HRM2_00180(cbiC)
SCL: sce0238(cobH)
SFU: Sfum_2136
MLO: mlr1379(cobH)
SME: SMc03192(cobH)
SMD: Smed_2817(cobH)
ATU: Atu2802(cobH)
ATC: AGR_C_5081
ARA: Arad_9595(cobH)
AVI: Avi_2639(cobH)
RET: RHE_PE00454(cobH)
REC: RHECIAT_PA0000377(cobH)
RLE: pRL110630(cobH)
RLT: Rleg2_6020(cobH)
RLG: Rleg_7175
RHI: NGR_c29800(cobH)
BME: BMEI0714(cobH)
BMF: BAB1_1305(cobH)
BMB: BruAb1_1288(cobH)
BMC: BAbS19_I12180(cobH)
BMS: BR1287(cobH)
BMT: BSUIS_A1337(cobH)
BOV: BOV_1250(cobH)
BCS: BCAN_A1310(cobH)
BMR: BMI_I1300(cobH)
OAN: Oant_1898(cobH)
BJA: blr3265(cobH)
BRA: BRADO4905(cobH)
BBT: BBta_3146(cobH)
RPA: RPA2090(cobH)
RPB: RPB_3178(cobH)
RPC: RPC_1888(cobH)
RPD: RPD_2320(cobH)
RPE: RPE_2225(cobH)
RPT: Rpal_2380(cobH)
XAU: Xaut_3284(cobH)
AZC: AZC_3937(cobH)
MEX: Mext_1437
MEA: Mex_1p1326(cobH)
MDI: METDI2098(cobH)
MRD: Mrad2831_3117
MET: M446_2440
MPO: Mpop_1434
MCH: Mchl_1712 Mchl_5691
MNO: Mnod_2151
BID: Bind_3509
MSL: Msil_3266
HCI: HCDSEM_006(cobH)
SIL: SPO2865(cobH)
SIT: TM1040_2212(cobH)
RSP: RSP_6217(cobH)
RSH: Rsph17029_1469(cobH)
RSQ: Rsph17025_1519(cobH)
RSK: RSKD131_1136
JAN: Jann_2929(cobH)
RDE: RD1_3825(cobH)
PDE: Pden_2534(cobH)
DSH: Dshi_0172(cobH)
NAR: Saro_0340(cobH)
GBE: GbCGDNIH1_0660
APT: APA01_14550(cobH)
RRU: Rru_A2991(cobH)
MAG: amb0295
MGM: Mmc1_3134
GKA: GK1802
GTN: GTNG_1691(cbiC)
GWC: GWCH70_1553
GYC: GYMC61_2613
AFL: Aflv_2177
LMO: lmo1193(cbiC)
LMF: LMOf2365_1202(cbiC)
LMH: LMHCC_1458(cbiC)
LMC: Lm4b_01197
LIN: lin1156(cbiC)
LWE: lwe1150(cbiC)
LSP: Bsph_3443
BBE: BBR47_12480(cbiC)
SSA: SSA_0465(cbiC) SSA_0466(cbiC)
LRE: Lreu_1720(cbiC)
LRF: LAR_1608(cbiC)
CAC: CAC1376(cbiC)
CPE: CPE1227(cbiC)
CPF: CPF_1435(cbiC)
CPR: CPR_1241(cbiC)
CTC: CTC00732(cbiC)
CNO: NT01CX_0582(cbiC)
CDF: CD3430(cbiC)
CDC: CD196_3206(cbiC)
CDL: CDR20291_3252(cbiC)
CBO: CBO0925(cbiC)
CBA: CLB_0966(cbiC)
CBH: CLC_0980(cbiC)
CBY: CLM_1073(cobH)
CBL: CLK_0363(cbiC)
CBK: CLL_A2937(cbiC)
CBB: CLD_3634(cbiC)
CBI: CLJ_B0977(cobH)
CBT: CLH_2683(cbiC)
CBF: CLI_1014(cbiC)
CBE: Cbei_2311(cbiC)
CKL: CKL_0723(cbiC)
CKR: CKR_0645
CPY: Cphy_1382
CCE: Ccel_1285
AMT: Amet_0069
AOE: Clos_1015
VPR: Vpar_1139
DSY: DSY4063(cobH)
DHD: Dhaf_1303
DRM: Dred_2706
DAE: Dtox_1298
PTH: PTH_0957(cobH)
DAU: Daud_1858
HMO: HM1_2394
EEL: EUBELI_20187
ERE: EUBREC_1918
TEX: Teth514_0308
CHY: CHY_0767(cobH)
MTA: Moth_1097
ADG: Adeg_0939
NTH: Nther_0927
MTU: Rv2065(cobH)
MTC: MT2125(cobH)
MRA: MRA_2079(cobH)
MTF: TBFG_12101(cobH)
MTB: TBMG_01916(TBMG_01916.1)
MBO: Mb2091(cobH)
MBB: BCG_2084(cobH)
MBT: JTY_2078(cobH)
MPA: MAP1811(cobH)
MAV: MAV_2431
MSM: MSMEG_3872(cobH)
MUL: MUL_2289(cobH)
MVA: Mvan_3430(cobH)
MGI: Mflv_3105(cobH)
MAB: MAB_2199c(cobH)
MMC: Mmcs_2488(cobH)
MKM: Mkms_2533(cobH)
MJL: Mjls_2525(cobH)
MMI: MMAR_3045(cobH)
CDI: DIP1232(cobH)
CKP: ckrop_0899(cobH)
NFA: nfa31510(cobH)
RHA: RHA1_ro00173
RER: RER_31430(cobH)
ROP: ROP_02930(cobH)
GBR: Gbro_2480
SCO: SCO3282(cobH)
SMA: SAV_6406(cobH)
SGR: SGR_3823(cobH)
PAC: PPA0429(cobH)
NCA: Noca_2893
TFU: Tfu_0317(cobH)
TCU: Tcur_1319
SRO: Sros_5593
FRA: Francci3_1520(cobH)
FRE: Franean1_2422
FAL: FRAAL2332(cobH) FRAAL3733
NML: Namu_0152
SEN: SACE_5952(cobH)
SVI: Svir_17660
AMI: Amir_1782
STP: Strop_2518
SAQ: Sare_2700
CAI: Caci_6032
RXY: Rxyl_0645
AFO: Afer_0800
SHI: Shel_21130
TDE: TDE2555(cobH)
LIL: LB161(cbiC)
LIC: LIC20131(cobH)
LBJ: LBJ_4181(cobH)
LBL: LBL_4196(cobH)
BFR: BF2518
BFS: BF2547(cobJ)
BVU: BVU_3083
PGI: PG0213
PDI: BDI_1067
FNU: FN0970
LBA: Lebu_0096
STR: Sterm_1008
TAI: Taci_0055
SYN: sll0794(merR) sll0916(cbiC) slr1467
SYW: SYNW0074(cobH)
SYC: syc2242_c(cobH)
SYF: Synpcc7942_1852(cobH)
SYD: Syncc9605_0073
SYE: Syncc9902_0073
SYG: sync_0078(cobH)
SYR: SynRCC307_0077(cobH)
SYX: SynWH7803_0083(cobH)
SYP: SYNPCC7002_A0528(cobH)
CYA: CYA_0461(cobH-1) CYA_1574(cobH-2)
CYB: CYB_0225(cobH-1) CYB_0379(cobH-2)
TEL: tll0173(cobH) tlr1064
MAR: MAE_02730(cobH)
CYT: cce_1970(cbiC2) cce_3969(cbiC1)
CYP: PCC8801_1312 PCC8801_1477
CYC: PCC7424_4511 PCC7424_5060
CYN: Cyan7425_1281 Cyan7425_1287
CYH: Cyan8802_1340 Cyan8802_1504
GVI: gvip030(cobH)
ANA: all0456 all2544 alr3162
NPU: Npun_F4020 Npun_F6482 Npun_R4919
AVA: Ava_0476 Ava_2866 Ava_3862
PMA: Pro1806(cobH)
PMM: PMM1646(cobH)
PMT: PMT0075(cobH)
PMN: PMN2A_1244
PMI: PMT9312_1738
PMB: A9601_18551(cobH)
PMC: P9515_18361(cobH)
PMF: P9303_00841(cobH)
PMG: P9301_18361(cobH)
PMH: P9215_19191(cobH)
PMJ: P9211_17721(cobH)
PME: NATL1_21141(cobH)
TER: Tery_1670(cobH) Tery_3745
AMR: AM1_3664
CTE: CT0387(cbiCH)
RRS: RoseRS_0567
RCA: Rcas_0642
CAU: Caur_2570
CAG: Cagg_1269
CHL: Chy400_2777
DGE: Dgeo_2360
DDR: Deide_2p01580(cobH)
TTH: TT_P0009
TTJ: TTHB052
TME: Tmel_0697
TAF: THA_1067
MJA: MJ0930(cbiC)
MFE: Mefer_0764
MVU: Metvu_1748
MMP: MMP0330(cbiC)
MMQ: MmarC5_1343(cbiC)
MMX: MmarC6_0621(cbiC)
MMZ: MmarC7_1332(cbiC)
MAE: Maeo_0015(cbiC)
MVN: Mevan_1341(cbiC)
MAC: MA4258(cbiC)
MBA: Mbar_A0630
MMA: MM_0994
MBU: Mbur_2355
MTP: Mthe_0143
MHU: Mhun_3214
MLA: Mlab_1081
MEM: Memar_0513
MBN: Mboo_1225
MPL: Mpal_1718
MTH: MTH227(cbiC)
MST: Msp_1179(cbiC)
MSI: Msm_1234(cbiC)
MKA: MK1196(cobH)
AFU: AF0724(cbiH)
HAL: VNG1567G(cbiC)
HSL: OE3237F(cbiC)
HMA: rrnAC3020(cbiC)
HWA: HQ2297A(cbiC)
NPH: NP1090A(cbiC)
HLA: Hlac_3460
HMU: Hmuk_1858
TAC: Ta0654
TVO: TVN0922
PTO: PTO0040 PTO0111
SSO: SSO2308(cbiC)
STO: ST1824
SAI: Saci_0399
SIS: LS215_0113
SIA: M1425_0113
SIM: M1627_0113
SID: M164_0115
SIY: YG5714_0115
SIN: YN1551_0113
MSE: Msed_2099
PAI: PAE0343
PCL: Pcal_1526
TNE: Tneu_0296
NMR: Nmar_0080
 |
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| Structures |
PDB: 1F2V 1I1H 1OU0 1V9C 2AFR 2AFV |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:1732194]
Thibaut D, Couder M, Famechon A, Debussche L, Cameron B, Crouzet J,
Blanche F.
The final step in the biosynthesis of hydrogenobyrinic acid is
catalyzed by the cobH gene product with precorrin-8x as the
substrate.
J. Bacteriol. 174 (1992) 1043-9.
Pseudomonas denitrificans |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:8501034]
Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM.
Characterization of the cobalamin (vitamin B12) biosynthetic genes
of Salmonella typhimurium.
J. Bacteriol. 175 (1993) 3303-16.
Salmonella typhimurium |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:1451790]
Roessner CA, Warren MJ, Santander PJ, Atshaves BP, Ozaki S,
Stolowich NJ, Iida K, Scott AI.
Expression of 9 Salmonella typhimurium enzymes for cobinamide
synthesis. Identification of the 11-methyl and 20-methyl
transferases of corrin biosynthesis.
FEBS. Lett. 301 (1992) 73-8.
Salmonella typhimurium |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:2211521]
Crouzet J, Cameron B, Cauchois L, Rigault S, Rouyez MC, Blanche F,
Thibaut D, Debussche L.
Genetic and sequence analysis of an 8.7-kilobase Pseudomonas
denitrificans fragment carrying eight genes involved in
transformation of precorrin-2 to cobyrinic acid.
J. Bacteriol. 172 (1990) 5980-90.
Pseudomonas denitrificans |
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| Other DBs |
ExplorEnz - The Enzyme Database: 5.4.1.2
IUBMB Enzyme Nomenclature: 5.4.1.2
ExPASy - ENZYME nomenclature database: 5.4.1.2
BRENDA, the Enzyme Database: 5.4.1.2
CAS: 138238-71-8 |
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