| Entry |
|
|---|
| Name |
bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase |
|---|
| Class |
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
 |
|---|
| Sysname |
3-phospho-D-glycerate 1,2-phosphomutase |
|---|
| Reaction(IUBMB) |
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate
[RN:R01662] |
|---|
| Reaction(KEGG) |
R01662
 |
|---|
| Substrate |
3-phospho-D-glyceroyl phosphate [CPD:C00236] |
|---|
| Product |
2,3-bisphospho-D-glycerate [CPD:C01159] |
|---|
| Comment |
In the direction shown, this enzyme is phosphorylated by
3-phosphoglyceroyl phosphate, to give phosphoenzyme and
3-phosphoglycerate. The latter is rephosphorylated by the enzyme to
yield 2,3-bisphosphoglycerate, but this reaction is slowed by
dissociation of 3-phosphoglycerate from the enzyme, which is
therefore more active in the presence of added 3-phosphoglycerate.
This enzyme also catalyses, slowly, the reactions of EC 3.1.3.13
(bisphosphoglycerate phosphatase) and EC 5.4.2.1 (phosphoglycerate
mutase). |
|---|
| Pathway |
PATH: ec00010 Glycolysis / Gluconeogenesis
PATH: ec01061 Biosynthesis of phenylpropanoids |
|---|
| Orthology |
KO: K01837 bisphosphoglycerate mutase |
|---|
| Genes |
HSA: 669(BPGM)
PTR: 463746(BPGM)
MCC: 706741(BPGM)
MMU: 12183(Bpgm)
RNO: 296973(Bpgm)
CFA: 482704(BPGM)
BTA: 533785(BPGM) 617267 784340 785763
ECB: 100065115
MDO: 100021814
OAA: 100075920
GGA: 418172(RCJMB04_32o10)
TGU: 100224087
XLA: 444102 444279
XTR: 549353
DRE: 436903(bpgm)
HMA: rrnAC2859(gpmB)
 |
|---|
| Structures |
PDB: 1T8P 1YFK 1YJX 2A9J 2F90 2H4X 2H4Z 2H52 2HHJ 2RFL |
|---|
Reference
Authors
Title
Journal
|
1
Ray, W.J., Jr. and Peck, E.J., Jr.
Phosphomutases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p.
407-477. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:5687724]
Rose ZB.
The purification and properties of diphosphoglycerate mutase from
human erythrocytes.
J. Biol. Chem. 243 (1968) 4810-20.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:6255773]
Rose ZB.
The enzymology of 2,3-bisphosphoglycerate.
Adv. Enzymol. Relat. Areas. Mol. Biol. 51 (1980) 211-53.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.4.2.4
IUBMB Enzyme Nomenclature: 5.4.2.4
ExPASy - ENZYME nomenclature database: 5.4.2.4
BRENDA, the Enzyme Database: 5.4.2.4
CAS: 37211-69-1 |
|---|
