KEGG   ENZYME: 5.4.2.4Help
Entry
EC 5.4.2.4                  Enzyme                                 

Name bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase
Class Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
BRITE hierarchy
Sysname 3-phospho-D-glycerate 1,2-phosphomutase
Reaction(IUBMB) 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate
[RN:R01662]
Reaction(KEGG) R01662
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Substrate 3-phospho-D-glyceroyl phosphate [CPD:C00236]
Product 2,3-bisphospho-D-glycerate [CPD:C01159]
Comment In the direction shown, this enzyme is phosphorylated by
3-phosphoglyceroyl phosphate, to give phosphoenzyme and
3-phosphoglycerate. The latter is rephosphorylated by the enzyme to
yield 2,3-bisphosphoglycerate, but this reaction is slowed by
dissociation of 3-phosphoglycerate from the enzyme, which is
therefore more active in the presence of added 3-phosphoglycerate.
This enzyme also catalyses, slowly, the reactions of EC 3.1.3.13
(bisphosphoglycerate phosphatase) and EC 5.4.2.1 (phosphoglycerate
mutase).
Pathway PATH: ec00010  Glycolysis / Gluconeogenesis
PATH: ec01061  Biosynthesis of phenylpropanoids
Orthology KO: K01837  bisphosphoglycerate mutase
Genes HSA: 669(BPGM)
PTR: 463746(BPGM)
MCC: 706741(BPGM)
MMU: 12183(Bpgm)
RNO: 296973(Bpgm)
CFA: 482704(BPGM)
BTA: 533785(BPGM) 617267 784340 785763
ECB: 100065115
MDO: 100021814
OAA: 100075920
GGA: 418172(RCJMB04_32o10)
TGU: 100224087
XLA: 444102 444279
XTR: 549353
DRE: 436903(bpgm)
HMA: rrnAC2859(gpmB)
Taxonomy
Structures PDB: 1T8P  1YFK  1YJX  2A9J  2F90  2H4X  2H4Z  2H52  2HHJ  2RFL  
Reference
  Authors
  Title
  Journal

1
Ray, W.J., Jr. and Peck, E.J., Jr.
Phosphomutases.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p.
407-477.
Reference
  Authors
  Title

  Journal
  Organism
2  [PMID:5687724]
Rose ZB.
The purification and properties of diphosphoglycerate mutase from
human erythrocytes.
J. Biol. Chem. 243 (1968) 4810-20.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title
  Journal
  Organism
3  [PMID:6255773]
Rose ZB.
The enzymology of 2,3-bisphosphoglycerate.
Adv. Enzymol. Relat. Areas. Mol. Biol. 51 (1980) 211-53.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 5.4.2.4
IUBMB Enzyme Nomenclature: 5.4.2.4
ExPASy - ENZYME nomenclature database: 5.4.2.4
BRENDA, the Enzyme Database: 5.4.2.4
CAS: 37211-69-1

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