| Entry |
|
|---|
| Name |
isochorismate synthase;
MenF |
|---|
| Class |
Isomerases;
Intramolecular transferases;
Transferring hydroxy groups
 |
|---|
| Sysname |
isochorismate hydroxymutase |
|---|
| Reaction(IUBMB) |
chorismate = isochorismate [RN:R01717] |
|---|
| Reaction(KEGG) |
R01717
 |
|---|
| Substrate |
chorismate [CPD:C00251] |
|---|
| Product |
isochorismate [CPD:C00885] |
|---|
| Comment |
Requires Mg2+. The reaction is reversible. |
|---|
| Pathway |
PATH: ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
PATH: ec01053 Biosynthesis of siderophore group nonribosomal
peptides
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01851 salicylate biosynthesis isochorismate synthase
KO: K02361 isochorismate synthase
KO: K02552 menaquinone-specific isochorismate synthase
KO: K04781 salicylate synthetase |
|---|
| Genes |
ATH: AT1G18870(ICS2) AT1G74710(EDS16)
POP: POPTR_569985(ICS)
RCU: RCOM_1513750
VVI: 100243400(GSVIVT00000099001)
OSA: 4346852(Os09g0361500)
SBI: SORBI_02g022920(SORBIDRAFT_02g022920)
ZMA: 100275708 100275713(si486016e08b)
PPP: PHYPADRAFT_118465
CRE: CHLREDRAFT_120595
OLU: OSTLU_37751
TPS: THAPSDRAFT_263409
ECO: b0593(entC) b2265(menF)
ECJ: JW0585(entC) JW2260(menF)
ECD: ECDH10B_0553(entC) ECDH10B_2426(menF)
EBW: BWG_0466(entC) BWG_2039(menF)
ECE: Z0735(entC) Z3525(menF)
ECS: ECs0632 ECs3153
ECF: ECH74115_0678(entC) ECH74115_3407(menF)
ETW: ECSP_0647(entC) ECSP_3143(menF)
ECG: E2348C_0495(entC) E2348C_2410(menF)
ECC: c0680(entC) c2419 c2809(menF)
ECI: UTI89_C0595(entC) UTI89_C2178(ybtS) UTI89_C2549(menF)
ECP: ECP_0625 ECP_1937 ECP_2309
ECV: APECO1_1052 APECO1_1456(entC) APECO1_4296(menF)
ECW: EcE24377A_0613(entC) EcE24377A_2562(menF)
ECX: EcHS_A0644(entC) EcHS_A2411(menF)
ECM: EcSMS35_0613(entC) EcSMS35_2420(menF)
ECY: ECSE_0660 ECSE_2525
ECL: EcolC_1383 EcolC_3051
ECK: EC55989_0585(entC) EC55989_2202(irp) EC55989_2513(menF)
ECQ: ECED1_0590(entC) ECED1_2244(irp) ECED1_2733(menF)
ECR: ECIAI1_0577(entC) ECIAI1_2343(menF)
ECT: ECIAI39_0570(entC) ECIAI39_1080(irp) ECIAI39_2413(menF)
ECZ: ECS88_0632(entC) ECS88_2032(irp) ECS88_2416(menF)
EUM: ECUMN_0687(entC) ECUMN_2268(irp) ECUMN_2608(menF)
ELF: LF82_0565(entC) LF82_1315(menF) LF82_p295
EBL: B21_00549(entC) B21_02151(menF)
EBD: ECBD_1393 ECBD_3061
EBR: ECB_00560(entC) ECB_02192(menF)
EOH: ECO103_0601(entC) ECO103_2732(menF)
EOI: ECO111_0623(entC) ECO111_3016(menF)
EOJ: ECO26_0668(entC) ECO26_3256(menF)
EFE: EFER_0903(menF) EFER_2501(entC)
STY: STY0639(entC) STY2541(menF)
STT: t0553(menF) t2273(entC)
SPT: SPA0553(menF) SPA2139(entC)
SEK: SSPA0517 SSPA1989
SPQ: SPAB_00671 SPAB_02968
SEI: SPC_0607(entC) SPC_1401(menF)
SEC: SC0626(entC) SC2310(menF)
SEH: SeHA_C0707 SeHA_C2550
SEE: SNSL254_A0648 SNSL254_A2495
SEW: SeSA_A0753 SeSA_A2538
SEA: SeAg_B0634 SeAg_B2446
SED: SeD_A0691 SeD_A2654
SEG: SG0599(entC) SG2339(menF)
SET: SEN0564(entC) SEN2292(menF)
SES: SARI_00589 SARI_02341
STM: STM0595(entC) STM2310(menF)
YPE: YPO1916(ybtS) YPO2528(menF)
YPK: y1659(menF) y2394(ybtS)
YPM: YP_1659(ybtS) YP_2339(menF)
YPA: YPA_1294 YPA_2020
YPN: YPN_2123
YPG: YpAngola_A1786(menF)
YPP: YPDSF_1209 YPDSF_1938
YPS: YPTB1601(ybtS) YPTB2561(menF)
YPI: YpsIP31758_1481(menF)
YPY: YPK_1588
YPB: YPTS_1718 YPTS_2655
YEN: YE1373(menF) YE2612(irp9)
SFL: SF2344(menF)
SFX: S2478(menF)
SFV: SFV_2336(menF)
SSN: SSON_0544(entC) SSON_2326(menF)
SBO: SBO_0454(entC) SBO_2302(menF)
SBC: SbBS512_E0495(entC) SbBS512_E2644(menF)
SDY: SDY_0524(entC) SDY_2461(menF)
ECA: ECA0477(entC) ECA1210(menF)
PCT: PC1_0462 PC1_1110
PWA: Pecwa_0560 Pecwa_3204
PLU: plu3074(menF)
PAY: PAU_00892(phbC)
ENT: Ent638_1125 Ent638_2815
ESA: ESA_00796 ESA_00948
CTU: Ctu_28970(menF) Ctu_30470(entC)
KPN: KPN_00611(entC) KPN_02663(menF)
KPE: KPK_1486(menF) KPK_3967(entC)
KPU: KP1_1557(entC) KP1_3583(ybtS) KP1_3904(menF)
CKO: CKO_00525 CKO_00916 CKO_02568
SPE: Spro_3284 Spro_3421
PMR: PMI1746(menF)
EIC: NT01EI_2651
ETR: ETAE_2359(menF)
DDA: Dd703_1044 Dd703_1490
DDC: Dd586_1085 Dd586_2817
DZE: Dd1591_1318 Dd1591_3015
HIN: HI0285(menF)
HIT: NTHI0393(menF)
HIP: CGSHiEE_01635
HIQ: CGSHiGG_04215
HDU: HD0621(menF)
HAP: HAPS_1259(menF)
HSO: HS_0618(menF)
HSM: HSM_0969
PMU: PM0053(menF)
MSU: MS1795(menF)
APL: APL_1042(menF)
APJ: APJL_1060(menF)
APA: APP7_1098
ASU: Asuc_0784
AAP: NT05HA_2366
AAT: D11S_2018
SML: Smlt2822(entC)
SMT: Smal_2276
VCH: VC0773 VC1976
VCO: VC0395_A0302(vibC) VC0395_A1562(menF)
VCM: VCM66_0731(vibC) VCM66_1900(menF)
VCJ: VCD_002391 VCD_003553
VVU: VV1_3173 VV2_0835
VVY: VV1115 VVA1300
VPA: VP0928
VHA: VIBHAR_01398 VIBHAR_01428
VSP: VS_2192
VEX: VEA_004033
VFI: VF_1672(menF)
VFM: VFMJ11_1797
VSA: VSAL_I1098(menF)
PPR: PBPRA2625 PBPRB1824
PAE: PA4231(pchA)
PAU: PA14_09210(pchA)
PAP: PSPA7_0869(pchA)
PAG: PLES_06961(pchA)
PST: PSPTO_2595(pchA)
PSP: PSPPH_2904(pchA)
PFL: PFL_3488(pchA)
PEN: PSEEN2504(pmsC)
AVN: Avin_21220(csbC)
ACI: ACIAD2776(entC)
ACB: A1S_2372 A1S_2581
ABY: ABAYE1104(basJ)
ABC: ACICU_02570(basJ)
ABN: AB57_2802
ABB: ABBFA_001070
SON: SO_4713
SFR: Sfri_3913
SAZ: Sama_0130
SBL: Sbal_0088
SBM: Shew185_4311
SBN: Sbal195_4451
SBP: Sbal223_4256
SLO: Shew_3677
SPC: Sputcn32_3873
SSE: Ssed_0130
SPL: Spea_4089
SHE: Shewmr4_3868
SHM: Shewmr7_3961
SHN: Shewana3_4071
SHW: Sputw3181_0080
SHL: Shal_0155
SWD: Swoo_0093
SWP: swp_4972
SDE: Sde_3400
PIN: Ping_0355
TTU: TERTU_2729(menF) TERTU_4059(dhbC)
HHA: Hhal_1126
HCH: HCH_06563
MMW: Mmwyl1_1621
AHA: AHA_0532(menF) AHA_2479
ASA: ASA_1838(entC) ASA_3738(menF)
TAU: Tola_0434
CVI: CV_1485(entC)
BPS: BPSS0581(pchA)
BPM: BURPS1710b_A2145(pchA)
BPL: BURPS1106A_A0781(pchA)
BPD: BURPS668_A0871(pchA)
BTE: BTH_II1833
BUR: Bcep18194_B0667
BCN: Bcen_3364
BCH: Bcen2424_5003
BCM: Bcenmc03_5284
BCJ: BCAM2235(pchA)
BAM: Bamb_1690
DAR: Daro_2823
APP: CAP2UW1_1908
BBA: Bd3485(menF)
DPS: DP0254
DAL: Dalk_1404
MXA: MXAN_3527 MXAN_3646
SCL: sce3879(mxcD) sce5042(dhbC)
HOH: Hoch_2018 Hoch_5716
SAT: SYN_02398
BME: BMEII0077
BMI: BMEA_B0018
BMF: BAB2_0015
BMB: BruAb2_0016(entC)
BMC: BAbS19_II00140
BMS: BRA0016(entC)
BMT: BSUIS_B0018
BOV: BOV_A0013(entC)
BMR: BMI_II16(entC)
PDE: Pden_2382
BSU: BSU30830(menF) BSU31990(dhbC)
BAN: BA2369(dhbC) BA5112(menF)
BAR: GBAA2369(dhbC) GBAA5112(menF)
BAA: BA_2863 BA_5530
BAT: BAS2205 BAS4751
BAH: BAMEG_2231(bacC) BAMEG_5146(menF)
BAI: BAA_2427(bacC) BAA_5124(menF)
BCE: BC2303 BC4856
BCA: BCE_2399(dhbC) BCE_5016(menF)
BCZ: BCZK2128(entC) BCZK4611(menF)
BCR: BCAH187_A2469(bacC) BCAH187_A4998(menF)
BCB: BCB4264_A2334(bacC) BCB4264_A4987(menF)
BCU: BCAH820_2387(bacC) BCAH820_4969(menF)
BCG: BCG9842_B0251(menF) BCG9842_B2991(bacC)
BCQ: BCQ_2295(dhbC) BCQ_4674(menF)
BCX: BCA_2436(bacC) BCA_4992(menF)
BCY: Bcer98_1755 Bcer98_3494
BTK: BT9727_2144(entC) BT9727_4589(menF)
BTL: BALH_2108(entC) BALH_4422(menF)
BWE: BcerKBAB4_2176 BcerKBAB4_4698
BLI: BL02409(menF) BL04021(dhbC)
BLD: BLi03223(menF) BLi03901(dhbC)
BAY: RBAM_027810(menF) RBAM_029040(dhbC)
BPU: BPUM_2719(menF)
OIH: OB0955(dhbC) OB2326(menF)
GKA: GK2876
GTN: GTNG_2774
GWC: GWCH70_2800
GYM: GYMC10_4576
GYC: GYMC61_0567
AFL: Aflv_0380(menF)
SAU: SA0895
SAV: SAV1042
SAW: SAHV_1035
SAM: MW0926
SAR: SAR1016
SAS: SAS0978
SAC: SACOL1051
SAB: SAB0909
SAA: SAUSA300_0945
SAX: USA300HOU_0990(menF)
SAO: SAOUHSC_00982
SAJ: SaurJH9_1101
SAH: SaurJH1_1124
SAE: NWMN_0912
SAD: SAAV_1006
SEP: SE0743
SER: SERP0629
SHA: SH1920
SSP: SSP1749
SCA: Sca_0651(menF)
LMO: lmo1676(menF)
LMF: LMOf2365_1700
LMH: LMHCC_0890
LMC: Lm4b_01689(menF)
LIN: lin1784
LWE: lwe1694
LSP: Bsph_4278 Bsph_4279
ESI: Exig_0628
EAT: EAT1b_2375
MCL: MCCL_1508
AAC: Aaci_1919
LLA: L0168(menF)
LLK: LLKF_0752(menF)
LLC: LACR_0774
LLM: llmg_1828(menF)
EFA: EF0447
LME: LEUM_0751
LCI: LCK_00953
VPR: Vpar_0373
DSY: DSY0517(menF) DSY2818
DHD: Dhaf_0469 Dhaf_3962
MTU: Rv2386c(mbtI) Rv3215(entC)
MTC: MT2454 MT3311
MRA: MRA_2409(mbtI) MRA_3254(entC)
MTF: TBFG_12411 TBFG_13241
MTB: TBMG_01589(TBMG_01589.1) TBMG_03260(TBMG_03260.1)
MBO: Mb2407c(mbtI) Mb3241(entC)
MBB: BCG_2400c(mbtI) BCG_3242(entC_1) BCG_3335(entC_2)
MBT: JTY_2394(mbtI) JTY_3237(entC_1)
MLE: ML0808(entC)
MPA: MAP2205c(trpE2) MAP3316(entC)
MAV: MAV_1792 MAV_4163
MSM: MSMEG_1925 MSMEG_4524
MUL: MUL_2537(entC) MUL_3648(mbtI)
MVA: Mvan_1787
MGI: Mflv_4680
MAB: MAB_2245 MAB_3535
MMC: Mmcs_1387
MKM: Mkms_1405
MJL: Mjls_1421
MMI: MMAR_1342(entC) MMAR_3706(mbtI)
CGL: NCgl1243(cgl1292)
CGB: cg1462(entC)
CGT: cgR_1370
CEF: CE1388
CDI: DIP1114
CJK: jk1285(menF)
CUR: cur_0768
CAR: cauri_1140(menF)
CKP: ckrop_1228(menF)
NFA: nfa54680 nfa6190
RHA: RHA1_ro04795(dhbC) RHA1_ro05194
RER: RER_11150 RER_26950
ROP: ROP_23300 ROP_48860 ROP_52440
GBR: Gbro_0621 Gbro_4032
SCO: SCO7691(SC4C2.26)
SGR: SGR_6733
TWH: TWT052(menF)
TWS: TW062
LXX: Lxx01810(menF)
CMI: CMM_2810(menF)
CMS: CMS_3013(menF)
ART: Arth_3133
AAU: AAur_3103
ACH: Achl_2828
RSA: RSal33209_2639
KRH: KRH_05420
MLU: Mlut_21330
BCV: Bcav_3233
BFA: Bfae_24140
JDE: Jden_0536
KSE: Ksed_21430
XCE: Xcel_0466
PAC: PPA0904 PPA1940
NCA: Noca_0516
TFU: Tfu_1413 Tfu_1872
TCU: Tcur_0369 Tcur_2398
SRO: Sros_4053
NML: Namu_0970
KRA: Krad_3982
SEN: SACE_3854(dhbC) SACE_6911(menF)
SVI: Svir_20870 Svir_33230
AMI: Amir_6694
RXY: Rxyl_2897
AFO: Afer_0843
CCU: Ccur_14050
ELE: Elen_2977
PCU: pc1069(menF)
BTH: BT_4700
BFR: BF1315
BFS: BF1300
BVU: BVU_2419
PGI: PG1525
PDI: BDI_1135
SRU: SRU_1350
RMR: Rmar_0581
CHU: CHU_1758(entC)
DFE: Dfer_5138
GFO: GFO_2076
FJO: Fjoh_4718
FPS: FP0658(menF)
FBA: FIC_01758
COC: Coch_1774
RBI: RB2501_15744
BBL: BLBBGE_192(entC)
BPI: BPLAN_443(entC)
OTE: Oter_3649
AMU: Amuc_1871
GAU: GAU_3222
SYN: slr0817(entC)
SYW: SYNW2308(menF)
SYC: syc1908_d(menF)
SYF: Synpcc7942_2188
SYD: Syncc9605_2439
SYE: Syncc9902_2120
SYG: sync_2656
SYR: SynRCC307_2252(menF)
SYX: SynWH7803_2319(menF)
SYP: SYNPCC7002_A0999(menF)
CYA: CYA_2455
CYB: CYB_2299
TEL: tll1213
MAR: MAE_01970(menF)
CYT: cce_4480(menF)
CYP: PCC8801_1520
CYC: PCC7424_4752
CYN: Cyan7425_5120
CYH: Cyan8802_1547
ANA: all0032
NPU: Npun_F6461
AVA: Ava_2632
PMA: Pro0202(menF)
PMM: PMM0177(menF)
PMT: PMT2060(menF)
PMN: PMN2A_1545
PMI: PMT9312_0179
PMB: A9601_01951(menF)
PMC: P9515_02061(menF)
PMF: P9303_27351(menF)
PMG: P9301_01971(menF)
PMH: P9215_01951(menF)
PMJ: P9211_01951
PME: NATL1_02521(menF)
TER: Tery_4072
AMR: AM1_1109 AM1_A0125(menF) AM1_A0247
CTE: CT1838(menF)
CPC: Cpar_0365
CCH: Cag_1701
CPH: Cpha266_2088
CPB: Cphamn1_2074
CLI: Clim_2047
PVI: Cvib_0398
PLT: Plut_0332
PPH: Ppha_2422
PAA: Paes_1877
CTS: Ctha_1990
RRS: RoseRS_0026
RCA: Rcas_4216
CAU: Caur_3654
CAG: Cagg_0219
CHL: Chy400_3941
HAU: Haur_1802
TTR: Tter_1234
HAL: VNG1083G(menF)
HSL: OE2566R(menF)
HMA: rrnAC0837(menF)
HWA: HQ1872A(menF)
NPH: NP2724A(menF)
HLA: Hlac_1487
HUT: Huta_0814
HMU: Hmuk_0041
 |
|---|
| Structures |
PDB: 2EUA 3BZM 3BZN 3GSE |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4306838]
Young IG, Gibson F.
Regulation of the enzymes involved in the biosynthesis of
2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia
coli.
Biochim. Biophys. Acta. 177 (1969) 401-11.
Escherichia coli [GN:eco], Klebsiella pneumoniae [GN:kpn] |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
2 [PMID:9952467]
van Tegelen LJ, Moreno PR, Croes AF, Verpoorte R, Wullems GJ.
Purification and cDNA cloning of isochorismate synthase from
elicited cell cultures of Catharanthus roseus.
Plant. Physiol. 119 (1999) 705-12.
Catharanthus roseus
NCBI-GI: 4127688 |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9795253]
Dahm C, Muller R, Schulte G, Schmidt K, Leistner E.
The role of isochorismate hydroxymutase genes entC and menF in
enterobactin and menaquinone biosynthesis in Escherichia coli.
Biochim. Biophys. Acta. 1425 (1998) 377-86.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:8764478]
Daruwala R, Kwon O, Meganathan R, Hudspeth ME.
A new isochorismate synthase specifically involved in menaquinone
(vitamin K2) biosynthesis encoded by the menF gene.
FEMS. Microbiol. Lett. 140 (1996) 159-63.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.4.4.2
IUBMB Enzyme Nomenclature: 5.4.4.2
ExPASy - ENZYME nomenclature database: 5.4.4.2
BRENDA, the Enzyme Database: 5.4.4.2
CAS: 37318-53-9 |
|---|
