KEGG   ENZYME: 5.4.99.2Help
Entry
EC 5.4.99.2                 Enzyme                                 
Name methylmalonyl-CoA mutase;
methylmalonyl-CoA CoA-carbonyl mutase;
methylmalonyl coenzyme A mutase;
methylmalonyl coenzyme A carbonylmutase;
(S)-methylmalonyl-CoA mutase;
(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase [incorrect]
Class Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname (R)-methylmalonyl-CoA CoA-carbonylmutase
Reaction(IUBMB) (R)-methylmalonyl-CoA = succinyl-CoA [RN:R00833]
Reaction(KEGG) R00833
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Substrate (R)-methylmalonyl-CoA [CPD:C01213]
Product succinyl-CoA [CPD:C00091]
Cofactor Cobamide [CPD:C00210]
Comment Requires a cobamide coenzyme.
Pathway PATH: ec00280  Valine, leucine and isoleucine degradation
PATH: ec00640  Propanoate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01847  methylmalonyl-CoA mutase
KO: K01848  methylmalonyl-CoA mutase, N-terminal domain
KO: K01849  methylmalonyl-CoA mutase, C-terminal domain
KO: K11942  methylmalonyl-CoA mutase
Genes HSA: 4594(MUT)
PTR: 463198(MUT)
MCC: 706189(MUT)
MMU: 17850(Mut)
RNO: 301276(RGD1564912_predicted) 688517(Mut)
CFA: 474930(MUT)
BTA: 280871(MUT)
SSC: 399535(MUT)
ECB: 100055925
MDO: 100012986
OAA: 100079946
GGA: 422049(MUT)
TGU: 100230317
DRE: 569581(mut)
BFO: BRAFLDRAFT_245763
CIN: 100184488
SPU: 576452
ISC: IscW_ISCW020522
CEL: ZK1058.1(mmcm-1)
NVE: NEMVE_v1g238314
HMG: 100209405
MBR: MONBRDRAFT_34490
DDI: DDBDRAFT_0187533
LMA: LmjF27.0300
LIF: LinJ27.0150
LBZ: LbrM27_V2.0310
PTI: PHATRDRAFT_51830
TPS: THAPSDRAFT_33685(MCM1)
ECO: b2917(scpA)
ECJ: JW2884(yliK)
EBW: BWG_2640(scpA)
ECE: Z4254(sbm)
ECS: ECs3787
ECF: ECH74115_4213(scpA)
ETW: ECSP_3883(sbm)
ECC: c3498
ECI: UTI89_C3303
ECP: ECP_2909
ECV: APECO1_3613
ECW: EcE24377A_3244(msm)
ECX: EcHS_A3075(msm)
ECM: EcSMS35_3053(msm)
ECY: ECSE_3179
ECL: EcolC_0793
ECR: ECIAI1_3037(yliK)
ECT: ECIAI39_3331(yliK)
EUM: ECUMN_3261(yliK)
ELF: LF82_p453
EBL: B21_02711(sbm)
EBD: ECBD_0821
EBR: ECB_02748(sbm)
EOH: ECO103_3491(yliK)
EOI: ECO111_3653(yliK)
EOJ: ECO26_4004(yliK)
SES: SARI_04585
YEN: YE1895
SFL: SF2902(sbm)
SFX: S3102(sbm)
SFV: SFV_2963(sbm)
SSN: SSON_3068(sbm)
NOC: Noc_1893
RSO: RSc0237
RPI: Rpic_0089
RPF: Rpic12D_0095
REU: Reut_A0253
REH: H16_A0280(sbm1) H16_A1949(sbm2) H16_B1841 H16_B1842
RME: Rmet_0210
CTI: RALTA_A0218
BVI: Bcep1808_6060
BXE: Bxe_A4277
BPH: Bphy_0156 Bphy_4569
BPY: Bphyt_0431
BGL: bglu_2p0650
PNU: Pnuc_0910
PNE: Pnec_0932
RFR: Rfer_2805 Rfer_3612
POL: Bpro_2161 Bpro_4054
PNA: Pnap_2383 Pnap_3524
AAV: Aave_2510
AJS: Ajs_2040
VEI: Veis_3398
DAC: Daci_3753
DIA: Dtpsy_1849
VAP: Vapar_2127
CTT: CtCNB1_2326
MPT: Mpe_A0903 Mpe_A1014 Mpe_B0538 Mpe_B0541
LCH: Lcho_2697 Lcho_3844
EBA: ebA2060(sbmA) ebA3738(sbmB) ebA3766 ebD52(sbmB)
AZO: azo0685(mutB) azo0696
DAR: Daro_0243 Daro_4006
APP: CAP2UW1_0492 CAP2UW1_1139 CAP2UW1_2499
GSU: GSU1578 GSU3302
GME: Gmet_1574 Gmet_1722 Gmet_3251
GUR: Gura_0654 Gura_1342 Gura_2026 Gura_3481 Gura_3482
GLO: Glov_3260
GBM: Gbem_2691 Gbem_2838
GEO: Geob_0840 Geob_3142
GEM: GM21_0572 GM21_1375 GM21_1548
PPD: Ppro_0388 Ppro_0523 Ppro_1284 Ppro_1285
BBA: Bd1853
DOL: Dole_0079 Dole_2188
DAL: Dalk_0220 Dalk_0221 Dalk_1724 Dalk_2754
DAT: HRM2_10030(mcmL) HRM2_32470(sbm)
ADE: Adeh_0259 Adeh_1832 Adeh_1834
ACP: A2cp1_0281 A2cp1_2096 A2cp1_2098
AFW: Anae109_0281 Anae109_1988 Anae109_1989 Anae109_3169
ANK: AnaeK_0270 AnaeK_2026 AnaeK_2028
MXA: MXAN_2261 MXAN_2263(mutB) MXAN_2264(mutA)
SCL: sce1655 sce2716(mcm) sce7549
HOH: Hoch_3688 Hoch_3774 Hoch_5723
SFU: Sfum_0457 Sfum_0458
MLO: mll7619 mll7621
MES: Meso_0856 Meso_0857
PLA: Plav_1625 Plav_1702
SME: SM_b20757(bhbA)
SMD: Smed_4237 Smed_5086 Smed_5088
ATU: Atu3580(mutA)
ATC: AGR_L_2498
ARA: Arad_1385(bhbA) Arad_1386(bhbA)
AVI: Avi_5687(mutA)
RET: RHE_PB00157(bhbA)
REC: RHECIAT_PC0000163(bhbA)
RLE: pRL90299
RLT: Rleg2_6136 Rleg2_6511
RLG: Rleg_6098
RHI: NGR_b20920(bhbA)
BME: BMEI0799
BMF: BAB1_1212(bhbA)
BMB: BruAb1_1195(bhbA)
BMC: BAbS19_I11280
BMS: BR1190(bhbA)
BMT: BSUIS_A1238
BCS: BCAN_A1212
BMR: BMI_I1201(bhbA)
OAN: Oant_2001
BJA: bll3054(mutA) bll3056(mutA)
BRA: BRADO2679(mutB) BRADO2682(mutA)
BBT: BBta_3021(mutB) BBta_3023(mutA)
RPA: RPA1835(mutB) RPA1837
RPB: RPB_3536 RPB_3538
RPC: RPC_1760 RPC_1762
RPD: RPD_1927 RPD_1929
RPE: RPE_1852 RPE_1854 RPE_3223 RPE_3224
RPT: Rpal_2039 Rpal_2041
NWI: Nwi_2236 Nwi_2238
NHA: Nham_2636 Nham_2638
XAU: Xaut_1197 Xaut_4729 Xaut_4731 Xaut_5018 Xaut_5021 Xaut_5043
AZC: AZC_0992 AZC_1772 AZC_1773
MEX: Mext_0290 Mext_2388 Mext_4794
MEA: Mex_1p0180(ecm) Mex_1p2390(mcmB) Mex_1p5251(mcmA)
MDI: METDI0163(ecm) METDI3170(mcmB) METDI5851(mcmA)
MRD: Mrad2831_1106 Mrad2831_1736 Mrad2831_3135
MET: M446_0036 M446_0217 M446_3042
MPO: Mpop_0366 Mpop_2345 Mpop_5337
MCH: Mchl_0334 Mchl_2665 Mchl_5261
MNO: Mnod_0038 Mnod_4573 Mnod_5425
BID: Bind_2199 Bind_2200
MSL: Msil_3784 Msil_3785
CCR: CC_2373 CC_2374 CC_3081
CCS: CCNA_02458 CCNA_02459 CCNA_03177
CAK: Caul_0836 Caul_3629 Caul_3630
PZU: PHZ_c1095(mutB) PHZ_c1096(mutA)
SIL: SPO0368 SPO1105
SIT: TM1040_1865 TM1040_3106
RSP: RSP_0961(meaA) RSP_2192(mcmA)
RSH: Rsph17029_0867 Rsph17029_2621 Rsph17029_3654 Rsph17029_3657
RSQ: Rsph17025_2300 Rsph17025_3008
RSK: RSKD131_0507 RSKD131_2353 RSKD131_3113 RSKD131_3116
JAN: Jann_0797 Jann_3367
RDE: RD1_1635(mutB) RD1_2035(mutA)
PDE: Pden_3681 Pden_3875
DSH: Dshi_0726(bhbA) Dshi_2855(mutB)
MMR: Mmar10_1119 Mmar10_1120
HNE: HNE_1326(mutB) HNE_1327(mutA) HNE_3115
HBA: Hbal_0291 Hbal_1490 Hbal_1746 Hbal_1747
NAR: Saro_0811
SAL: Sala_1221
SWI: Swit_2891
ELI: ELI_04910
RRU: Rru_A2479 Rru_A2480 Rru_A3062
RCE: RC1_3119(bhbA)
MAG: amb0310 amb4239 amb4240
MGM: Mmc1_0388
BHA: BH2955(mutA) BH2956(mutB) BH3796
GKA: GK2370 GK2371 GK3391
GTN: GTNG_2299 GTNG_2300 GTNG_3336
GWC: GWCH70_2294 GWCH70_2295 GWCH70_3339
GYC: GYMC61_0278 GYMC61_0279 GYMC61_3448
AFL: Aflv_0965 Aflv_0966 Aflv_2734
LSP: Bsph_0976 Bsph_3490 Bsph_3491
BBE: BBR47_26870 BBR47_26880 BBR47_54940
PJD: Pjdr2_2590
AMT: Amet_4541 Amet_4542
AOE: Clos_0436 Clos_0437
STH: STH1186 STH1187 STH2465 STH2466
VPR: Vpar_1247 Vpar_1248 Vpar_1762 Vpar_1763
DSY: DSY1563 DSY1564
DHD: Dhaf_2691 Dhaf_2692
DRM: Dred_1768 Dred_1769
DAE: Dtox_1909 Dtox_1910
PTH: PTH_1361(mmcE) PTH_1362(mmcF)
HMO: HM1_0376 HM1_0377 HM1_0899(mutB)
TTE: TTE1217(sbm) TTE1218(sbm2) TTE2389(sbm5)
TEX: Teth514_1854 Teth514_1855
TPD: Teth39_0902 Teth39_0903
CPO: COPRO5265_0913 COPRO5265_0914(sbm)
NTH: Nther_1486 Nther_1487
MTU: Rv1492(mutA) Rv1493(mutB)
MTC: MT1539(mutA) MT1540(mutB)
MRA: MRA_1502(mutA) MRA_1503(mutB)
MTF: TBFG_11522 TBFG_11523
MTB: TBMG_02487(TBMG_02487.1) TBMG_02488(TBMG_02488.1)
MBO: Mb1529(mutA) Mb1530(mutB)
MBB: BCG_1555(mutA) BCG_1556(mutB)
MBT: JTY_1530(mutA) JTY_1531(mutB)
MLE: ML1799(mutB) ML1800(mutA)
MLB: MLBr_01799(mutB) MLBr_01800(mutA)
MPA: MAP0673 MAP0674(mcmA2) MAP1225(mutA) MAP1226(mutB)
MAV: MAV_0856 MAV_0857 MAV_3277 MAV_3278(mutA)
MSM: MSMEG_3158(mutA) MSMEG_3159 MSMEG_4880 MSMEG_4881
MUL: MUL_0366(mcmA2b) MUL_0367(mcmA2a) MUL_1505(mutA) MUL_1506(mutB)
MVA: Mvan_2762 Mvan_2763 Mvan_4260 Mvan_4261
MGI: Mflv_2387 Mflv_2388 Mflv_3649 Mflv_3650
MAB: MAB_2711c MAB_2712c
MMC: Mmcs_3122 Mmcs_3123 Mmcs_3825 Mmcs_3826
MKM: Mkms_3183 Mkms_3184 Mkms_3899 Mkms_3900
MJL: Mjls_3133 Mjls_3134 Mjls_3811 Mjls_3812
MMI: MMAR_2302(mutA) MMAR_2303(mutB) MMAR_4797(mcmA2b)
     MMAR_4798(mcmA2a)
CGL: NCgl1471(cgl1529) NCgl1472(cgl1530)
CGB: cg1725(mcmB) cg1726(mcmA)
CGT: cgR_1587 cgR_1588
CEF: CE1650 CE1651
CDI: DIP1272(sbm) DIP1273
CKP: ckrop_0928(mcmB) ckrop_0929(mcmA)
NFA: nfa10360 nfa34660 nfa34670
RHA: RHA1_ro07233(mutA) RHA1_ro07234(mutB)
RER: RER_30880(mutA) RER_30890(mutB)
ROP: ROP_70170(mutA) ROP_70180(mutB)
GBR: Gbro_2419 Gbro_2420
SCO: SCO4800(icmB) SCO4869(mutA2) SCO5415(icmA) SCO6472(SC9C7.08c)
     SCO6832(mutA) SCO6833(SC3D9.01)
SMA: SAV_1912(meaA1) SAV_2039(mcmB) SAV_2040(meaA2) SAV_2832(icmA)
     SAV_3382(mcmA2) SAV_3460(icmB)
SGR: SGR_1171 SGR_2120 SGR_2730 SGR_6745 SGR_6746
KSE: Ksed_22170 Ksed_22180
PAC: PPA0595 PPA0596
NCA: Noca_0798 Noca_1772 Noca_1802 Noca_2131 Noca_3544 Noca_3545
     Noca_3591 Noca_4143
TFU: Tfu_2761 Tfu_2762 Tfu_2811
TCU: Tcur_1029 Tcur_2505 Tcur_2506
SRO: Sros_1242 Sros_1703 Sros_3187 Sros_3188 Sros_3556
FRA: Francci3_2169 Francci3_3005 Francci3_3006 Francci3_3652
FRE: Franean1_1034 Franean1_1077 Franean1_1943 Franean1_1944
     Franean1_4309 Franean1_4310
FAL: FRAAL4950(mutB) FRAAL4951(mutA) FRAAL5865(mcm) FRAAL5921(meaA)
ACE: Acel_0377 Acel_0674
NML: Namu_1263 Namu_3099 Namu_5166 Namu_5167
SEN: SACE_5638(mutA) SACE_5639(mutB)
SVI: Svir_05670 Svir_05680 Svir_24570
AMI: Amir_2277 Amir_6418 Amir_6419
STP: Strop_0832 Strop_3608 Strop_3621 Strop_3814
SAQ: Sare_0776 Sare_3989 Sare_4003 Sare_4204
CAI: Caci_0774 Caci_1226 Caci_1274 Caci_7994
RXY: Rxyl_1283 Rxyl_2369 Rxyl_2481
AFO: Afer_0223 Afer_0318 Afer_0726 Afer_1791
LIL: LA2956(mcm1) LB074(mcm2) LB273(mcm2) LB274(mcm3)
LIC: LIC11105(mcm1) LIC20058(mcm2) LIC20208 LIC20209(mcmA)
LBJ: LBJ_2060 LBJ_4062(meaA) LBJ_4126 LBJ_4127(sbm)
LBL: LBL_4062(meaA) LBL_4142 LBL_4143(sbm)
LBI: LEPBI_I3196 LEPBI_II0044(mcm2) LEPBI_II0094(mutB)
     LEPBI_II0095(mutA)
LBF: LBF_3084 LBF_4043(meaA) LBF_4091 LBF_4092(sbm)
ABA: Acid345_1023 Acid345_1432 Acid345_1454
ACA: ACP_0323(bhbA1) ACP_1898(bhbA2) ACP_2837
SUS: Acid_6471 Acid_6472 Acid_6955 Acid_6956 Acid_7412
BTH: BT_2090 BT_2091
BFR: BF3800 BF3801
BFS: BF3592(mutB) BF3593(mutA)
BVU: BVU_0309 BVU_0310
PGI: PG1656(mutA) PG1657(mutB)
PGN: PGN_0456 PGN_0457
PDI: BDI_2302 BDI_2303
APS: CFPG_557 CFPG_558
SRU: SRU_1689 SRU_1791 SRU_1792(mutA)
RMR: Rmar_0923
CPI: Cpin_0241 Cpin_1068 Cpin_6260
PHE: Phep_1164 Phep_3607 Phep_4240
GFO: GFO_0483 GFO_0809(mutB) GFO_0810(mutA)
FJO: Fjoh_0013 Fjoh_0014 Fjoh_2332
FPS: FP1121(mutA) FP1123(mutB) FP1940
FBA: FIC_00055 FIC_00955 FIC_02231
COC: Coch_1803
RBI: RB2501_01600 RB2501_01605 RB2501_11102
OTE: Oter_3304 Oter_3305
AMU: Amuc_1983 Amuc_1984
GAU: GAU_1457 GAU_1708 GAU_2108
TAI: Taci_0288 Taci_0289
CTE: CT0799
CPC: Cpar_0827 Cpar_0828
CCH: Cag_1222 Cag_1223
CPH: Cpha266_1164 Cpha266_1165
CPB: Cphamn1_1173
CLI: Clim_0868 Clim_0869
PVI: Cvib_1038 Cvib_1039
PLT: Plut_1291 Plut_1292
PPH: Ppha_1167 Ppha_1168
PAA: Paes_0875
CTS: Ctha_0849 Ctha_0850
RRS: RoseRS_0214 RoseRS_0544 RoseRS_0545 RoseRS_2024
RCA: Rcas_2998 Rcas_3871 Rcas_3872 Rcas_4326
CAU: Caur_0042 Caur_1844 Caur_2508 Caur_2509
CAG: Cagg_0587 Cagg_1348 Cagg_1349 Cagg_2545
CHL: Chy400_0048 Chy400_1995 Chy400_2705 Chy400_2706
HAU: Haur_3380 Haur_3987 Haur_4552
TRO: trd_0804 trd_1560
STI: Sthe_1205 Sthe_1206 Sthe_2008
DRA: DR_1084 DR_1189 DR_2032
DGE: Dgeo_0862 Dgeo_1320 Dgeo_1541
DDR: Deide_08100 Deide_11350 Deide_15650
TTH: TTC0676 TTC0677 TTC0882
TTJ: TTHA1038 TTHA1039 TTHA1246
TLE: Tlet_0705 Tlet_0706
TME: Tmel_0582 Tmel_1860
TAF: THA_1415 THA_155
FNO: Fnod_1322 Fnod_1752
PMO: Pmob_0549 Pmob_0550
KOL: Kole_1371 Kole_1372
TTR: Tter_1622 Tter_1672 Tter_1673
AFU: AF1288a AF1288b AF2215(mcmA1) AF2219(mcmA2)
HAL: VNG0481G(mcmA1) VNG0653G(mcmA1) VNG0673G(mcmA2)
HSL: OE1721R(mcmA2) OE1972F(mcmA1) OE2005F(mcmB)
HMA: rrnAC0637(mcmA1) rrnAC0934(mcmA3) rrnAC1275(mcmA2)
HWA: HQ2301A(mcmB) HQ2400A(mcmA)
NPH: NP1226A(mcmA_2) NP2320A(mcmA_1) NP2710A(mcmB)
HLA: Hlac_0510 Hlac_1016 Hlac_1182
HMU: Hmuk_2165 Hmuk_2805 Hmuk_2889
TAC: Ta0462 Ta0463
TVO: TVN0772 TVN0773
PTO: PTO0269 PTO0270
PHO: PH0275 PH1306
PAB: PAB1800(mcmA1) PAB2187(mcmA2)
PFU: PF1477 PF1946
TKO: TK0328 TK1149
TON: TON_1076 TON_1110
TGA: TGAM_1685(mutA) TGAM_1931(mutB)
TSI: TSIB_0812 TSIB_1402
APE: APE_1686.1 APE_1687
SSO: SSO2266(mcmA2) SSO2425(mcmA1)
STO: ST0552 ST2096
SAI: Saci_0062 Saci_0924
SIS: LS215_0076 LS215_0246
SIA: M1425_0076 M1425_0215
SIM: M1627_0076 M1627_0215
SID: M164_0076 M164_0234
SIY: YG5714_0078 YG5714_0219
SIN: YN1551_0076 YN1551_2822
MSE: Msed_0638 Msed_2055
NMR: Nmar_0954 Nmar_0958
Taxonomy
Structures PDB: 1E1C  1REQ  2REQ  2YXB  3BIC  3REQ  4REQ  5REQ  6REQ  7REQ  
Reference
  Authors
  Title
  Journal

 1
Barker, H.A.
Coenzyme B12-dependent mutases causing carbon chain rearrangements.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, Academic Press,
New York, 1972, p. 509-537.
Other DBs ExplorEnz - The Enzyme Database: 5.4.99.2
IUBMB Enzyme Nomenclature: 5.4.99.2
ExPASy - ENZYME nomenclature database: 5.4.99.2
UM-BBD (Biocatalysis/Biodegradation Database): 5.4.99.2
BRENDA, the Enzyme Database: 5.4.99.2
CAS: 9023-90-9
DBGET integrated database retrieval system